Search Results - "Inserte, Javier"

The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism by Inserte, Javier, Garcia‐Dorado, David

“…Cardiomyocyte cell death occurring during myocardial reperfusion (reperfusion injury) contributes to final infarct size after transient coronary occlusion…”
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Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction by Alonso-Herranz, Laura, Sahún-Español, Álvaro, Paredes, Ana, Gonzalo, Pilar, Gkontra, Polyxeni, Núñez, Vanessa, Clemente, Cristina, Cedenilla, Marta, Villalba-Orero, María, Inserte, Javier, García-Dorado, David, Arroyo, Alicia G, Ricote, Mercedes

“…Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these factors crosstalk with…”
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Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2 by Aluja, David, Inserte, Javier, Penela, Petronila, Ramos, Paula, Ribas, Catalina, Iñiguez, Miguel Ángel, Mayor, Federico, Garcia-Dorado, David

“…Inhibition of the Ca 2+ -dependent proteases calpains attenuates post-infarction remodeling and heart failure. Recent data suggest that calpain activity is…”
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Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy by Aluja, David, Delgado-Tomás, Sara, Ruiz-Meana, Marisol, Barrabés, José A, Inserte, Javier

“…Despite advances in its treatment, heart failure remains a major cause of morbidity and mortality, evidencing an urgent need for novel mechanism-based targets…”
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Role of the parasympathetic nervous system in cardioprotection by remote hindlimb ischaemic preconditioning by Donato, Martín, Buchholz, Bruno, Rodríguez, Manuel, Pérez, Virginia, Inserte, Javier, García‐Dorado, David, Gelpi, Ricardo J.

“…New findings •  What is the central question of this study? Ischaemia–reperfusion of peripheral tissues protects the heart from subsequent myocardial…”
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Long-Term Protective Effects of Succinate Dehydrogenase Inhibition during Reperfusion with Malonate on Post-Infarction Left Ventricular Scar and Remodeling in Mice by Valls-Lacalle, Laura, Consegal, Marta, Ganse, Freddy G, Yáñez-Bisbe, Laia, Pastor, Javier, Ruiz-Meana, Marisol, Inserte, Javier, Benito, Begoña, Ferreira-González, Ignacio, Rodríguez-Sinovas, Antonio

“…Succinate dehydrogenase inhibition with malonate during initial reperfusion reduces myocardial infarct size in both isolated mouse hearts subjected to global…”
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Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy by Yáñez-Bisbe, Laia, Garcia-Elias, Anna, Tajes, Marta, Almendros, Isaac, Rodríguez-Sinovas, Antonio, Inserte, Javier, Ruiz-Meana, Marisol, Farré, Ramón, Farré, Núria, Benito, Begoña

“…Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We…”
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Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning by Consegal, Marta, Núñez, Norberto, Barba, Ignasi, Benito, Begoña, Ruiz-Meana, Marisol, Inserte, Javier, Ferreira-González, Ignacio, Rodríguez-Sinovas, Antonio

“…Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate,…”
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TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6 by Yáñez-Bisbe, Laia, Moya, Mar, Rodríguez-Sinovas, Antonio, Ruiz-Meana, Marisol, Inserte, Javier, Tajes, Marta, Batlle, Montserrat, Guasch, Eduard, Mas-Stachurska, Aleksandra, Miró, Elisabet, Rivas, Nuria, Ferreira González, Ignacio, Garcia-Elias, Anna, Benito, Begoña

“…TRPV4 channels, which respond to mechanical activation by permeating Ca into the cell, may play a pivotal role in cardiac remodeling during cardiac overload…”
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Effect of COMBinAtion therapy with remote ischemic conditioning and exenatide on the Myocardial Infarct size: a two-by-two factorial randomized trial (COMBAT-MI) by García del Blanco, Bruno, Otaegui, Imanol, Rodríguez-Palomares, José F., Bayés-Genis, Antoni, Fernández-Nofrerías, Eduard, Vilalta del Olmo, Victoria, Carrillo, Xavier, Ibáñez, Borja, Worner, Fernando, Casanova, Juan, Pueo, Eva, González-Juanatey, Jose R., López-Pais, Javier, Bardají, Alfredo, Bonet, Gil, Fuertes, Mónica, Rodríguez-Sinovas, Antonio, Ruiz-Meana, Marisol, Inserte, Javier, Barba, Ignasi, Gómez-Talavera, Sandra, Martí, Gerard, Serra, Bernat, Bellera, Neus, Ojeda-Ramos, Manuel, Cuellar, Hug, Valente, Filipa, Carmona, Maria Ángeles, Miró-Casas, Elisabet, Marsal, Josep R., Sambola, Antonia, Lidón, Rosa M., Bañeras, Jordi, Elízaga, Jaime, Padilla, Ferran, Barrabés, José A., Hausenloy, Derek J., Ferreira-González, Ignacio, García-Dorado, David

“…Remote ischemic conditioning (RIC) and the GLP-1 analog exenatide activate different cardioprotective pathways and may have additive effects on infarct size…”
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Altered FoF1 ATP synthase and susceptibility to mitochondrial permeability transition pore during ischaemia and reperfusion in aging cardiomyocytes by Fernandez-Sanz, Celia, Ruiz-Meana, Marisol, Castellano, José, Miro-Casas, Elisabet, Nuñez, Estefanía, Inserte, Javier, Vázquez, Jesús, Garcia-Dorado, David

“…Aging is a major determinant of the incidence and severity of ischaemic heart disease. Preclinical information suggests the existence of intrinsic cellular…”
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Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart by Cardona, Maria, López, Juan Antonio, Serafín, Anna, Rongvaux, Anthony, Inserte, Javier, García-Dorado, David, Flavell, Richard, Llovera, Marta, Cañas, Xavier, Vázquez, Jesús, Sanchis, Daniel

“…Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during…”
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Ischemic preconditioning protects cardiomyocyte mitochondria through mechanisms independent of cytosol by Ruiz-Meana, Marisol, Núñez, Estefanía, Miro-Casas, Elisabet, Martínez-Acedo, Pablo, Barba, Ignasi, Rodriguez-Sinovas, Antonio, Inserte, Javier, Fernandez-Sanz, Celia, Hernando, Victor, Vázquez, Jesús, Garcia-Dorado, David

“…Abstract Mitochondria play a central role in the protection conferred by ischemic preconditioning (IP) by not fully elucidated mechanisms. We investigated…”
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Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk by Consegal, Marta, Barba, Ignasi, García del Blanco, Bruno, Otaegui, Imanol, Rodríguez-Palomares, José F., Martí, Gerard, Serra, Bernat, Bellera, Neus, Ojeda-Ramos, Manuel, Valente, Filipa, Carmona, Maria Ángeles, Miró-Casas, Elisabet, Sambola, Antonia, Lidón, Rosa María, Bañeras, Jordi, Barrabés, José Antonio, Rodríguez, Cristina, Benito, Begoña, Ruiz-Meana, Marisol, Inserte, Javier, Ferreira-González, Ignacio, Rodríguez-Sinovas, Antonio

“…Succinate is enhanced during initial reperfusion in blood from the coronary sinus in ST-segment elevation myocardial infarction (STEMI) patients and in pigs…”
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Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion by Hernando, Víctor, Inserte, Javier, Sartório, Carmem Luíza, Parra, Víctor M, Poncelas-Nozal, Marcos, Garcia-Dorado, David

“…Abstract Calpains contribute to reperfusion-induced myocardial cell death. However, it remains controversial whether its activation occurs during ischemia or…”
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Contribution of delayed intracellular pH recovery to ischemic postconditioning protection by Inserte, Javier, Ruiz-Meana, Marisol, Rodríguez-Sinovas, Antonio, Barba, Ignasi, Garcia-Dorado, David

“…Ischemic postconditioning (PoCo) has been proven to be a feasible approach to attenuate reperfusion injury and enhance myocardial salvage in patients with…”
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Connexin 43 Deficiency Is Associated with Reduced Myocardial Scar Size and Attenuated TGFβ1 Signaling after Transient Coronary Occlusion in Conditional Knock-Out Mice by Valls-Lacalle, Laura, Consegal, Marta, Ruiz-Meana, Marisol, Benito, Begoña, Inserte, Javier, Barba, Ignasi, Ferreira-González, Ignacio, Rodríguez-Sinovas, Antonio

“…Previous studies demonstrated a reduction in myocardial scar size in heterozygous Cx43 mice subjected to permanent coronary occlusion. However, patients…”
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The role of mitochondrial permeability transition in reperfusion-induced cardiomyocyte death depends on the duration of ischemia by Ruiz-Meana, Marisol, Inserte, Javier, Fernandez-Sanz, Celia, Hernando, Victor, Miro-Casas, Elisabet, Barba, Ignasi, Garcia-Dorado, David

“…Mitochondrial permeability transition (MPT) is critical in cardiomyocyte death during reperfusion but it is not the only mechanism responsible for cell injury…”
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Efficacy of a cysteine protease inhibitor compared with enalapril in murine heart failure models by Aluja, David, Delgado-Tomás, Sara, Barrabés, Jose A., Miró-Casas, Elisabet, Ruiz-Meana, Marisol, Rodríguez-Sinovas, Antonio, Benito, Begoña, Wang, Jinxi, Song, Long-Sheng, Ferreira-González, Ignacio, Inserte, Javier

“…Cysteine proteases calpains contribute to heart failure (HF), but it remains unknown whether their inhibition provides any benefit compared to standard…”
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Activation of cGMP/Protein Kinase G Pathway in Postconditioned Myocardium Depends on Reduced Oxidative Stress and Preserved Endothelial Nitric Oxide Synthase Coupling by Inserte, Javier, Hernando, Victor, Vilardosa, Úrsula, Abad, Elena, Poncelas‐Nozal, Marcos, Garcia‐Dorado, David

“…Background The cGMP/protein kinase G (PKG) pathway is involved in the cardioprotective effects of postconditioning (PoCo). Although PKG signaling in PoCo has…”
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