Search Results - "Ioannides, C. G."

Melanoma differentiation-associated gene-7 (mda-7)/interleukin (IL)-24 induces anticancer immunity in a syngeneic murine model by Miyahara, R, Banerjee, S, Kawano, K, Efferson, C, Tsuda, N, Miyahara, Y, Ioannides, C G, Chada, S, Ramesh, R

“…Previous studies have shown that the human melanoma differentiation-associated gene-7 (mda-7)/interleukin-24 (IL-24) has tumor-suppressor activity in vitro and…”
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Proliferative and cytokine responses to class II HER-2/neu-associated peptides in breast cancer patients by TUTTLE, T. M, ANDERSON, B. W, THOMPSON, W. E, LEE, J. E, SAHIN, A, SMITH, T. L, GRABSTEIN, K. H, WHARTON, J. T, IOANNIDES, C. G, MURRAY, J. L

“…Previous studies have characterized the reactivity of CD8+ CTLs with ovarian and breast cancer. There is little information about the antigens and epitopes…”
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Vaccine Implications of Folate Binding Protein, a Novel Cytotoxic T Lymphocyte-recognized Antigen System in Epithelial Cancers by PEOPLES, G. E, ANDERSON, B. W, LEER, T. V, MURRAY, J. L, KUDELKA, A. P, WHARTON, J. T, IOANNIDES, C. G

“…The immune system can be efficiently stimulated and targeted to specific antigens expressed exclusively or preferentially by experimental cancers. The foremost…”
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Peptide Priming of Cytolytic Activity to HER-2 Epitope 369–377 in Healthy Individuals by ANDERSON, Brett W, PEOPLES, George E, MURRAY, James L, GILLOGLY, Michael A, GERSHENSON, David M, IOANNIDES, Constantin G

“…The presence of tumor-reactive CTLs in tumor infiltrates and in the peripheral blood of cancer patients demonstrates an immune response against tumors that…”
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Clinical trials of HER-2/neu-specific vaccines by Murray, J L, Przepiorka, D, Ioannides, C G

“…Recently there has been a renewed interest in developing vaccines for use in cancer treatment. Part of this interest stems from a better understanding of the…”
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Increased sensitivity of adriamycin-selected tumor lines to CTL-mediated lysis results in enhanced drug sensitivity by FISK, B, IOANNIDES, C. G

“…The emergence of drug resistance to chemotherapeutic agents is a major cause of treatment failure in cancer therapy. Therefore, much effort has been aimed at…”
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Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells by Ioannides, CG, Freedman, RS, Platsoucas, CD, Rashed, S, Kim, YP

“…CTL clones were developed from tumor infiltrating lymphocytes (TIL) from the ascites of a patient with ovarian carcinoma by coculture of TIL with autologous…”
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Oxidant-Induced S-Glutathiolation Inactivates Protein Kinase C-α (PKC-α):  A Potential Mechanism of PKC Isozyme Regulation by Ward, Nancy E, Stewart, Jubilee R, Ioannides, Constantin G, O'Brian, Catherine A

“…Protein kinase C (PKC) isozymes are subject to inactivation by reactive oxygen species (ROS) through as yet undefined oxidative modifications of the isozyme…”
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Tumor cytolysis by lymphocytes infiltrating ovarian malignant ascites by IOANNIDES, C. G, PLATSOUCAS, C. D, RASHED, S, WHARTON, J. T, EDWARDS, C. L, FREEDMAN, R. S

“…Tumor-associated lymphocytes (TAL) were isolated from the ascitic fluid of patients with adenocarcinoma of the ovary. These cells proliferated and expanded by…”
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Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines by Fisk, B, Blevins, T L, Wharton, J T, Ioannides, C G

“…Synthetic peptide analogues of sequences in the HER-2 protooncogene (HER-2) were selected based on the presence of HLA-A2.1 anchor motifs to identify the…”
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Folate binding protein peptide 191-199 presented on dendritic cells can stimulate CTL from ovarian and breast cancer patients by Kim, D K, Lee, T V, Castilleja, A, Anderson, B W, Peoples, G E, Kudelka, A P, Murray, J L, Sittisomwong, T, Wharton, J T, Kim, J W, Ioannides, C G

“…Tumor associated lymphocytes (TAL) isolated from malignant ascites cultured in media containing interleukin-2 show antitumor responses. These antitumor…”
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Existent proliferative responses of peripheral blood mononuclear cells from healthy donors and ovarian cancer patients to HER-2 peptides by Fisk, B, Hudson, J M, Kavanagh, J, Wharton, J T, Murray, J L, Ioannides, C G, Kudelka, A P

“…Identifying target antigens for tumor-reactive T cells is important for understanding the mechanisms of tumor escape and developing novel anticancer therapies…”
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Identification of naturally processed human ovarian peptides recognized by tumor-associated CD8+ cytotoxic T lymphocytes by FISK, B, ANDERSON, B. W, GRAVITT, K. R, O'BRIAN, C. A, KUDELKA, A. P, MURRAY, J. L, WHARTON, J. T, IOANNIDES, C. G

“…Identification of naturally processed peptides recognized by tumorspecific CTLs may lead to epitope-specific tumor vaccines. Because these epitopes may be…”
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Ovarian and breast cytotoxic T lymphocytes can recognize peptides from the amino enhancer of split protein of the Notch complex by Babcock, B, Anderson, B.W, Papayannopoulos, I, Castilleja, A, Murray, J.L, Stifani, S, Kudelka, A.P, Wharton, J.T, Ioannides, C.G

“…In this study we investigated recognition by ovarian tumor associated lymphocyte (OVTAL), and breast tumor associated lymphocytes (BRTAL), of peptides…”
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Synthetic microRNA and double-stranded RNA targeting the 3'-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells by Tsuda, Naotake, Kawano, Kouichiro, Efferson, Clay L, Ioannides, Constantin G

“…MicroRNA (miRNA) are a class of non-coding RNAs found both in normal tissues and cancer cells. The natural miRNA, which target cancer genes for transcriptional…”
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Identification of activated tumor antigen-reactive CD8+ cells in healthy individuals by Lee, T V, Anderson, B W, Peoples, G E, Castilleja, A, Murray, J L, Gershenson, D M, Ioannides, C G

“…We investigated the ability of HER-2 peptide E75, which maps an immunodominant CTL epitope for ovarian and breast tumor-associated lymphocytes (TAL), to…”
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Selective usage of TCR V beta in tumor-specific CTL lines isolated from ovarian tumor-associated lymphocytes by Ioannides, C G, Freedman, R S

“…We have developed a series of six CTL lines exhibiting preferential killing of autologous tumour cells from tumour-associated lymphocytes (TALs) infiltrating…”
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Reduced recognition of metastatic melanoma cells by autologous MART-1 specific CTL: Relationship to TAP expression by MURRAY, J. L, HUDSON, J. M, ROSS, M. I, ZHANG, H.-Z, IOANNIDES, C. G

“…Class I expression in context with T-cell receptor expression is crucial for peptide presentation and induction of CD8+ cytotoxic T lymphocytes (CTL)…”
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Changes in an HER-2 peptide upregulating HLA-A2 expression affect both conformational epitopes and CTL recognition: implications for optimization of antigen presentation and tumor-specific CTL induction by Fisk, B, Savary, C, Hudson, J M, O'Brian, C A, Murray, J L, Wharton, J T, Ioannides, C G

“…The HER-2/neu protooncogene (HER-2) is overexpressed in a significant number of breast and ovarian tumors. Peptides of HER-2 sequence were recently found to…”
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Resveratrol Preferentially Inhibits Protein Kinase C-Catalyzed Phosphorylation of a Cofactor-Independent, Arginine-Rich Protein Substrate by a Novel Mechanism by Stewart, Jubilee R, Ward, Nancy E, Ioannides, Constantin G, O'Brian, Catherine A

“…Resveratrol, a polyphenolic natural product abundantly present in grape skins, is a candidate cancer chemopreventive agent that antagonizes each stage of…”
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