Search Results - "Intano, Gabriel W."

Mutation Frequency Declines during Spermatogenesis in Young Mice but Increases in Old Mice by Walter, Christi A., Intano, Gabriel W., McCarrey, John R., McMahan, C. Alex, Walter, Ronald B.

“…Five percent of live-born human offspring will have a genetic disorder. Of these, 20% are because of germ-line de novo mutations. Several genetic diseases,…”
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Base Excision Repair Is Limited by Different Proteins in Male Germ Cell Nuclear Extracts Prepared from Young and Old Mice by Intano, Gabriel W., McMahan, C. Alex, McCarrey, John R., Walter, Ronald B., McKenna, Allison E., Matsumoto, Yoshihiro, MacInnes, Mark A., Chen, David J., Walter, Christi A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Absence of global genomic cytosine methylation pattern erasure during medaka ( Oryzias latipes) early embryo development by Walter, Ronald B., Li, Hai-Ying, Intano, Gabriel W., Kazianis, Steven, Walter, Christi A.

“…Two techniques were used to analyze global genomic 5-methyl cytosine methylation at CCGG sites of medaka embryo DNA. DNA was labeled by incorporation of…”
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Age-related Base Excision Repair Activity in Mouse Brain and Liver Nuclear Extracts by Intano, Gabriel W., Cho, Eun Ju, McMahan, C. Alex, Walter, Christi A.

“…To assess DNA repair activity relative to age, in vitro base excision repair assays were performed using brain and liver nuclear extracts prepared from mice of…”
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Spontaneous Hepatocellular Carcinoma is Reduced in Transgenic Mice Overexpressing Human O6-Methylguanine-DNA Methyltransferase by Zhou, Zi-Qiang, Manguino, Diwi, Kewitt, Kristen, Intano, Gabriel W., McMahan, C. Alex, Herbert, Damon C., Hanes, Martha, Reddick, Robert, Ikeno, Yuji, Walter, Christi A.

“…O6-methylguanine (O6mG) is a potent mutagenic and procarcinogenic DNA lesion. Organisms have evolved with a DNA repair mechanism that largely ameliorates the…”
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Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis by Xu, Guogang, Intano, Gabriel W., McCarrey, John R., Walter, Ronald B., Alex McMahan, C., Walter, Christi A.

“…Humans are exposed to ionizing radiation (IR) under various circumstances, e.g. cosmic radiation, diagnostic X-rays and radiotherapy for cancer. It has been…”
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Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity by Intano, G W, McMahan, C A, Walter, R B, McCarrey, J R, Walter, C A

“…Spermatogenic cells exhibit a lower spontaneous mutation frequency than somatic tissues in a lacI transgene and many base excision repair (BER) genes display…”
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Mutation spectral changes in spermatogenic cells obtained from old mice by Walter, Christi A, Intano, Gabriel W, McMahan, C.Alex, Kelner, Kevin, McCarrey, John R, Walter, Ronald B

“…Male reproductive health is compromised with increased paternal age, due at least in part, to an increased frequency of de novo germline mutations. Because of…”
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Relative base excision repair in Xiphophorus fish tissue extracts by Walter, R B, Sung, H M, Obermoeller, R D, Mitchell, D L, Intano, G W, Walter, C A

“…To begin characterizing DNA repair capability among Xiphophorus species, we adapted oligonucleotide-based DNA repair assays to extracts of fish tissues. Here,…”
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Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O 6 - methylguanine-DNA methyltransferase by Zhou, Zi-Qiang, Manguino, Diwi, Kewitt, Kristen, Intano, Gabriel W., McMahan, C. Alex, Herbert, Damon C., Hanes, Martha, Reddick, Robert, Ikeno, Yuji, Walter, Christi A.

“…O 6 -methylguanine ( O 6 mG) is a potent mutagenic and procarcinogenic DNA lesion. Organisms have evolved with a DNA repair mechanism that largely ameliorates…”
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Mutagenesis and DNA Base Excision Repair in Germ Cells of Young and Old Male Mice by Intano, Gabriel W, McMahan, C Alex, Walter, Christi A

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