Search Results - "International journal of oncology"

From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review) by Schirrmacher, Volker

“…The side effects of systemic chemotherapy used to treat cancer are often severe. For decades, oncologists have focused on treating the tumor, which may result…”
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Triple‑negative breast cancer therapy: Current and future perspectives (Review) by Won, Kwang-Ai, Spruck, Charles

“…Triple-negative breast cancer (TNBC) accounts for 10-15% of all breast cancer cases. TNBCs lack estrogen and progesterone receptors and express low levels of…”
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Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application (Review) by Chiangjong, Wararat, Chutipongtanate, Somchai, Hongeng, Suradej

“…Cancer is currently ineffectively treated using therapeutic drugs, and is also able to resist drug action, resulting in increased side effects following drug…”
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Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer (Review) by He, Jingyi, Huang, Zhengrong, Han, Linzhi, Gong, Yan, Xie, Conghua

“…Targeted therapy with epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitors (TKIs) is a standard modality of the 1st‑line treatments for patients…”
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The Akt pathway in oncology therapy and beyond (Review) by Nitulescu, George Mihai, Van De Venter, Maryna, Nitulescu, Georgiana, Ungurianu, Anca, Juzenas, Petras, Peng, Qian, Olaru, Octavian Tudorel, Grădinaru, Daniela, Tsatsakis, Aristides, Tsoukalas, Dimitris, Spandidos, Demetrios A, Margina, Denisa

“…Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell death and survival, playing a pivotal role in multiple…”
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The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells by Taketo, Kosuke, Konno, Masamitsu, Asai, Ayumu, Koseki, Jun, Toratani, Masayasu, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi, Ogawa, Kazuhiko

“…N6-methyladenosine (m6A) is the most abundant epitranscriptome modification in mammalian mRNA. Recent years have seen substantial progress in m6A…”
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Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review) by Katoh, Masaru

“…Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic, epithelial-mesenchymal,…”
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The post-translational modification, SUMOylation, and cancer (Review) by Han, Zhi-Jian, Feng, Yan-Hu, Gu, Bao-Hong, Li, Yu-Min, Chen, Hao

“…SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA…”
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Cancer-associated stroke: Pathophysiology, detection and management (Review) by Dardiotis, Efthimios, Aloizou, Athina-Maria, Markoula, Sofia, Siokas, Vasileios, Tsarouhas, Konstantinos, Tzanakakis, Georgios, Libra, Massimo, Kyritsis, Athanassios P, Brotis, Alexandros G, Aschner, Michael, Gozes, Illana, Bogdanos, Dimitrios P, Spandidos, Demetrios A, Mitsias, Panayiotis D, Tsatsakis, Aristidis

“…Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of…”
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Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis by Yamaguchi, Yuki, Kasukabe, Takashi, Kumakura, Shunichi

“…Pancreatic cancer is one of the most lethal types of cancer with a mortality rate of almost 95%. Treatment with current chemotherapeutic drugs has limited…”
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Exosome-mediated transfer of lncRNA‑SNHG14 promotes trastuzumab chemoresistance in breast cancer by Dong, Huaying, Wang, Wei, Chen, Ru, Zhang, Yu, Zou, Kejian, Ye, Mulin, He, Xionghui, Zhang, Fan, Han, Jing

“…Currently, resistance to trastuzumab, a human epidermal growth factor receptor 2 (HER2) inhibitor, has become an important obstacle to improving the clinical…”
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Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review) by NITULESCU, GEORGE MIHAI, MARGINA, DENISA, JUZENAS, PETRAS, PENG, QIAN, OLARU, OCTAVIAN TUDOREL, SALOUSTROS, EMMANOUIL, FENGA, CONCETTINA, SPANDIDOS, DEMETRIOS A, LIBRA, MASSIMO, TSATSAKIS, ARISTIDIS M

“…Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are…”
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The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer by Zhang, Nan, Zeng, Yuanyuan, Du, Wenwen, Zhu, Jianjie, Shen, Dan, Liu, Zeyi, Huang, Jian-an

“…Negative regulation of the signal mediated by the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway can effectively inhibit the…”
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Cancer‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway by Chen, Shuhai, Morine, Yuji, Tokuda, Kazunori, Yamada, Shinichiro, Saito, Yu, Nishi, Masaaki, Ikemoto, Tetsuya, Shimada, Mitsuo

“…Targeting the tumor stroma is an important strategy in cancer treatment. Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are two…”
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Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines by Pilco-Ferreto, Nesstor, Calaf, Gloria M

“…Breast cancer is one of the leading causes of mortality among women worldwide due to aggressive behavior, early metastasis, resistance to existing…”
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Oncological role of HMGA2 (Review) by Zhang, Shizhen, Mo, Qiuping, Wang, Xiaochen

“…The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription factor that modulates the transcription of several genes by binding to…”
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Serine, glycine and one‑carbon metabolism in cancer (Review) by Pan, Sijing, Fan, Ming, Liu, Zhangnan, Li, Xia, Wang, Huijuan

“…Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell survival and rapid proliferation, and of high clinical relevance…”
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GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review) by Cui, Jian, Li, Guoqing, Yin, Jie, Li, Linwei, Tan, Yue, Wei, Haoran, Liu, Bang, Deng, Lihong, Tang, Jialu, Chen, Yonglin, Yi, Lan

“…Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene that plays an important regulatory role in detoxification, anti‑oxidative damage,…”
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Circulating tumor cell clusters: What we know and what we expect (Review) by Hong, Yupeng, Fang, Francia, Zhang, Qi

“…The major cause of cancer-associated mortality is tumor metastasis, a disease that is far from understood. Many studies have observed circulating tumor cells…”
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Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis by Zhang, Wei, Ou, Xiaoxuan, Wu, Xiaohua

“…Ovarian cancer remains the most lethal type of cancer among all gynecological malignancies. The majority of patients are diagnosed with ovarian cancer at the…”
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