Search Results - "Insko, E."

A small molecule-kinase interaction map for clinical kinase inhibitors by Zarrinkar, Patrick P, Floyd, Mark, Lai, Andiliy G, Atteridge, Corey E, Carter, Todd A, Galvin, Margaret, Mehta, Shamal A, Lélias, Jean-Michel, Wodicka, Lisa M, Benedetti, Michael G, Azimioara, Mihai D, Treiber, Daniel K, Insko, Darren E, Insko, Michael A, Edeen, Philip T, Gerlach, Jay L, Fabian, Miles A, Grotzfeld, Robert M, Lockhart, David J, Patel, Hitesh K, Milanov, Zdravko V, Ciceri, Pietro, Biggs, William H, Herrgard, Sanna, Velasco, Anne Marie, Ford, Julia M

“…Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase inhibitor specificity by measuring…”
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Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E by Rowbottom, Martin W, Faraoni, Raffaella, Chao, Qi, Campbell, Brian T, Lai, Andiliy G, Setti, Eduardo, Ezawa, Maiko, Sprankle, Kelly G, Abraham, Sunny, Tran, Lan, Struss, Brian, Gibney, Michael, Armstrong, Robert C, Gunawardane, Ruwanthi N, Nepomuceno, Ronald R, Valenta, Ianina, Hua, Helen, Gardner, Michael F, Cramer, Merryl D, Gitnick, Dana, Insko, Darren E, Apuy, Julius L, Jones-Bolin, Susan, Ghose, Arup K, Herbertz, Torsten, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce, Williams, Michael, Bhagwat, Shripad, James, Joyce, Holladay, Mark W

“…The Ras/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway plays a central role in the regulation of cell growth, differentiation, and…”
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Inhibition of Drug-Resistant Mutants of ABL, KIT, and EGF Receptor Kinases by Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., Milanov, Zdravko V., Atteridge, Corey E., Biggs, William H., Edeen, Philip T., Floyd, Mark, Ford, Julia M., Grotzfeld, Robert M., Herrgard, Sanna, Insko, Darren E., Mehta, Shamal A., Patel, Hitesh K., Pao, William, Sawyers, Charles L., Varmus, Harold, Zarrinkar, Patrick P., Lockhart, David J.

“…To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the emergence of drug resistance in…”
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Sodium MRI of human articular cartilage in vivo by Reddy, R, Insko, E K, Noyszewski, E A, Dandora, R, Kneeland, J B, Leigh, J S

“…Preliminary results from in vivo sodium MRI of human patellar articular cartilage are presented. Sodium images generated of an in vitro bovine patella clearly…”
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Quantitative Magnetic Resonance Imaging of Human Brain Perfusion at 1.5 T Using Steady-State Inversion of Arterial Water by Robert, David A., Detre, John A., Bolinger, Lizann, Insko, Erik K., Leigh, John S.

“…We report our experience using a noninvasive magnetic resonance technique for quantitative imaging of human brain perfusion at 1.5 T. This technique uses…”
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Sodium NMR evaluation of articular cartilage degradation by Insko, Erik K., Kaufman, Jonathan H., Leigh, John S., Reddy, Ravinder

“…One of the first effects of degenerative osteoarthritis is the loss of proteoglycans from the matrix of articular cartilage. Using a model of osteoarthritic…”
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Renal perfusion in humans: MR imaging with spin tagging of arterial water by Roberts, D A, Detre, J A, Bolinger, L, Insko, E K, Lenkinski, R E, Pentecost, M J, Leigh, Jr, J S

“…The authors tested a noninvasive technique for magnetic resonance imaging of perfusion in human kidneys. Magnetic labeling (spin tagging) of aortic arterial…”
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Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors by Liu, Gang, Abraham, Sunny, Liu, Xing, Xu, Shimin, Rooks, Allison M., Nepomuceno, Ron, Dao, Alan, Brigham, Daniel, Gitnick, Dana, Insko, Darren E., Gardner, Michael F., Zarrinkar, Patrick P., Christopher, Ron, Belli, Barbara, Armstrong, Robert C., Holladay, Mark W.

“…[Display omitted] Based on a putative binding mode of quizartinib (AC220, 1), a potent FMS-like tyrosine kinase 3 (FLT3) inhibitor in Phase III clinical…”
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Antiphospholipid syndrome: patterns of life-threatening and severe recurrent vascular complications by Insko, E K, Haskal, Z J

“…To demonstrate the variety and recurrence patterns of severe arterial and venous thromboembolic events that occur in patients with the antiphospholipid…”
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CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity by James, Joyce, Ruggeri, Bruce, Armstrong, Robert C, Rowbottom, Martin W, Jones-Bolin, Susan, Gunawardane, Ruwanthi N, Dobrzanski, Pawel, Gardner, Michael F, Zhao, Hugh, Cramer, Merryl D, Hunter, Kathryn, Nepomuceno, Ronald R, Cheng, Mangeng, Gitnick, Dana, Yazdanian, Mehran, Insko, Darren E, Ator, Mark A, Apuy, Julius L, Faraoni, Raffaella, Dorsey, Bruce D, Williams, Michael, Bhagwat, Shripad S, Holladay, Mark W

“…Mutations in the BRAF gene have been identified in approximately 7% of cancers, including 60% to 70% of melanomas, 29% to 83% of papillary thyroid carcinomas,…”
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Congenital esophageal stenosis in adults by Katzka, David A, Levine, Marc S, Ginsberg, Gregory G, Hammod, Riyadh, Katz, Philip O, Insko, Erik K, Raffensperger, Edward C, Metz, David C

“…Congenital esophageal stenosis is thought to be a rare disease confined to infancy and childhood with only a few case reports in adults described. We report…”
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High resolution, short echo time sodium imaging of articular cartilage by Insko, E K, Reddy, R, Leigh, J S

“…The sodium present in articular cartilage interacts with the negatively charged proteoglycan aggregates in the matrix of the cartilage. Sodium images of short…”
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Clinical Pharmacokinetics and FLT3 Phosphorylation of AC220, a Highly Potent and Selective Inhibitor of FLT3 by James, Joyce, Pratz, Keith, Stine, Adam, Apuy, Julius L, Insko, Darren E, Armstrong, Robert C, Zarrinkar, Patrick P, Small, Donald, Wierenga, Wendell, Levis, Mark J.

“…Several different FLT3 inhibitors have now been tested as monotherapy for AML patients and have met with only limited success. To date, none of these…”
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Generalized Reciprocity by Insko, E.K., Elliott, M.A., Schotland, J.C., Leigh, J.S.

“…The remarkable theorem of reciprocity as described by D. I. Hoult and R. E. Richards (J. Magn. Reson.24, 71 (1976)) may be generalized to account for the near,…”
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Triple quantum sodium imaging of articular cartilage by Reddy, R, Insko, E K, Leigh, J S

“…Triple quantum (TQ) sodium imaging of bovine articular cartilage is presented. True triple quantum imaging sequence was modified to incorporate asymmetric echo…”
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Multicoil array for high resolution imaging of the breast by Insko, E K, Connick, T J, Schnall, M D, Orel, S G

“…An RF multicoil array for high resolution imaging of the breast is presented. The RF multicoil is incorporated into a dedicated breast imaging apparatus that…”
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Volumetric measurement of human calf muscle from magnetic resonance imaging by Elliott, M A, Walter, G A, Gulish, H, Sadi, A S, Lawson, D D, Jaffe, W, Insko, E K, Leigh, J S, Vandenborne, K

“…Muscle mass is a determining factor in skeletal muscle function and is affected by inactivity, immobilization, disease, and aging. The aim of this study was to…”
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Quantitative magnetic resonance imaging demonstrates alterations of the lingual musculature in obstructive sleep apnea by Schotland, H M, Insko, E K, Schwab, R J

“…Upper airway musculature is important in the pathogenesis of obstructive sleep apnea. Electromyographic studies of patients with obstructive sleep apnea…”
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Continuous inversion angiography by Roberts, D A, Bolinger, L, Detre, J A, Insko, E K, Bergey, P, Leigh, Jr, J S

“…A subtractive time-of-flight technique for magnetic resonance angiography is described. In this approach, the arterial supply to an organ is inverted in a…”
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Quantitative magnetic resonance imaging of upper airways musculature in an animal model of sleep apnea by Schotland, H M, Insko, E K, Panckeri, K A, Leigh, J S, Pack, A I, Hendricks, J C

“…Electromyographic studies of patients with sleep apnea and of the English bulldog, an animal model of sleep apnea, indicate that there is increase activity of…”
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