Search Results - "International journal of molecular sciences"

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies by Juan, Celia Andrés, Pérez de la Lastra, José Manuel, Plou, Francisco J, Pérez-Lebeña, Eduardo

“…Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature…”
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Pathophysiology of Type 2 Diabetes Mellitus by Galicia-Garcia, Unai, Benito-Vicente, Asier, Jebari, Shifa, Larrea-Sebal, Asier, Siddiqi, Haziq, Uribe, Kepa B, Ostolaza, Helena, Martín, César

“…Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by…”
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Macrophage Polarization States in the Tumor Microenvironment by Boutilier, Ava J., Elsawa, Sherine F.

“…The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages,…”
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Silver Nanoparticles and Their Antibacterial Applications by Bruna, Tamara, Maldonado-Bravo, Francisca, Jara, Paul, Caro, Nelson

“…Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The…”
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Analytical Methods Used in Determining Antioxidant Activity: A Review by Munteanu, Irina Georgiana, Apetrei, Constantin

“…The study of antioxidants and their implications in various fields, from food engineering to medicine and pharmacy, is of major interest to the scientific…”
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The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation by Kelley, Nathan, Jeltema, Devon, Duan, Yanhui, He, Yuan

“…The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines…”
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The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics by Jang, Dan-In, Lee, A-Hyeon, Shin, Hye-Yoon, Song, Hyo-Ryeong, Park, Jong-Hwi, Kang, Tae-Bong, Lee, Sang-Ryong, Yang, Seung-Hoon

“…Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have…”
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The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases by Cabral-Pacheco, Griselda A, Garza-Veloz, Idalia, Castruita-De la Rosa, Claudia, Ramirez-Acuña, Jesús M, Perez-Romero, Braulio A, Guerrero-Rodriguez, Jesús F, Martinez-Avila, Nadia, Martinez-Fierro, Margarita L

“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost…”
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Metabolic Syndrome: Updates on Pathophysiology and Management in 2021 by Fahed, Gracia, Aoun, Laurence, Bou Zerdan, Morgan, Allam, Sabine, Bou Zerdan, Maroun, Bouferraa, Youssef, Assi, Hazem I

“…Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin resistance, atherogenic dyslipidemia, central obesity, and…”
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Mechanisms of Multidrug Resistance in Cancer Chemotherapy by Bukowski, Karol, Kciuk, Mateusz, Kontek, Renata

“…Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the past decades, chemotherapy…”
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NRF2, a Transcription Factor for Stress Response and Beyond by He, Feng, Ru, Xiaoli, Wen, Tao

“…Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through…”
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Cytokines in Inflammatory Disease by Kany, Shinwan, Vollrath, Jan Tilmann, Relja, Borna

“…This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines…”
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Molecular Docking: Shifting Paradigms in Drug Discovery by Pinzi, Luca, Rastelli, Giulio

“…Molecular docking is an established in silico structure-based method widely used in drug discovery. Docking enables the identification of novel compounds of…”
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Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies by Machlowska, Julita, Baj, Jacek, Sitarz, Monika, Maciejewski, Ryszard, Sitarz, Robert

“…Gastric cancer (GC) is one of the most common malignancies worldwide and it is the fourth leading cause of cancer-related death. GC is a multifactorial…”
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Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms by Anjum, Anam, Yazid, Muhammad Da'in, Fauzi Daud, Muhammad, Idris, Jalilah, Ng, Angela Min Hwei, Selvi Naicker, Amaramalar, Ismail, Ohnmar Htwe Rashidah, Athi Kumar, Ramesh Kumar, Lokanathan, Yogeswaran

“…Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Its pathophysiology…”
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The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis by Ghasemi, Mahshid, Turnbull, Tyron, Sebastian, Sonia, Kempson, Ivan

“…The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity; however, it is commonly applied and interpreted erroneously. We…”
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Regulation of Plant Responses to Salt Stress by Zhao, Shuangshuang, Zhang, Qikun, Liu, Mingyue, Zhou, Huapeng, Ma, Changle, Wang, Pingping

“…Salt stress is a major environmental stress that affects plant growth and development. Plants are sessile and thus have to develop suitable mechanisms to adapt…”
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TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues by Bartha, Áron, Győrffy, Balázs

“…Genes showing higher expression in either tumor or metastatic tissues can help in better understanding tumor formation and can serve as biomarkers of…”
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Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives by Kuriakose, Diji, Xiao, Zhicheng

“…Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with…”
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Understanding MAPK Signaling Pathways in Apoptosis by Yue, Jicheng, López, José M

“…MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these…”
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