The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease

The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease

Membrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles. This process is required for cells to mature and function properly, allowing them to adapt to their s...

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Published in:Journal of neuroscience research Vol. 102; no. 1; pp. e25261 - n/a
Main Authors: Abdul‐Rahman, Toufik, Ghosh, Shankhaneel, Kalmanovich, Jacob B., Awuah, Andrew Wireko, Zivcevska, Marija, Khalifa, Samar, Bassey, Esther Edet, Ali, Namarig Alnil, Ferreira, Matheus Mendes dos Santos, Umar, Tungki Pratama, Garg, Neil, Nweze, Victor Nnanna, Inturu, Venkata Sai Sulekhya, Abdelwahab, Maya Magdy, Kurian, Sneha, Alexiou, Athanasios, Alfaleh, Mohammed, Alqurashi, Thamer M. A., Ashraf, Ghulam Md
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-01-2024
Subjects:
Alzheimer's disease
Cell membranes
Membrane trafficking
Membranes
Movement disorders
Neurodegenerative diseases
neurodegenerative disorders
Nexin
Parkinson's disease
Pathogenesis
Peptides
retromer
Therapeutic applications
Parkinson's disease
retromer
neurodegenerative disorders
Alzheimer's disease
membrane trafficking
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Summary:Membrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles. This process is required for cells to mature and function properly, allowing them to adapt to their surroundings. The retromer complex is a complex composed of nexin proteins and peptides that play a vital role in the endosomal pathway of membrane trafficking. In humans, any interference in normal membrane trafficking or retromer complex can cause profound changes such as those seen in neurodegenerative disorders such as Alzheimer's and Parkinson's. Several studies have explored the potential causative mechanisms in developing both disease processes; however, the role of retromer trafficking in their pathogenesis is becoming increasingly significant with promising therapeutic applications. This manuscript describes the processes involved in membrane transport and the roles of the retromer in the onset and progression of Alzheimer's and Parkinson's. Moreover, we will also explore how these aberrant mechanisms may serve as possible avenues for treatment development in both diseases and the prospect of its future application.
Bibliography:Edited by Junie Paula Warrington and Huaye Zhang. Retrieved by Rekha Khandia, Niraj Kumar Jha, Ping‐Yue Pan, and Qian Cai.
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ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.25261