Search Results - "Insel, P. A."

Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger by Insel, P. A., Zhang, L., Murray, F., Yokouchi, H., Zambon, A. C.

“…The second messenger cyclic AMP (cAMP) can either stimulate or inhibit programmed cell death (apoptosis). Here, we review examples of cell types that show…”
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GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets? by Insel, PA, Snead, A, Murray, F, Zhang, L, Yokouchi, H, Katakia, T, Kwon, O, Dimucci, D, Wilderman, A

“…G‐protein‐coupled receptors [GPCRs, also known as 7‐transmembrane (7‐TM) receptors] comprise the largest family of membrane receptors in humans and other…”
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G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains by Patel, H H, Murray, F, Insel, P A

“…The efficiency of signal transduction in cells derives in part from subcellular, in particular plasma membrane, microdomains that organize signaling molecules…”
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Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications by Rana, B K, Shiina, T, Insel, P A

“…G protein-coupled receptors (GPCRs) represent a major class of proteins in the genome of many species, including humans. In addition to the mapping of a number…”
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Distribution analysis of nonsynonymous polymorphisms within the G-protein-coupled receptor gene family by Lee, Andria, Rana, B.K., Schiffer, H.H., Schork, N.J., Brann, M.R., Insel, P.A., Weiner, D.M.

“…The G-protein-coupled receptor (GPCR) superfamily is one of the largest classes of proteins in mammalian genomes. GPCRs mediate diverse physiological functions…”
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Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2 by BALBOA, M. A, FIRESTEIN, B. L, GODSON, C, BELL, K. S, INSEL, P. A

“…Protein kinase C (PKC) has been implicated in the activation of phospholipase D (PLD) in a number of systems. By antisense technology, we have "knocked out"…”
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Retrovirally mediated transfer of a G protein-coupled receptor kinase (GRK) dominant-negative mutant enhances endogenous calcitonin receptor signaling in Chinese hamster ovary cells. GRK inhibition enhances expression of receptors and receptor mRNA by Horie, K, Insel, P A

“…G protein-coupled receptor kinases (GRKs) initiate pathways leading to agonist-dependent phosphorylation and desensitization of G protein-coupled receptors…”
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Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells by Insel, P A, Wilderman, A, Zhang, L, Keshwani, M M, Zambon, A C

“…Increases in cyclic AMP (cAMP) are pro-apoptotic in numerous cell types, but the mechanisms of cAMP-promoted apoptosis are poorly defined. We have used murine…”
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Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells. Evidence that bradykinin mediates noninterdependent activation of phospholipases A2 and C by Slivka, S R, Insel, P A

“…Many types of peptide hormone and neurotransmitter receptors mediate hydrolysis of phosphoinositides (PI) and arachidonic acid and arachidonic acid metabolite…”
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Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes by Post, S R, Hilal-Dandan, R, Urasawa, K, Brunton, L L, Insel, P A

“…We have investigated the stoichiometric relationship of proteins involved in beta-adrenergic-receptor-mediated signal transduction in isolated rat cardiac…”
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Do studies in caveolin‐knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for ‘lost proteins’? by Insel, P A, Patel, H H

“…A wide array of phenotypic changes have been reported in mice with knockout of expression of caveolin‐1. Neidhold et al. (2007) describe results in this issue…”
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Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells by Firestein, B L, Xing, M, Hughes, R J, Corvera, C U, Insel, P A

“…We have characterized the signaling pathways of purinergic receptors present on the renal epithelial cell line, Madin-Darby canine kidney (MDCK, D1 subclone)…”
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Stimulation of β -adrenergic Receptors of S49 Lymphoma Cells Redistributes the α Subunit of the Stimulatory G Protein between Cytosol and Membranes by Ransnäs, Lennart A., Svoboda, Petr, Jasper, Jeffrey R., Insel, Paul A.

“…The stimulatory guanine nucleotide-binding protein (Gs), which links cell-surface receptors to second-messenger effector systems, is assumed to be confined to…”
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Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2 by Slivka, S.R., Insel, P.A.

“…alpha 1-Adrenergic receptors mediate two effects on phospholipid metabolism in Madin-Darby canine kidney (MDCK-D1) cells: hydrolysis of phosphoinositides and…”
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Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP by Ostrom, R S, Gregorian, C, Drenan, R M, Gabot, K, Rana, B K, Insel, P A

“…Madin-Darby canine kidney (MDCK) cells release ATP upon mechanical or biochemical activation, initiating P2Y receptor signaling that regulates basal levels of…”
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The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells by Zhang, Lingzhi, Insel, Paul A

“…The mechanisms by which cAMP mediates apoptosis are not well understood. In the current studies, we used wild-type (WT) S49 T-lymphoma cells and the kin –…”
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Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling by Insel, Paul A, Ostrom, Rennolds S

“…1. As initially shown by Seamon and Daly, the diterpene forskolin directly activates adenylyl cyclase (AC) and raises cyclic AMP levels in a wide variety of…”
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Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells by GODSON, C, WEISS, B. A, INSEL, P. A

“…The heterogeneity of the protein kinase C (PKC) gene family strongly suggests that different isoforms may have distinct functions in mediating signal…”
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Inhibition of expression of protein kinase C alpha by antisense cDNA inhibits phorbol ester-mediated arachidonate release by GODSON, C, BELL, K. S, INSEL, P. A

“…A major unresolved issue in the area of signal transduction relates to the role of particular isoforms of protein kinase C (PKC) in mediating cellular…”
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Adrenergic control of circulating lymphocyte subpopulations: effects of congestive heart failure, dynamic exercise, and terbutaline treatment by MAISEL, A. S, KNOWLTON, K. U, FOWLER, P, REARDEN, A, ZIEGLER, M. G, MOTULSKY, H. J, INSEL, P. A, MICHEL, M. C

“…The current studies were undertaken to explore the relationship between enhanced sympathetic nervous activity and lymphocyte subset distribution in three…”
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