Search Results - "International journal of antimicrobial agents"

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial by Gautret, Philippe, Lagier, Jean-Christophe, Parola, Philippe, Hoang, Van Thuan, Meddeb, Line, Mailhe, Morgane, Doudier, Barbara, Courjon, Johan, Giordanengo, Valérie, Vieira, Vera Esteves, Tissot Dupont, Hervé, Honoré, Stéphane, Colson, Philippe, Chabrière, Eric, La Scola, Bernard, Rolain, Jean-Marc, Brouqui, Philippe, Raoult, Didier

“…Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the…”
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges by Lai, Chih-Cheng, Shih, Tzu-Ping, Ko, Wen-Chien, Tang, Hung-Jen, Hsueh, Po-Ren

“…•Emergence of 2019 novel coronavirus (2019-nCoV) in China has caused a large global outbreak and major public health issue.•At 9 February 2020, data from the…”
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Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality by Zhang, Chi, Wu, Zhao, Li, Jia-Wen, Zhao, Hong, Wang, Gui-Qiang

“…•Pathogenesis of cytokine release syndrome (CRS) in severe COVID-19 patients.•Key role of interleukin-6 (IL-6) in CRS.•IL-6 receptor (IL-6R) antagonist…”
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Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence by Wang, Lisheng, Wang, Yiru, Ye, Dawei, Liu, Qingquan

“…•COVID-19 is spreading fast with an increasing number of infected patients worldwide.•This review summarizes the epidemiology, clinical characteristics,…”
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New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? by Devaux, Christian A., Rolain, Jean-Marc, Colson, Philippe, Raoult, Didier

“…Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic…”
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Coronavirus disease 2019 (COVID-19): current status and future perspectives by Li, Heng, Liu, Shang-Ming, Yu, Xiao-Hua, Tang, Shi-Lin, Tang, Chao-Ke

“…•As of 3 March 2020, COVID-19 has spread rapidly in 46 countries, causing >90 000 confirmed cases and >2946 deaths.•Detection methods for SARS-CoV-2 include…”
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Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 by Colson, Philippe, Rolain, Jean-Marc, Lagier, Jean-Christophe, Brouqui, Philippe, Raoult, Didier

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The epidemiology, diagnosis and treatment of COVID-19 by Zhai, Pan, Ding, Yanbing, Wu, Xia, Long, Junke, Zhong, Yanjun, Li, Yiming

“…•The mean incubation period is 2-14 days, and the basic reproduction number is 2.24-3.58.•COVID-19 infection should be diagnosed clinically with typical…”
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategies by Sharma, Atul, Tiwari, Swapnil, Deb, Manas Kanti, Marty, Jean Louis

“…•The severe acute respiratory syndrome coronavirus-2 pandemic has led to an urgent need to assess its epidemiology•The global spread of virus is due to…”
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Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection by Fantini, Jacques, Di Scala, Coralie, Chahinian, Henri, Yahi, Nouara

“…•The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency.•Promising results suggest that chloroquine could stop the spread of…”
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Increased antimicrobial resistance during the COVID-19 pandemic by Lai, Chih-Cheng, Chen, Shey-Ying, Ko, Wen-Chien, Hsueh, Po-Ren

“…•Besides SARS-CoV-2 infection itself, increased antimicrobial resistance poses collateral damage in the COVID-19 pandemic.•There has been a rapid increase in…”
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Chloroquine for the 2019 novel coronavirus SARS-CoV-2 by Colson, Philippe, Rolain, Jean-Marc, Raoult, Didier

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Global epidemiology of coronavirus disease 2019 (COVID-19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status by Lai, Chih-Cheng, Wang, Cheng-Yi, Wang, Ya-Hui, Hsueh, Shun-Chung, Ko, Wen-Chien, Hsueh, Po-Ren

“…•As of 29 Feb. 2020, COVID-19 has affected 85 403 patients in 57 countries/territories and caused 2924 deaths in 9 countries.•The incidence (per 1 000 000…”
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Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking by Yu, Ran, Chen, Liang, Lan, Rong, Shen, Rong, Li, Peng

“…•Luteolin and chloroquine bind to the main protease of SARS-CoV-2•The binding sites of luteolin are highly consistent with the main protease…”
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Extra-respiratory manifestations of COVID-19 by Lai, Chih-Cheng, Ko, Wen-Chien, Lee, Ping-Ing, Jean, Shio-Shin, Hsueh, Po-Ren

“…•Most COVID-19 patients show fever and respiratory symptoms, however they may present extra-respiratory manifestations.•Cardiac, gastrointestinal, hepatic,…”
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Arguments in favour of remdesivir for treating SARS-CoV-2 infections by Ko, Wen-Chien, Rolain, Jean-Marc, Lee, Nan-Yao, Chen, Po-Lin, Huang, Ching-Tai, Lee, Ping-Ing, Hsueh, Po-Ren

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Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein by Vankadari, Naveen

“…•The SARS-CoV-2 pandemic is a global emergency, and new therapeutics are needed.•Molecular dynamics and structure-guided drug-binding analysis suggest that…”
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Antibacterial and antifungal properties of resveratrol by Vestergaard, Martin, Ingmer, Hanne

“…•Resveratrol has inhibitory activity against a range of bacterial pathogens.•Resveratrol affects the activity of conventional antibiotics.•Resveratrol has…”
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Procalcitonin levels in COVID-19 patients by Hu, Rui, Han, Chaofei, Pei, Shiyao, Yin, Mingzhu, Chen, Xiang

“…•Procalcitonin (PCT) levels correlate with disease severity in COVID-19 patients.•Serial PCT measurement may help to predict the prognosis of COVID-19…”
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Pseudomonas aeruginosa epidemic high-risk clones and their association with horizontally-acquired β-lactamases: 2020 update by del Barrio-Tofiño, Ester, López-Causapé, Carla, Oliver, Antonio

“…•Pseudomonas aeruginosa global clones associated with MDR/XDR phenotypes are denoted high-risk clones.•High-risk clones are a growing threat in hospitals…”
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