Search Results - "Invernizzi, Gaetano"

PyInteraph: A Framework for the Analysis of Interaction Networks in Structural Ensembles of Proteins by Tiberti, Matteo, Invernizzi, Gaetano, Lambrughi, Matteo, Inbar, Yuval, Schreiber, Gideon, Papaleo, Elena

“…In the last years, a growing interest has been gathering around the ability of Molecular Dynamics (MD) to provide insight into the paths of long-range…”
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Communication routes in ARID domains between distal residues in helix 5 and the DNA-binding loops by Invernizzi, Gaetano, Tiberti, Matteo, Lambrughi, Matteo, Lindorff-Larsen, Kresten, Papaleo, Elena

“…ARID is a DNA-binding domain involved in several transcriptional regulatory processes, including cell-cycle regulation and embryonic development. ARID domains…”
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The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model by Bonanomi, Marcella, Visentin, Cristina, Invernizzi, Gaetano, Tortora, Paolo, Regonesi, Maria Elena

“…Ataxin-3 (AT3) is a deubiquitinating enzyme that triggers an inherited neurodegenerative disorder, spinocerebellar ataxia type 3, when its polyglutamine…”
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Molecular determinants of enzyme cold adaptation: comparative structural and computational studies of cold- and warm-adapted enzymes by Papaleo, Elena, Tiberti, Matteo, Invernizzi, Gaetano, Pasi, Marco, Ranzani, Valeria

“…The identification of molecular mechanisms underlying enzyme cold adaptation is a hot-topic both for fundamental research and industrial applications. In the…”
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Diboronate Fluorophore for the Measurement of l‑Glucose and Other Carbohydrates and Its Interaction with Albumin by Solomos, Konstantinos, Tarus, Victoria, Kotek, Vladislav, Invernizzi, Gaetano, Hoeg-Jensen, Thomas

“…l-Glucose has recently been investigated as an artificial sweetener, but no facile method is established for the measurement of l-glucose. The commercial probe…”
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A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation by Natalello, Antonino, Frana, Anna Maria, Relini, Annalisa, Apicella, Alessandra, Invernizzi, Gaetano, Casari, Carlo, Gliozzi, Alessandra, Doglia, Silvia Maria, Tortora, Paolo, Regonesi, Maria Elena

“…The protein ataxin-3 consists of an N-terminal globular Josephin domain (JD) and an unstructured C-terminal region containing a stretch of consecutive…”
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Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs by Lambrughi, Matteo, Maiani, Emiliano, Aykac Fas, Burcu, Shaw, Gary S., Kragelund, Birthe B., Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, Gaetano, Papaleo, Elena

“…Ubiquitin is a small protein at the heart of many cellular processes, and several different protein domains are known to recognize and bind ubiquitin. A common…”
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The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli by Invernizzi, Gaetano, Aprile, Francesco A, Natalello, Antonino, Ghisleni, Andrea, Penco, Amanda, Relini, Annalisa, Doglia, Silvia M, Tortora, Paolo, Regonesi, Maria E

“…Several neurodegenerative diseases are triggered by proteins containing a polyglutamine (polyQ) stretch expanded beyond a critical threshold. Among these,…”
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Deactivation and unfolding are uncoupled in a bacterial lipase exposed to heat, low pH and organic solvents by Invernizzi, Gaetano, Casiraghi, Laura, Grandori, Rita, Lotti, Marina

“…The lipase from Burkholderia glumae (BGL) was incubated at variable temperature, pH and concentration of organic solvents, and the decrease of enzymatic…”
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Conformational diseases: structural studies of aggregation of polyglutamine proteins by Papaleo, Elena, Invernizzi, Gaetano

“…Protein misfolding and aggregation into insoluble amyloid deposits are often associated with neurodegenerative disorders. In particular, the polyglutamine…”
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Electrospray-ionization mass spectrometry as a tool for fast screening of protein structural properties by Grandori, Rita, Santambrogio, Carlo, Brocca, Stefania, Invernizzi, Gaetano, Lotti, Marina

“…Since the early 1990s, electrospray‐ionization mass spectrometry (ESI‐MS) has encountered growing interest as a complementary tool to established biochemical…”
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Protein aggregation: Mechanisms and functional consequences by Invernizzi, Gaetano, Papaleo, Elena, Sabate, Raimon, Ventura, Salvador

“…Understanding the mechanisms underlying protein misfolding and aggregation has become a central issue in biology and medicine. Compelling evidence show that…”
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(Dis)similarity Index To Compare Correlated Motions in Molecular Simulations by Tiberti, Matteo, Invernizzi, Gaetano, Papaleo, Elena

“…Molecular dynamics (MD) simulations are widely used to complement or guide experimental studies in the characterization of protein dynamics, thanks to…”
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Models for the study of inclusion bodies formation as a function of fermentation conditions and protein sequence by Gatti-Lafranconi, Pietro, Ami, Diletta, Natalello, Antonino, Invernizzi, Gaetano, de Marco, Ario, Doglia, Silvia, Lotti, Marina

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Nonspecificity fingerprints for clinical-stage antibodies in solution by Herling, Therese W, Invernizzi, Gaetano, Ausserwöger, Hannes, Bjelke, Jais Rose, Egebjerg, Thomas, Lund, Søren, Lorenzen, Nikolai, Knowles, Tuomas P J

“…Monoclonal antibodies (mAbs) have successfully been developed for the treatment of a wide range of diseases. The clinical success of mAbs does not solely rely…”
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Characterizing protein interactions in biomolecular phase separation by Ausserwöger, Hannes, Krainer, Georg, Qian, Daoyuan, Welsh, Timothy, Sneideris, Tomas, Schneider, Matthias M., Invernizzi, Gaetano, Herling, Therese W., Lorenzen, Nikolai, Knowles, Tuomas P.

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Conformational plasticity of the calcium-binding pocket in the Burkholderia glumae lipase: Remodeling induced by mutation of calcium coordinating residues by Papaleo, Elena, Invernizzi, Gaetano

“…Most bacterial lipases bind one or more Ca2+ atoms at different locations and are a suitable case of study for investigating structural effects related to…”
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Surface patches induce nonspecific binding and phase separation of antibodies by Ausserwöger, Hannes, Krainer, Georg, Welsh, Timothy J, Thorsteinson, Nels, de Csilléry, Ella, Sneideris, Tomas, Schneider, Matthias M, Egebjerg, Thomas, Invernizzi, Gaetano, Herling, Therese W, Lorenzen, Nikolai, Knowles, Tuomas P J

“…Nonspecific interactions are a key challenge in the successful development of therapeutic antibodies. The tendency for nonspecific binding of antibodies is…”
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Non-specificity as the sticky problem in therapeutic antibody development by Ausserwöger, Hannes, Schneider, Matthias M., Herling, Therese W., Arosio, Paolo, Invernizzi, Gaetano, Knowles, Tuomas P. J., Lorenzen, Nikolai

“…Antibodies are highly potent therapeutic scaffolds with more than a hundred different products approved on the market. Successful development of antibody-based…”
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Dynamics fingerprint and inherent asymmetric flexibility of a cold-adapted homodimeric enzyme. A case study of the Vibrio alkaline phosphatase by Papaleo, Elena, Renzetti, Giulia, Invernizzi, Gaetano, Ásgeirsson, Bjarni

“…Protein dynamics influence protein function and stability and modulate conformational changes. Such motions depend on the underlying networks of intramolecular…”
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