Search Results - "Ioffe, Ella"

Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice by Burova, Elena, Hermann, Aynur, Waite, Janelle, Potocky, Terra, Lai, Venus, Hong, Seongwon, Liu, Matt, Allbritton, Omaira, Woodruff, Amy, Wu, Qi, D'Orvilliers, Amanda, Garnova, Elena, Rafique, Ashique, Poueymirou, William, Martin, Joel, Huang, Tammy, Skokos, Dimitris, Kantrowitz, Joel, Popke, Jon, Mohrs, Markus, MacDonald, Douglas, Ioffe, Ella, Olson, William, Lowy, Israel, Murphy, Andrew, Thurston, Gavin

“…The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on…”
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Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade by Eichten, Alexandra, Su, Jia, Adler, Alexander P, Zhang, Li, Ioffe, Ella, Parveen, Asma A, Yancopoulos, George D, Rudge, John, Lowy, Israel, Lin, Hsin Chieh, MacDonald, Douglas, Daly, Christopher, Duan, Xunbao, Thurston, Gavin

“…Anti-VEGF therapies benefit several cancer types, but drug resistance that limits therapeutic response can emerge. We generated cell lines from…”
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VEGF-Trap: A VEGF Blocker with Potent Antitumor Effects by Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, Boland, Patricia, Leidich, Ray, Hylton, Donna, Burova, Elena, Ioffe, Ella, Huang, Tammy, Radziejewski, Czeslaw, Bailey, Kevin, Fandl, James P., Daly, Tom, Wiegand, Stanley J., Yancopoulos, George D., Rudge, John S.

“…Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a…”
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Angiopoietin-2 Functions as an Autocrine Protective Factor in Stressed Endothelial Cells by Daly, Christopher, Pasnikowski, Elizabeth, Burova, Elena, Wong, Vivian, Aldrich, Thomas H., Griffiths, Jennifer, Ioffe, Ella, Daly, Thomas J., Fandl, James P., Papadopoulos, Nick, McDonald, Donald M., Thurston, Gavin, Yancopoulos, George D., Rudge, John S.

“…Angiopoietin (Ang)-2, a context-dependent agonist/antagonist for the vascular-specific Tie2 receptor, is highly expressed by endothelial cells at sites of…”
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1171 CLN-418, a clinical-stage B7H4 x 4–1BB bispecific antibody with potential to treat patients with a wide range of solid tumors by Ioffe, Ella, Mehta, Naveen K, Meetze, Kristan A, Shapiro, Irina M, Dobrowolska, Hanna, Huang, Bing, He, Yun, Baeuerle, Patrick A, Michaelson, Jennifer S

“…Background4–1BB is a key costimulatory receptor that mediates robust and durable tumor control by providing a secondary signal to antigen-experienced effector…”
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Angiopoietin-1 protects the adult vasculature against plasma leakage by Thurston, Gavin, Yancopoulos, George D, Rudge, John S, Ioffe, Ella, Zhou, Hao, Ross, Leorah, Croll, Susan D, Glazer, Nicole, Holash, Jocelyn, McDonald, Donald M

“…Pathological increases in vascular leakage lead to edema and swelling, causing serious problems in brain tumors, in diabetic retinopathy, after strokes, during…”
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Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1) by Daly, Christopher, Wong, Vivian, Burova, Elena, Wei, Yi, Zabski, Stephanie, Griffiths, Jennifer, Lai, Ka-Man, Lin, Hsin Chieh, Ioffe, Ella, Yancopoulos, George D, Rudge, John S

“…Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of vascular development, the molecular mechanisms underlying Ang-1…”
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Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice by Lin, Wen, Singh, Varan, Springer, Raynel, Choonoo, Gabrielle, Gupta, Namita, Patel, Aditi, Frleta, Davor, Zhong, Jun, Owczarek, Tomasz, Decker, Corinne, Macdonald, Lynn, Murphy, Andrew, Thurston, Gavin, Mohrs, Markus, Ioffe, Ella, Lu, Yi-Fen

“…Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of…”
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Pharmacologic Blockade of Angiopoietin-2 Is Efficacious against Model Hemangiomas in Mice by Perry, Betsy N., Govindarajan, Baskaran, Bhandarkar, Sulochana S., Knaus, Ulla G., Valo, Monika, Sturk, Celina, Carrillo, Carol O., Sohn, Allie, Cerimele, Francesca, Dumont, Dan, Losken, Albert, Williams, Joseph, Brown, Lawrence F., Tan, Xiaolian, Ioffe, Ella, Yancopoulos, George D., Arbiser, Jack L.

“…Hemangioma of infancy is the most common neoplasm of childhood. While hemangiomas are classic examples of angiogenesis, the angiogenic factors responsible for…”
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Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury by Long, David A., Price, Karen L., Ioffe, Ella, Gannon, Claire M., Gnudi, Luigi, White, Kathryn E., Yancopoulos, George D., Rudge, John S., Woolf, Adrian S.

“…The loss of interstitial capillaries is a feature of several experimental models of renal disease and this contributes to secondary kidney injury…”
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Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering by Davis, Samuel, Papadopoulos, Nick, Aldrich, Thomas H, Maisonpierre, Peter C, Huang, Tammy, Kovac, Lubomir, Xu, April, Leidich, Raymond, Radziejewska, Elzbieta, Rafique, Ashique, Goldberg, Judah, Jain, Vivek, Bailey, Kevin, Karow, Margaret, Fandl, Jim, Samuelsson, Steven J, Ioffe, Ella, Rudge, John S, Daly, Thomas J, Radziejewski, Czeslaw, Yancopoulos, George D

“…Angiopoietins are a recently discovered family of angiogenic factors that interact with the endothelial receptor tyrosine kinase Tie2, either as agonists…”
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Abnormal regulation of the leptin gene in the pathogenesis of obesity by Ioffe, E. (Howard Hughes Medical Institute, New York, NY.), Moon, B, Connolly, E, Friedman, J.M

“…A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested that in some cases abnormal regulation of the leptin gene in…”
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Complex N-glycans in Mgat1 null preimplantation embryos arise from maternal Mgat1 RNA by Ioffe, Ella, Liu, Yun, Stanley, Pamela

“…Mice with a null mutation in the Mgat1 gene lack N-acetyl-glucosaminyltransferase I (GlcNAc-TI; EC 2.4.1.101), and die at mid-gestation. This result suggested…”
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Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human PD-1xLAG-3 -Knockin Mice by Burova, Elena, Hermann, Aynur, Dai, Jie, Ullman, Erica, Halasz, Gabor, Potocky, Terra, Hong, Seongwon, Liu, Matt, Allbritton, Omaira, Woodruff, Amy, Pei, Jerry, Rafique, Ashique, Poueymirou, William, Martin, Joel, MacDonald, Douglas, Olson, William C, Murphy, Andrew, Ioffe, Ella, Thurston, Gavin, Mohrs, Markus

“…In the tumor microenvironment, multiple inhibitory checkpoint receptors can suppress T-cell function, thereby enabling tumor immune evasion. Blockade of one of…”
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Glycosyltransferase mutants: key to new insights in glycobiology by Stanley, P, Ioffe, E

“…Glycosyltransferases (Glyc-T's) catalyze the synthesis of the carbohydrate portions of glycoproteins, glycolipids, and proteoglycans. Most Glyc-T's transfer…”
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Abstract 3824: Antitumor activity of REGN4659, a fully human anti-CTLA-4 monoclonal antibody, against MC38.Ova tumors grown in immunocompetent human CTLA-4 knock-in mice by Burova, Elena, Allbritton, Omaira, Brydges, Susannah, Poueymirou, William, Durso, Robert, MacDonald, Douglas, Ioffe, Ella, Mohr, Markus, Olson, William, Thurston, Gavin

“…Abstract Cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) is an inhibitory checkpoint receptor that is expressed by activated conventional T cells and…”
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Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice by Li, Cai, Ioffe, Ella, Fidahusein, Naseem, Connolly, Eileen, Friedman, Jeffrey M.

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Abstract 1484: Combined treatment with anti-LAG-3 and anti-PD-1 fully human monoclonal antibodies inhibits tumor growth in immunocompetent double-humanized LAG-3/PD-1 mice by Burova, Elena, Allbritton, Omaira, Taduriyasas, Chandrika, Lai, Venus, Poueymirou, William, Papadopoulos, Nicholas, MacDonald, Douglas, Olson, William, Mohrs, Markus, Ioffe, Ella, Thurston, Gavin

“…Abstract Lymphocyte-activation gene 3 (LAG-3) receptor is expressed on activated CD4 and CD8 T cells, γδ T cells, Treg, NK, NKT, B and plasmacytoid dendritic…”
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Abstract 1484: Combined treatment with anti-LAG-3 and anti-PD-1 fully human monoclonal antibodies inhibits tumor growth in immunocompetent double-humanized LAG-3PD-1 mice by Burova, Elena, Allbritton, Omaira, Taduriyasas, Chandrika, Lai, Venus, Poueymirou, William, Papadopoulos, Nicholas, MacDonald, Douglas, Olson, William, Mohrs, Markus, Ioffe, Ella, Thurston, Gavin

“…Lymphocyte-activation gene 3 (LAG-3) receptor is expressed on activated CD4 and CD8 T cells, T cells, Treg, NK, NKT, B and plasmacytoid dendritic cells. LAG-3…”
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Abstract 5035: Blockade of VEGF with ziv-aflibercept (VEGF Trap) enhances anti-tumor efficacy of CTLA-4 blocking antibody in an Fc dependent manner by Burova, Elena, Ioffe, Ella, Taduriyasas, Chandrika, Allbritton, Omaira, Tyagi, Gaurav, Oyejide, Lekan, Rudge, John, Lowy, Israel, Thurston, Gavin

“…Abstract VEGF-dependent angiogenesis is required for tumor progression. Ziv-aflibercept (VEGF Trap) is a VEGF inhibitor, which exhibits potent antitumor…”
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