Search Results - "Iordanov, Mihail S."

ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells by Sauter, Kristin A.D., Magun, Eli A., Iordanov, Mihail S., Magun, Bruce E.

“…Doxorubicin is an anthracycline drug that is one of the most effective and widely used anticancer agents for the treatment of both hematologic and solid…”
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The UV (Ribotoxic) Stress Response of Human Keratinocytes Involves the Unexpected Uncoupling of the Ras-Extracellular Signal-Regulated Kinase Signaling Cascade from the Activated Epidermal Growth Factor Receptor by Iordanov, Mihail S, Choi, Remy J, Ryabinina, Olga P, Dinh, Thanh-Hoai, Bright, Robert K, Magun, Bruce E

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Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death by Vogel, Arndt, van den Berg, Inge E.T., Al‐Dhalimy, Muhsen, Groopman, John, Ou, Ching‐Nan, Ryabinina, Olga, Iordanov, Mihail S., Finegold, Milton, Grompe, Markus

“…The murine model of hereditary tyrosinemia type 1 (HT1) was used to analyze the relationship between chronic liver disease and programmed cell death in vivo…”
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Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages by Korcheva, Veselina, Wong, John, Lindauer, Meghan, Jacoby, David B., Iordanov, Mihail S., Magun, Bruce

“…Because of its lethal effects, ease of preparation, and ability to be delivered by aerosolization, ricin has been developed as a lethal weapon by various…”
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Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis. Recruitment of the epidermal growth factor receptor and activation of MAP kinases by Farley, Sherry M, Purdy, David E, Ryabinina, Olga P, Schneider, Pascal, Magun, Bruce E, Iordanov, Mihail S

“…Fas ligand (FasL) exerts potent proapoptotic and proinflammatory actions on epidermal keratinocytes and has been implicated in the pathogenesis of eczema,…”
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Fas Ligand Elicits a Caspase-Independent Proinflammatory Response in Human Keratinocytes: Implications for Dermatitis by Farley, Sherry M., Dotson, Anjali D., Purdy, David E., Sundholm, Aaron J., Schneider, Pascal, Magun, Bruce E., Iordanov, Mihail S.

“…Fas ligand (FasL) causes apoptosis of epidermal keratinocytes and triggers the appearance of spongiosis in eczematous dermatitis. We demonstrate here that FasL…”
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Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways by Iordanov, Mihail S., Paranjape, Jayashree M., Zhou, Aimin, Wong, John, Williams, Bryan R. G., Meurs, Eliane F., Silverman, Robert H., Magun, Bruce E.

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An epidermotypic model of interface dermatitis reveals individual functions of fas ligand and gamma interferon in hypergranulosis, cytoid body formation, and gene expression by Farley, Sherry M, Wood, Lisa J, Iordanov, Mihail S

“…Analysis of complex cutaneous reactions using animal models allows for the identification of essential or modulatory participants, that is, cyto- and…”
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Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis by Iordanov, M S, Ryabinina, O P, Wong, J, Dinh, T H, Newton, D L, Rybak, S M, Magun, B E

“…Cytotoxic endoribonucleases (RNases) possess a potential for use in cancer therapy. However, the molecular determinants of RNase-induced cell death are not…”
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Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs by Iordanov, Mihail S., Wong, John, Bell, John C., Magun, Bruce E.

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Different Mechanisms of c-Jun NH2-terminal Kinase-1 (JNK1) Activation by Ultraviolet-B Radiation and by Oxidative Stressors by Iordanov, Mihail S., Magun, Bruce E.

“…Irradiation of mammalian cells with ultraviolet-B radiation (UV-B) triggers the activation of a group of stress-activated protein kinases known as c-Jun…”
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Ultraviolet Radiation Triggers the Ribotoxic Stress Response in Mammalian Cells by Iordanov, M S, Pribnow, D, Magun, J L, Dinh, T H, Pearson, J A, Magun, B E

“…The ribotoxic stress response, which is conserved between prokaryotes and eukaryotes, is a cellular reaction to cytotoxic interference with the function of the…”
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Differential Requirement for the Stress-Activated Protein Kinase/c-Jun NH2-Terminal Kinase in RNA Damage-Induced Apoptosis in Primary and in Immortalized Fibroblasts by Iordanov, Mihail S, Wong, John, Newton, Dianne L, Rybak, Susanna M, Bright, Robert K, Flavell, Richard A, Davis, Roger J, Magun, Bruce E

“…Onconase, an anticancer ribonuclease, damages cellular tRNA and causes caspase-dependent apoptosis in targeted cells (M. S. Iordanov, O. P. Ryabinina, J. Wong,…”
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D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells by Ryabinina, Olga P, Subbian, Ezhilkani, Iordanov, Mihail S

“…The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their…”
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Fas Ligand-induced Proinflammatory Transcriptional Responses in Reconstructed Human Epidermis by Farley, Sherry M., Purdy, David E., Ryabinina, Olga P., Schneider, Pascal, Magun, Bruce E., Iordanov, Mihail S.

“…Fas ligand (FasL) exerts potent proapoptotic and proinflammatory actions on epidermal keratinocytes and has been implicated in the pathogenesis of eczema,…”
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Cell Death-Induced Activation of Epidermal Growth Factor Receptor in Keratinocytes: Implications for Restricting Epidermal Damage in Dermatitis by Iordanov, Mihail S., Sundholm, Aaron J., Simpson, Eric L., Hanifin, Jon M., Ryabinina, Olga P., Choi, Remy J., Korcheva, Veselina B., Schneider, Pascal, Magun, Bruce E.

“…Recent findings have implicated Fas/Fas ligand (FasL) in mediating the death of keratinocytes in spongiotic lesions. We asked whether dying keratinocytes could…”
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Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents by Newton, Dianne L, Hansen, Hans J, Liu, Huaitian, Ruby, Dale, Iordanov, Mihail S, Magun, Bruce E, Goldenberg, David M, Rybak, Susanna M

“…Targeting CD22 on human B-cells with a monoclonal antibody conjugated to a cytotoxic RNAse causes potent and specific killing of the lymphoma cells in vitro …”
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Loss of Cellular K+ Mimics Ribotoxic Stress by Iordanov, Mihail S., Magun, Bruce E.

“…The tumor promoter palytoxin has been found to activate the stress-activated protein kinase/c-Jun NH 2 -terminal kinase 1 (SAPK/JNK1), and it also potentiates,…”
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Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA by Iordanov, Mihail S., Pribnow, David, Magun, Jennifer L., Dinh, Thanh-Hoai, Pearson, Jean A., Chen, Steven Li-Ye, Magun, Bruce E.

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The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53 by Keller, David, Zeng, Xiaoya, Li, Xiaorong, Kapoor, Mini, Iordanov, Mihail S., Taya, Yoichi, Lozano, Guillermina, Magun, Bruce, Lu, Hua

“…Phosphorylation of p53 at serine 389 has been shown to be responsive uniquely to UV but not gamma irradiation. This report describes identification of the…”
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