Search Results - "Inui, Hiroyasu"

Anti-GPIHBP1 Antibody-Positive Autoimmune Hyperchylomicronemia and Immune Thrombocytopenia by Tanaka, Katsunao, Koseki, Masahiro, Kato, Hisashi, Miyashita, Kazuya, Okada, Takeshi, Kanno, Kotaro, Saga, Ayami, Chang, Jiuyang, Omatsu, Takashi, Inui, Hiroyasu, Ohama, Tohru, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Primary hyperchylomicronemia is characterized by marked hypertriglyceridemia exceeding 1,000 mg/dL. It is caused by dysfunctional mutations in specific genes,…”
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Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction by Liu, Jingyi, Nishida, Makoto, Inui, Hiroyasu, Chang, Jiuyang, Zhu, Yinghong, Kanno, Kotaro, Matsuda, Hibiki, Sairyo, Masami, Okada, Takeshi, Nakaoka, Hajime, Ohama, Tohru, Masuda, Daisaku, Koseki, Masahiro, Yamashita, Shizuya, Sakata, Yasushi

“…Aim: A direct oral anti-coagulant, FXa inhibitor, has been applied to the clinical treatment of myocardial infarction (MI). Experimental studies in mice…”
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Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy by Kanno, Kotaro, Koseki, Masahiro, Chang, Jiuyang, Saga, Ayami, Inui, Hiroyasu, Okada, Takeshi, Tanaka, Katsunao, Asaji, Masumi, Zhu, Yinghong, Ide, Seiko, Saito, Shigeyoshi, Higo, Tomoaki, Okuzaki, Daisuke, Ohama, Tohru, Nishida, Makoto, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Yamashita, Shizuya, Sakata, Yasushi

“…Although patients with nonalcoholic fatty liver disease have been reported to have cardiac dysfunction, and appropriate model has not been reported. We…”
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Development and Clinical Application of an Enzyme-Linked Immunosorbent Assay for Oxidized High-Density Lipoprotein by Okada, Takeshi, Sumida, Mizuki, Ohama, Tohru, Katayama, Yuki, Saga, Ayami, Inui, Hiroyasu, Kanno, Kotaro, Masuda, Daisaku, Koseki, Masahiro, Nishida, Makoto, Sakata, Yasushi, Yamashita, Shizuya

“…Aims: HDL particles have various anti-atherogenic functions, whereas HDL from atherosclerotic patients was demonstrated to be dysfunctional. One possible…”
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Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice by Nishihara, Sae, Koseki, Masahiro, Tanaka, Katsunao, Omatsu, Takashi, Saga, Ayami, Sawabe, Hiroshi, Inui, Hiroyasu, Okada, Takeshi, Ohama, Tohru, Okuzaki, Daisuke, Kamada, Yoshihiro, Ono, Masafumi, Nishida, Makoto, Watanabe, Mikio, Sakata, Yasushi

“…We previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular…”
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Twin Study: The Factors Affecting the Serum LDL-C and HDL-C Levels and an RNA-Seq Analysis in Mononuclear Cells in Monozygotic Twins by Nishihara, Sae, Koseki, Masahiro, Tanaka, Katsunao, Omatsu, Takashi, Sawabe, Hiroshi, Inui, Hiroyasu, Saga, Ayami, Okada, Takeshi, Higo, Tomoaki, Ohama, Tohru, Nishida, Makoto, Sakata, Yasushi, Watanabe, Mikio, Group, Osaka Twin Research

“…Aim: A twin study is a valuable tool for elucidating the acquired factors against lifestyle diseases such as dyslipidemia, diabetes mellitus, and obesity. We…”
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DEVELOPMENT AND CLINICAL APPLICATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY FOR OXIDIZED HIGH DENSITY LIPOPROTEIN by Okada, Takeshi, Ohama, Tohru, Saga, Ayami, Inui, Hiroyasu, Kanno, Kotaro, Koseki, Masahiro, Nishida, Makoto, Sakata, Hasashi, Yamashita, Shizuya

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A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice by Saga, Ayami, Koseki, Masahiro, Kanno, Kotaro, Chang, Jiuyang, Higo, Tomoaki, Okuzaki, Daisuke, Okada, Takeshi, Inui, Hiroyasu, Asaji, Masumi, Tanaka, Katsunao, Omatsu, Takashi, Nishihara, Sae, Zhu, Yinghong, Ito, Kaori, Hattori, Hiroaki, Ichi, Ikuyo, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Ohama, Tohru, Hikoso, Shungo, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Patients with psoriasis are at a higher risk of developing nonalcoholic fatty liver disease. We previously identified an oxidized derivative of cholesterol,…”
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Dietary Oxysterol, 7-Ketocholesterol Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice by Chang, Jiuyang, Koseki, Masahiro, Saga, Ayami, Kanno, Kotaro, Higo, Tomoaki, Okuzaki, Daisuke, Okada, Takeshi, Inui, Hiroyasu, Tanaka, Katsunao, Asaji, Masumi, Zhu, Yinghong, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Ichi, Ikuyo, Ohama, Tohru, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Non-alcoholic fatty liver disease is strongly associated with obese and type 2 diabetes. It has been reported that an oxidized cholesterol, 7-ketocholesterol…”
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Abstract 13005: Depletion of XCR1+ Conventional Dendritic Cell After Myocardial Infarction Improved Adverse Cardiac Remodeling via CXCR3 Chemokine Signaling by Inui, Hiroyasu, Nishida, Makoto, Saga, Ayami, Omatsu, Takashi, Tanaka, Katsunao, Okada, Takeshi, Ohama, Tohru, Koseki, Masahiro, Yamashita, Shizuya, Sakata, Yasushi

“…Abstract only Introduction: We have demonstrated immune reactions of probucol treatment on cardiac remodeling using SR-BI KO/ApoeR61 h/h (SRBI KO) mice in…”
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Abstract 12525: Synergistic Effects of Pitavastatin and Pemafibrate on Hepatic Steatosis and Inflammation in Ldlr+/- Mice Fed Fat Diet by Tanaka, Katsunao, Koseki, Masahiro, Okada, Takeshi, Inui, Hiroyasu, Jiuyang, Chang, Omatsu, Takashi, Saga, Ayami, Ohama, Tohru, Nishida, Makoto, Sakata, Yasushi

“…IntroductionThe combination therapy of statin, ezetimibe and PCSK9 inhibitors enables us to reduce serum LDL-C and risk of atherosclerotic diseases. However,…”
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Abstract 15512: The Hepatic Lipid Type and Content Had an Impact on Hepatic Inflammation and Fibrosis in Streptozotocin-Induced Diabetic Mice by Koseki, Masahiro, Chang, Jiuyang, Saga, Ayami, Kanno, Kotaro, Tanaka, Katsunao, Omatsu, Takashi, Okada, Takeshi, Inui, Hiroyasu, Ohama, Tohru, Nishida, Makoto, Sakata, Yasushi

“…IntroductionIt has been reported that nonalcoholic fatty liver disease is an independent risk factor for cardiovascular diseases. We have recently demonstrated…”
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Abstract 10144: Xcr1+ Dendritic Cell-Induced Cd4+ T Helper-1 Activation Leads to Exacerbation of Remodeling After Myocardial Infarction by Inui, Hiroyasu, Nishida, Makoto, Asaji, Masumi, Saga, Ayami, Kanno, Kotaro, Jiuyang, Chang, Zhu, Yinghong, Okada, Takeshi, Tanaka, Katsunao, Ohama, Tohru, Koseki, Masahiro, Yamashita, Shizuya, Sakata, Yasushi

“…Background and AimImmune response including T cell activation after myocardial infarction (MI) is important mechanism in cardiac remodeling. We established a…”
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Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through complement C1q-induced β-catenin activation by Zhu, Yinghong, Ohama, Tohru, Kawase, Ryota, Chang, Jiuyang, Inui, Hiroyasu, Kanno, Kotaro, Okada, Takeshi, Masuda, Daisaku, Koseki, Masahiro, Nishida, Makoto, Sakata, Yasushi, Yamashita, Shizuya

“…Age-related cardiac hypertrophy and subsequent heart failure are predicted to become increasingly serious problems in aging populations. Progranulin (PGRN)…”
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Abstract 12689: Targeted Exon Sequencing of Lipid-related Genes in Patients With Clinically Diagnosed Familial Hypercholesterolemia by Okada, Takeshi, Koseki, Masahiro, Nishida, Makoto, Tanaka, Katsunao, Inui, Hiroyasu, Kanno, Kotaro, Saga, Ayami, Ohama, Tohru, Kujiraoka, Takeshi, Hattori, Hiroaki, Yamashita, Shizuya, Sakata, Yasushi

“…BackgroundFamilial hypercholesterolemia (FH) is at high risk of premature coronary artery disease (CAD). Japan Atherosclerosis Society (JAS) has published…”
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Abstract 11850: Targeted Next-Generation Sequencing of 36 Lipid-Related Genes in Patients With Clinically Diagnosed Familial Hypercholesterolemia by Okada, Takeshi, Koseki, Masahiro, Nishida, Makoto, Omatsu, Takashi, Tanaka, Katsunao, Inui, Hiroyasu, Chang, Jiuyang, Kanno, Kotaro, Saga, Ayami, Ohama, Tohru, Ishihara, Mitsuaki, Kujiraoka, Takeshi, Hattori, Hiroaki, Masuda, Daisaku, Yamashita, Shizuya, Sakata, Yasushi

“…BackgroundFamilial hypercholesterolemia (FH) is characterized by elevated serum low-density lipoprotein cholesterol (LDL-C) levels and premature coronary…”
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XCR1+ conventional dendritic cell-induced CD4+ T helper 1 cell activation exacerbates cardiac remodeling after ischemic myocardial injury by Inui, Hiroyasu, Nishida, Makoto, Ichii, Michiko, Nakaoka, Hajime, Asaji, Masumi, Ide, Seiko, Saito, Shigeyoshi, Saga, Ayami, Omatsu, Takashi, Tanaka, Katsunao, Kanno, Kotaro, Chang, Jiuyang, Zhu, Yinghong, Okada, Takeshi, Okuzaki, Daisuke, Matsui, Takahiro, Ohama, Tohru, Koseki, Masahiro, Morii, Eiichi, Hosen, Naoki, Yamashita, Shizuya, Sakata, Yasushi

“…Cardiac remodeling has no established therapies targeting inflammation. CD4+ T-cell subsets have been reported to play significant roles in healing process…”
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Anti-GPIHBP1 Antibody-Positive Autoimmune Hyperchylomicronemia and Immune Thrombocytopenia by Tanaka, Katsunao, Koseki, Masahiro, Kato, Hisashi, Miyashita, Kazuya, Okada, Takeshi, Kanno, Kotaro, Saga, Ayami, Chang, Jiuyang, Omatsu, Takashi, Inui, Hiroyasu, Ohama, Tohru, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Primary hyperchylomicronemia is characterized by marked hypertriglyceridemia exceeding 1,000 mg/dL. It is caused by dysfunctional mutations in specific genes,…”
Get full text

Development and Clinical Application of an Enzyme-Linked Immunosorbent Assay for Oxidized High-Density Lipoprotein by Okada, Takeshi, Sumida, Mizuki, Ohama, Tohru, Katayama, Yuki, Saga, Ayami, Inui, Hiroyasu, Kanno, Kotaro, Masuda, Daisaku, Koseki, Masahiro, Nishida, Makoto, Sakata, Yasushi, Yamashita, Shizuya

“…Aims: HDL particles have various anti-atherogenic functions, whereas HDL from atherosclerotic patients was demonstrated to be dysfunctional. One possible…”
Get full text

Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction by Liu, Jingyi, Nishida, Makoto, Inui, Hiroyasu, Chang, Jiuyang, Zhu, Yinghong, Kanno, Kotaro, Matsuda, Hibiki, Sairyo, Masami, Okada, Takeshi, Nakaoka, Hajime, Ohama, Tohru, Masuda, Daisaku, Koseki, Masahiro, Yamashita, Shizuya, Sakata, Yasushi

“…Aim: A direct oral anti-coagulant, FXa inhibitor, has been applied to the clinical treatment of myocardial infarction (MI). Experimental studies in mice…”
Get full text