Search Results - "Ioannou, Yiannis A."

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth by Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B, Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D, O'Connor, Caitlin M, Hoon, Divya, Dhawan, Neil S, Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C, Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C, Yuan, Eric, Avelar, Rita A, Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M, McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C, Sears, Rosalie C, Chen, Edward Y, Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma'ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D, Brautigan, David L, Ioannou, Yiannis A, Xu, Wenqing, Chance, Mark R, Ohlmeyer, Michael, Narla, Goutham

“…Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have…”
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Cyclodextrin induces calcium-dependent lysosomal exocytosis by Chen, Fannie W, Li, Chunlei, Ioannou, Yiannis A

“…Cyclodextrins (CDs) have long been used to manipulate cellular cholesterol levels both in vitro and in vivo, but their direct effects at a cellular level are…”
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Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe by Temel, Ryan E, Tang, Weiqing, Ma, Yinyan, Rudel, Lawrence L, Willingham, Mark C, Ioannou, Yiannis A, Davies, Joanna P, Nilsson, Lisa-Mari, Yu, Liqing

“…Niemann-Pick C1-like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption…”
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PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport by Tamari, Farshad, Chen, Fannie W, Li, Chunlei, Chaudhari, Jagrutiben, Ioannou, Yiannis A

“…Activation of protein kinase C (PKC) has previously been shown to ameliorate the cholesterol transport defect in Niemann Pick Type C1 (NPC1) cells, presumably…”
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Inactivation of NPC1L1 Causes Multiple Lipid Transport Defects and Protects against Diet-induced Hypercholesterolemia by Davies, Joanna P., Scott, Catherine, Oishi, Kimihiko, Liapis, Anastasia, Ioannou, Yiannis A.

“…NPC1L1, a recently identified relative of Niemann-Pick C1, was characterized to determine its subcellular location and potential function(s). NPC1L1 was highly…”
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An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease by Munkacsi, Andrew B., Chen, Fannie W., Brinkman, Matthew A., Higaki, Katsumi, Gutiérrez, Giselle Domínguez, Chaudhari, Jagruti, Layer, Jacob V., Tong, Amy, Bard, Martin, Boone, Charles, Ioannou, Yiannis A., Sturley, Stephen L.

“…Niemann-Pick type C (NP-C) disease is a fatal lysosomal lipid storage disorder for which no effective therapy exists. A genome-wide, conditional synthetic…”
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MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site by Liapis, Anastasia, Chen, Fannie W, Davies, Joanna P, Wang, Rong, Ioannou, Yiannis A

“…MLN64 is an integral membrane protein localized to the late endosome and plasma membrane that is thought to function as a mediator of cholesterol transport…”
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Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction by Chen, Fannie W., Davies, Joanna P., Calvo, Raul, Chaudhari, Jagruti, Dolios, Georgia, Taylor, Mercedes K., Patnaik, Samarjit, Dehdashti, Jean, Mull, Rebecca, Dranchack, Patricia, Wang, Amy, Xu, Xin, Hughes, Emma, Southall, Noel, Ferrer, Marc, Wang, Rong, Marugan, Juan J., Ioannou, Yiannis A.

“…Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as…”
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Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8 by Tang, Weiqing, Ma, Yinyan, Jia, Lin, Ioannou, Yiannis A., Davies, Joanna P., Yu, Liqing

“…Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT)…”
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Transmembrane Molecular Pump Activity of Niemann-Pick C1 Protein by Davies, Joanna P., Chen, Fannie W., Ioannou, Yiannis A.

“…Niemann-Pick C1 (NPC1) disease is characterized by cholesterol accumulation in lysosomes and aberrant feedback regulation of cellular cholesterol homeostasis…”
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Niemann-Pick C1-Like 1 Is Required for an LXR Agonist to Raise Plasma HDL Cholesterol in Mice by Tang, Weiqing, Ma, Yinyan, Jia, Lin, Ioannou, Yiannis A, Davies, Joanna P, Yu, Liqing

“…OBJECTIVES—Activation of liver x receptor (LXR) raises plasma HDL-cholesterol (HDL-C) in mice. Interestingly, the LXR agonist GW3965 fails to raise plasma…”
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Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann-Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain by Suzuki, Michitaka, Sugimoto, Yuko, Ohsaki, Yuki, Ueno, Makoto, Kato, Shinsuke, Kitamura, Yukisato, Hosokawa, Hiroshi, Davies, Joanna P, Ioannou, Yiannis A, Vanier, Marie T, Ohno, Kousaku, Ninomiya, Haruaki

“…Niemann-Pick disease type C (NPC) is an inherited lipid storage disorder caused by mutations in NPC1 or NPC2 genes. Loss of function of either protein results…”
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Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment by Walter, Marc, Chen, Fannie W., Tamari, Farshad, Wang, Rong, Ioannou, Yiannis A.

“…Background information. Within the group of lysosomal storage diseases, NPC1 [NPC (Niemann‐Pick type C) 1] disease is a lipidosis characterized by excessive…”
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Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent by Temel, Ryan E., Brown, J. Mark, Ma, Yinyan, Tang, Weiqing, Rudel, Lawrence L., Ioannou, Yiannis A., Davies, Joanna P., Yu, Liqing

“…Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that…”
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NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein by Chen, Fannie W, Gordon, Ronald E, Ioannou, Yiannis A

“…NPC (Niemann-Pick type C) disease is a rare lipidosis characterized by the accumulation of LDL (low-density lipoprotein)-derived non-esterified cholesterol in…”
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Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes by Walter, Marc, Davies, Joanna P, Ioannou, Yiannis A

“…Niemann-Pick C (NPC) disease is a rare recessive lipidosis marked by excessive accumulation of LDL-derived free cholesterol and glycosphingolipids in the late…”
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Targeting of NPC1 to Late Endosomes Involves Multiple Signals, Including One Residing within the Putative Sterol-sensing Domain by Scott, Catherine, Higgins, Maureen E, Davies, Joanna P, Ioannou, Yiannis A

“…The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick type C1. NPC1…”
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Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes by Higgins, M E, Ioannou, Y A

“…It is well established that during the execution of the apoptotic cascade, activated caspase 3 releases sterol regulatory element-binding proteins (SREBP) from…”
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Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice by Labonté, Eric D, Camarota, Lisa M, Rojas, Juan C, Jandacek, Ronald J, Gilham, Dean E, Davies, Joanna P, Ioannou, Yiannis A, Tso, Patrick, Hui, David Y, Howles, Philip N

“…The impact of NPC1L1 and ezetimibe on cholesterol absorption are well documented. However, their potential consequences relative to absorption and metabolism…”
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Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease by Ziegler, Robin J, Li, Chester, Cherry, Maribeth, Zhu, Yunxiang, Hempel, Donna, van Rooijen, Nico, Ioannou, Yiannis A, Desnick, Robert J, Goldberg, Mark A, Yew, Nelson S, Cheng, Seng H

“…Systemic administration of recombinant adenoviral vectors for gene therapy of chronic diseases such as Fabry disease can be limited by dose-dependent toxicity…”
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