Search Results - "Insel, Philip"

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease by Ossenkoppele, Rik, Smith, Ruben, Ohlsson, Tomas, Strandberg, Olof, Mattsson, Niklas, Insel, Philip S, Palmqvist, Sebastian, Hansson, Oskar

“…OBJECTIVETo examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the…”
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Association Between Apolipoprotein E ε2 vs ε4, Age, and β-Amyloid in Adults Without Cognitive Impairment by Insel, Philip S, Hansson, Oskar, Mattsson-Carlgren, Niklas

“…Although the most common recent approach in Alzheimer disease drug discovery is to directly target the β-amyloid (Aβ) pathway, the high prevalence of…”
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Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease by Palmqvist, Sebastian, Insel, Philip S, Stomrud, Erik, Janelidze, Shorena, Zetterberg, Henrik, Brix, Britta, Eichenlaub, Udo, Dage, Jeffrey L, Chai, Xiyun, Blennow, Kaj, Mattsson, Niklas, Hansson, Oskar

“…Failures in Alzheimer's disease (AD) drug trials highlight the need to further explore disease mechanisms and alterations of biomarkers during the development…”
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Genetic Moderation of the Association of β-Amyloid With Cognition and MRI Brain Structure in Alzheimer Disease by Insel, Philip S, Kumar, Atul, Hansson, Oskar, Mattsson-Carlgren, Niklas

“…There is considerable heterogeneity in the association between increasing β-amyloid (Aβ) pathology and early cognitive dysfunction in preclinical Alzheimer…”
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(18)F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease by Mattsson, Niklas, Schöll, Michael, Strandberg, Olof, Smith, Ruben, Palmqvist, Sebastian, Insel, Philip S, Hägerström, Douglas, Ohlsson, Tomas, Zetterberg, Henrik, Jögi, Jonas, Blennow, Kaj, Hansson, Oskar

“…To elucidate the relationship between cerebrospinal fluid (CSF) total-tau (T-tau) and phosphorylated tau (P-tau) with the tau PET ligand (18)F-AV-1451 in…”
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Plasma tau in Alzheimer disease by Mattsson, Niklas, Zetterberg, Henrik, Janelidze, Shorena, Insel, Philip S, Andreasson, Ulf, Stomrud, Erik, Palmqvist, Sebastian, Baker, David, Tan Hehir, Cristina A, Jeromin, Andreas, Hanlon, David, Song, Linan, Shaw, Leslie M, Trojanowski, John Q, Weiner, Michael W, Hansson, Oskar, Blennow, Kaj

“…OBJECTIVE:To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology…”
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Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease by EWERS, Michael, INSEL, Philip S, STERN, Yaakov, WEINER, Michael W

“…To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metabolism in elderly cognitively healthy (HC) subjects with…”
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Comparing 18 F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease by Mattsson, Niklas, Smith, Ruben, Strandberg, Olof, Palmqvist, Sebastian, Schöll, Michael, Insel, Philip S, Hägerström, Douglas, Ohlsson, Tomas, Zetterberg, Henrik, Blennow, Kaj, Jögi, Jonas, Hansson, Oskar

“…To compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for…”
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Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest by Moseby-Knappe, Marion, Mattsson, Niklas, Nielsen, Niklas, Zetterberg, Henrik, Blennow, Kaj, Dankiewicz, Josef, Dragancea, Irina, Friberg, Hans, Lilja, Gisela, Insel, Philip S, Rylander, Christian, Westhall, Erik, Kjaergaard, Jesper, Wise, Matt P, Hassager, Christian, Kuiper, Michael A, Stammet, Pascal, Wanscher, Michael C Jaeger, Wetterslev, Jørn, Erlinge, David, Horn, Janneke, Pellis, Tommaso, Cronberg, Tobias

“…Prognostication of neurologic outcome after cardiac arrest is an important but challenging aspect of patient therapy management in critical care units. To…”
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18F‐AV‐1451 and CSF T‐tau and P‐tau as biomarkers in Alzheimer's disease by Mattsson, Niklas, Schöll, Michael, Strandberg, Olof, Smith, Ruben, Palmqvist, Sebastian, Insel, Philip S, Hägerström, Douglas, Ohlsson, Tomas, Zetterberg, Henrik, Jögi, Jonas, Blennow, Kaj, Hansson, Oskar

“…To elucidate the relationship between cerebrospinal fluid (CSF) total‐tau (T‐tau) and phosphorylated tau (P‐tau) with the tau PET ligand 18 F‐AV‐1451 in…”
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Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease by Mattsson, Niklas, Insel, Philip S, Donohue, Michael, Landau, Susan, Jagust, William J, Shaw, Leslie M, Trojanowski, John Q, Zetterberg, Henrik, Blennow, Kaj, Weiner, Michael W

“…Reduced cerebrospinal fluid amyloid-β42 and increased retention of florbetapir positron emission tomography are biomarkers reflecting cortical amyloid load in…”
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Time between milestone events in the Alzheimer's disease amyloid cascade by Insel, Philip S., Donohue, Michael C., Berron, David, Hansson, Oskar, Mattsson-Carlgren, Niklas

“…•The time-from-Aβ pathology measure identifies early signs of disease progression.•Increases in tau pathology and cognitive dysfunction occur 4–8 years prior…”
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Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease by Mattsson, Niklas, Insel, Philip S., Donohue, Michael, Jögi, Jonas, Ossenkoppele, Rik, Olsson, Tomas, Schöll, Michael, Smith, Ruben, Hansson, Oskar

“…The relative importance of structural magnetic resonance imaging (MRI) and tau positron emission tomography (PET) to predict diagnosis and cognition in…”
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Serum tau and neurological outcome in cardiac arrest by Mattsson, Niklas, Zetterberg, Henrik, Nielsen, Niklas, Blennow, Kaj, Dankiewicz, Josef, Friberg, Hans, Lilja, Gisela, Insel, Philip S., Rylander, Christian, Stammet, Pascal, Aneman, Anders, Hassager, Christian, Kjaergaard, Jesper, Kuiper, Michael, Pellis, Tommaso, Wetterslev, Jørn, Wise, Matthew, Cronberg, Tobias

“…Objective To test serum tau as a predictor of neurological outcome after cardiac arrest. Methods We measured the neuronal protein tau in serum at 24, 48, and…”
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Determining clinically meaningful decline in preclinical Alzheimer disease by Insel, Philip S, Weiner, Michael, Mackin, R Scott, Mormino, Elizabeth, Lim, Yen Ying, Stomrud, Erik, Palmqvist, Sebastian, Masters, Colin L, Maruff, Paul T, Hansson, Oskar, Mattsson, Niklas

“…OBJECTIVETo determine the time required for a preclinical Alzheimer disease population to decline in a meaningful way, use estimates of decline to update…”
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Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease by Mattsson, Niklas, Smith, Ruben, Strandberg, Olof, Palmqvist, Sebastian, Schöll, Michael, Insel, Philip S, Hägerström, Douglas, Ohlsson, Tomas, Zetterberg, Henrik, Blennow, Kaj, Jögi, Jonas, Hansson, Oskar

“…OBJECTIVETo compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance…”
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Early stages of tau pathology and its associations with functional connectivity, atrophy and memory by Berron, David, Vogel, Jacob W, Insel, Philip S, Pereira, Joana B, Xie, Long, Wisse, Laura E M, Yushkevich, Paul A, Palmqvist, Sebastian, Mattsson-Carlgren, Niklas, Stomrud, Erik, Smith, Ruben, Strandberg, Olof, Hansson, Oskar

“…In Alzheimer's disease, post-mortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a…”
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Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer’s disease by Johansson, Maurits, Stomrud, Erik, Insel, Philip S., Leuzy, Antoine, Johansson, Per Mårten, Smith, Ruben, Ismail, Zahinoor, Janelidze, Shorena, Palmqvist, Sebastian, van Westen, Danielle, Mattsson-Carlgren, Niklas, Hansson, Oskar

“…Mild behavioral impairment (MBI) is suggested as risk marker for neurodegenerative diseases, such as Alzheimer’s disease (AD). Recently, pathologic tau…”
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Reply to: Brain Amyloid Deposition in Late-Life Depression by Mackin, R. Scott, Insel, Philip S.

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Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer’s Disease Neuroimaging Initiative Depression Project by Mackin, R. Scott, Insel, Philip S., Landau, Susan, Bickford, David, Morin, Ruth, Rhodes, Emma, Tosun, Duygu, Rosen, Howie J., Butters, Meryl, Aisen, Paul, Raman, Rema, Saykin, Andrew, Toga, Arthur, Jack, Clifford, Koeppe, Robert, Weiner, Michael W., Nelson, Craig

“…We evaluated the role of cortical amyloid deposition as a factor contributing to memory dysfunction and increased risk of dementia associated with late-life…”
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