Search Results - "International immunopharmacology"

The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients by Yang, Ai-Ping, Liu, Jian-ping, Tao, Wen-qiang, Li, Hui-ming

“…•The COVID-19 emerged in Wuhan City and rapidly spread throughout China.•NLR exhibited the largest area under the curve, with the highest specificity and…”
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MCP-1: Function, regulation, and involvement in disease by Singh, Sanjiv, Anshita, D., Ravichandiran, V.

“…•MCP-1 inculpated in the pathogenesis of numerous diseases either directly or indirectly.•Elevated level of MCP-1 has been observed in COVID-19 patients…”
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The role of JAK/STAT signaling pathway and its inhibitors in diseases by Xin, Ping, Xu, Xiaoyun, Deng, Chengjie, Liu, Shuang, Wang, Youzhi, Zhou, Xuegang, Ma, Hongxing, Wei, Donghua, Sun, Shiqin

“…[Display omitted] •The manuscript mainly writes the structure of JAKs and STATs.•The regulation mechanism and negative regulators of JAK/STAT signaling…”
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Breast cancer: Biology, biomarkers, and treatments by Barzaman, Khadijeh, Karami, Jafar, Zarei, Zeinab, Hosseinzadeh, Aysooda, Kazemi, Mohammad Hossein, Moradi-Kalbolandi, Shima, Safari, Elahe, Farahmand, Leila

“…•BCSCs are the most critical cells leading to chemo and radio-resistance in tumor therapy.•Signaling pathways/metabolic components in BCSC could be targeted as…”
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Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors by Hargadon, Kristian M., Johnson, Coleman E., Williams, Corey J.

“…Although T lymphocytes have long been appreciated for their role in the immunosurveillance of cancer, it has been the realization that cancer cells may…”
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COVID-19 vaccine hesitancy and related fears and anxiety by Bendau, Antonia, Plag, Jens, Petzold, Moritz Bruno, Ströhle, Andreas

“…•COVID-19-related anxiety was positively associated with vaccine acceptance.•Health-related fears correlated positively with vaccine acceptance.•Social and…”
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Toll-like receptors in immunity and inflammatory diseases: Past, present, and future by Vijay, Kumar

“…The immune system is a very diverse system of the host that evolved during evolution to cope with various pathogens present in the vicinity of environmental…”
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Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway by Tang, Jia, Xu, Lingqi, Zeng, Yiwen, Gong, Fang

“…Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung…”
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Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes by Arabpour, Maedeh, Saghazadeh, Amene, Rezaei, Nima

“…•The alternatively activated macrophages secrete immunomodulatory mediators involved in tissue repair and regeneration and regulate the immune response in many…”
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The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease by Wang, Shuo, Yuan, Yu-He, Chen, Nai-Hong, Wang, Hong-Bo

“…Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological feature of which is the death of dopamine neurons in the substantia nigra…”
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Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients by Valizadeh, Hamed, Abdolmohammadi-vahid, Samaneh, Danshina, Svetlana, Ziya Gencer, Mehmet, Ammari, Ali, Sadeghi, Armin, Roshangar, Leila, Aslani, Saeed, Esmaeilzadeh, Abdolreza, Ghaebi, Mahnaz, Valizadeh, Sepehr, Ahmadi, Majid

“…As an ongoing worldwide health issue, Coronavirus disease 2019 (COVID–19) has been causing serious complications, including pneumonia, acute respiratory…”
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Effects of immune cells and cytokines on inflammation and immunosuppression in the tumor microenvironment by Li, Lihong, Yu, Rui, Cai, Tiange, Chen, Zhen, Lan, Meng, Zou, Tengteng, Wang, Bingyue, Wang, Qi, Zhao, Yiye, Cai, Yu

“…[Display omitted] Chronic inflammation and immune responses are two core element that characterize the tumor microenvironment. A large number of…”
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M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds by Wang, Youhan, Smith, Wanli, Hao, Dingjun, He, Baorong, Kong, Lingbo

“…Macrophages, as crucial cellular components of innate immunity, are characterized by possessing high plasticity and an abnormal ability to differentiate in…”
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Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets by Kumar, V.

“…[Display omitted] •Sepsis infects more than 48.9 million people world-wide, with 19.7 million deaths.•Cytokine storm plays a significant role in sepsis, along…”
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THP-1 cell line: An in vitro cell model for immune modulation approach by Chanput, Wasaporn, Mes, Jurriaan J., Wichers, Harry J.

“…THP-1 is a human leukemia monocytic cell line, which has been extensively used to study monocyte/macrophage functions, mechanisms, signaling pathways, and…”
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Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality by Al-Kuraishy, Hayder M., Al-Gareeb, Ali I., Al-hussaniy, Hany Akeel, Al-Harcan, Nasser A. Hadi, Alexiou, Athanasios, Batiha, Gaber El-Saber

“…•In severe SARS-CoV-2 infection, there are solid inflammatory reactions due to neutrophil recruitments and formation of NETs.•Sustained formations of NETs…”
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Role of pyroptosis in cardiovascular diseases by Jia, Chang, Chen, Huanwen, Zhang, Jian, Zhou, Kailiang, Zhuge, Yingzhi, Niu, Chao, Qiu, Jianxin, Rong, Xing, Shi, Zhewei, Xiao, Jian, Shi, Yong, Chu, Maoping

“…Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically unique form of programmed cell death compared to others, such as…”
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CTLA-4: From mechanism to autoimmune therapy by Hosseini, Arezoo, Gharibi, Tohid, Marofi, Faroogh, Babaloo, Zohreh, Baradaran, Behzad

“…•We present recent advances in CTLA-4 in regulating T-cell tolerance and autoimmunity.•The structure and expression of CTLA-4, its mediated signaling and role…”
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Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia by Li, Zijian, Liu, Fei, He, Xin, Yang, Xue, Shan, Fengping, Feng, Juan

“…Multiple sclerosis (MS) is a chronic demyelinating disease caused by central nervous system (CNS) inflammation and immune dysfunction, which often leaves…”
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Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB signal pathway by Yan, Nao, Xu, Zhipeng, Qu, Changhua, Zhang, JunJian

“…•DMF improved learning and memory decline in rats subjected to CCH.•Ferroptosis was involved in hippocampal neurons damage and loss in rats subjected to…”
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