Search Results - "Inturrisi, Charles"

Cav1.3 L-type Ca2+ channel-activated CaMKII/ERK2 pathway in the ventral tegmental area is required for cocaine conditioned place preference by Martínez-Rivera, Arlene, Hao, Jin, Rice, Richard, Inturrisi, Charles E., Rajadhyaksha, Anjali M.

“…We have previously demonstrated that pharmacological blockade of ventral tegmental area (VTA) Cav1.3 L-type calcium channels (LTCCs) using Cav1.2…”
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Esmethadone-HCl (REL-1017): a promising rapid antidepressant by Fava, Maurizio, Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Bettini, Ezio, Comai, Stefano, Alimonti, Andrea, Bifari, Francesco, Pani, Luca, Folli, Franco, Guidetti, Clotilde, Furlan, Alberto, Sgrignani, Jacopo, Locatelli, Patrizia, Cavalli, Andrea, O’Gorman, Cedric, Traversa, Sergio, Inturrisi, Charles E., Pappagallo, Marco, Manfredi, Paolo L.

“…This review article presents select recent studies that form the basis for the development of esmethadone into a potential new drug. Esmethadone is a promising…”
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REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial by Fava, Maurizio, Stahl, Stephen, Pani, Luca, De Martin, Sara, Pappagallo, Marco, Guidetti, Clotilde, Alimonti, Andrea, Bettini, Ezio, Mangano, Richard M, Wessel, Thomas, de Somer, Marc, Caron, Judy, Vitolo, Ottavio V, DiGuglielmo, Gina R, Gilbert, Adam, Mehta, Hiren, Kearney, Morgan, Mattarei, Andrea, Gentilucci, Marco, Folli, Franco, Traversa, Sergio, Inturrisi, Charles E, Manfredi, Paolo L

“…The purpose of this study was to examine the effects of REL-1017 (esmethadone), a novel -methyl-d-aspartate receptor (NMDAR) channel blocker, in patients with…”
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Comment on “Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status by Pappagallo, Marco, Inturrisi, Charles E., Manfredi, Paolo L.

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The N-Methyl-D-Aspartate Receptor Antagonist d-Methadone Acutely Improves Depressive-Like Behavior in the Forced Swim Test Performance of Rats by Hanania, Taleen, Manfredi, Paolo, Inturrisi, Charles, Vitolo, Ottavio V.

“…d-Methadone (dextromethadone) is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist that binds to the dizocilpine (MK-801)-binding site of the…”
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Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling by Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Bettini, Ezio, Pani, Luca, Guidetti, Clotilde, Folli, Franco, de Somer, Marc, Traversa, Sergio, Inturrisi, Charles E., Pappagallo, Marco, Gentilucci, Marco, Alimonti, Andrea, Fava, Maurizio, Manfredi, Paolo L.

“…This article presents a mechanism of action hypothesis to explain the rapid antidepressant effects of esmethadone (REL-1017) and other uncompetitive…”
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The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users by Shram, Megan J., Henningfield, Jack E., Apseloff, Glen, Gorodetzky, Charles W., De Martin, Sara, Vocci, Frank L., Sapienza, Frank L., Kosten, Thomas R., Huston, Jeff, Buchhalter, August, Ashworth, Judy, Lanier, Ryan, Folli, Franco, Mattarei, Andrea, Guidetti, Clotilde, Comai, Stefano, O’Gorman, Cedric, Traversa, Sergio, Inturrisi, Charles E., Manfredi, Paolo L., Pappagallo, Marco

“…Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2,…”
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Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone' by Pappagallo, Marco, Kosten, Thomas R, Gorodetzky, Charles W, Vocci, Frank J, Sapienza, Frank L, De Martin, Sara, Comai, Stefano, Mattarei, Andrea, Inturrisi, Charles E, Manfredi, Paolo L

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REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study by De Martin, Sara, Gabbia, Daniela, Folli, Franco, Bifari, Francesco, Fiorina, Paolo, Ferri, Nicola, Stahl, Stephen, Inturrisi, Charles E, Pappagallo, Marco, Traversa, Sergio, Manfredi, Paolo L

“…Brain-derived neurotrophic factor (BDNF), a neurotrophin widely expressed in the central nervous system, exhibits important effects on neural plasticity. BDNF…”
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Efficacy and Safety of Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants: A Phase 3 Randomized Controlled Trial by Fava, Maurizio, Stahl, Stephen M, Pani, Luca, De Martin, Sara, Cutler, Andrew J, Maletic, Vladimir, Gorodetzky, Charles W, Vocci, Frank J, Sapienza, Frank L, Kosten, Thomas R, Kröger, Cornelia, Champasa, Paggard, O'Gorman, Cedric, Guidetti, Clotilde, Alimonti, Andrea, Comai, Stefano, Mattarei, Andrea, Folli, Franco, Bushnell, David, Traversa, Sergio, Inturrisi, Charles E, Manfredi, Paolo L, Pappagallo, Marco

“…To test esmethadone (REL-1017) as adjunctive treatment in patients with major depressive disorder (MDD) and inadequate response to standard antidepressants. In…”
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Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism by Ferri, Nicola, De Martin, Sara, Stuart, James, Traversa, Sergio, Folli, Franco, Pappagallo, Marco, O’Gorman, Cedric, Guidetti, Clotilde, Mattarei, Andrea, Inturrisi, Charles E., Manfredi, Paolo L.

“…Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic…”
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REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats by Henningfield, Jack, Gauvin, David, Bifari, Francesco, Fant, Reginald, Shram, Megan, Buchhalter, August, Ashworth, Judy, Lanier, Ryan, Pappagallo, Marco, Inturrisi, Charles, Folli, Franco, Traversa, Sergio, Manfredi, Paolo L.

“…REL-1017 (esmethadone, d -methadone) is the opioid-inactive d-isomer of racemic d,l -methadone. REL-1017 may exert antidepressant effects via uncompetitive N…”
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Pharmacokinetics, Tolerability, and Safety of Esmethadone in Subjects with Chronic Kidney Disease or Hepatic Impairment by Ferri, Nicola, De Martin, Sara, Stuart, James, Traversa, Sergio, Mattarei, Andrea, Comai, Stefano, Folli, Franco, Pappagallo, Marco, Guidetti, Clotilde, Inturrisi, Charles E., Manfredi, Paolo L.

“…Background and Objectives Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is a low potency N -methyl- D -aspartate (NMDA)…”
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The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin by Bettini, Ezio, De Martin, Sara, Mattarei, Andrea, Pappagallo, Marco, Stahl, Stephen M., Bifari, Francesco, Inturrisi, Charles E., Folli, Franco, Traversa, Sergio, Manfredi, Paolo L.

“…REL-1017 (esmethadone) is a novel N-methyl-D-aspartate receptor (NMDAR) antagonist and promising rapid antidepressant candidate. Using fluorometric imaging…”
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Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors by Bettini, Ezio, Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Sgrignani, Jacopo, Carignani, Corrado, Nola, Selena, Locatelli, Patrizia, Pappagallo, Marco, Inturrisi, Charles E., Bifari, Francesco, Cavalli, Andrea, Alimonti, Andrea, Pani, Luca, Fava, Maurizio, Traversa, Sergio, Folli, Franco, Manfredi, Paolo L.

“…Excessive Ca2+ currents via N-methyl-D-aspartate receptors (NMDARs) have been implicated in many disorders. Uncompetitive NMDAR channel blockers are an…”
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Clinical Pharmacology of Opioids for Pain by Inturrisi, Charles E

“…The pharmacological effects of the opioid analgesics are derived from their complex interactions with three opioid receptor types (μ, δ, and κ; morphine is an…”
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Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak by Standifer, Kelly M., Inturrisi, Charles E., Foley, Kathleen M., Pan, Ying-Xian

“…This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD, PhD. Homage to the breadth and depth of his work (~ 450…”
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Stabilization of the μ-Opioid Receptor by Truncated Single Transmembrane Splice Variants through a Chaperone-like Action by Xu, Jin, Xu, Ming, Brown, Taylor, Rossi, Grace C., Hurd, Yasmin L., Inturrisi, Charles E., Pasternak, Gavril W., Pan, Ying-Xian

“…The μ-opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing, as illustrated by the identification of an array of splice variants…”
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N-Methyl- d-aspartate receptor (NMDAR) independent maintenance of inflammatory pain by Weyerbacher, Amanda R., Xu, Qinghao, Tamasdan, Cristina, Shin, Sarah J., Inturrisi, Charles E.

“…Following peripheral inflammation, NMDA receptor (NMDAR) activation in spinal cord dorsal horn neurons facilitates the generation of pain in response to low…”
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Pain assessment, management, and control among patients 65 years or older receiving hospice care in the U.S by Cea, Meagan, M.A, Reid, M.C., M.D, Inturrisi, Charles, Ph.D, Witkin, Lisa R., M.D, Prigerson, Holly G., Ph.D, Bao, Yuhua, Ph.D

“…Abstract Context Knowledge is limited regarding pain assessment and management practices, as well as pain-related outcomes in hospice care. Objectives To…”
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