Search Results - "Insall, R."

A computational method for the coupled solution of reaction–diffusion equations on evolving domains and manifolds: Application to a model of cell migration and chemotaxis by MacDonald, G., Mackenzie, J.A., Nolan, M., Insall, R.H.

“…In this paper, we devise a moving mesh finite element method for the approximate solution of coupled bulk–surface reaction–diffusion equations on an evolving…”
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Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model by Mackenzie, J. A., Nolan, M., Insall, R. H.

“…Chemoattractant gradients are usually considered in terms of sources and sinks that are independent of the chemotactic cell. However, recent interest has…”
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Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3 by Rozelle, A.L., Machesky, L.M., Yamamoto, M., Driessens, M.H.E., Insall, R.H., Roth, M.G., Luby-Phelps, K., Marriott, G., Hall, A., Yin, H.L.

“…Background: Phosphatidylinositol 4,5-bisphosphate (PIP2) has been implicated in the regulation of the actin cytoskeleton and vesicle trafficking. It stimulates…”
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Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex by Machesky, Laura M., Insall, Robert H.

“…Background: The actin-related proteins Arp2 and Arp3 are part of a seven-protein complex which is localized in the lamellipodia of a variety of cell types, and…”
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PIP3, PIP2, and Cell Movement—Similar Messages, Different Meanings? by Insall, Robert H., Weiner, Orion D.

“…The inositol lipids PI(4,5)P 2 and PI(3,4,5)P 3 are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest…”
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The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium by Insall, Robert H., Borleis, Jane, Devreotes, Peter N.

“…Background Ras proteins are small GTP-binding proteins that play an essential role in a wide range of processes, particularly in mammalian growth control. They…”
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Ruptured Thyrocervical Trunk Aneurysm in a Patient with Type I Neurofibromatosis by Al-Jundi, W, Matheiken, S, Abdel-Rehim, S, Diwakar, P, Insall, R

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Regulation of actin assembly by SCAR/WAVE proteins by Ibarra, N, Pollitt, A, Insall, R H

“…Actin reorganization is a tightly regulated process that co-ordinates complex cellular events, such as cell migration, chemotaxis, phagocytosis and adhesion,…”
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PIR121 Regulates Pseudopod Dynamics and SCAR Activity in Dictyostelium by Blagg, Simone L., Stewart, Michael, Sambles, Christine, Insall, Robert H.

“…Background: The WASP/SCAR family of adaptor proteins coordinates actin reorganization by coupling different signaling molecules, including Rho-family GTPases,…”
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Signaling to Actin Dynamics by Machesky, Laura M., Insall, Robert H.

“…The actin cytoskeleton of a eukaryotic cell is central to locomotion, contractility, phagocytosis, shape changes, cytokinesis, and maintenance of polarity…”
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A major role for Scar/WAVE‐1 downstream of GPVI in platelets by CALAMINUS, S. D. J., MCCARTY, O. J. T., AUGER, J. M., PEARCE, A. C., INSALL, R. H., WATSON, S. P., MACHESKY, L. M.

“…Background: The small GTPase Rac1 plays a critical role in lamellipodia assembly in platelets on matrix proteins in the absence or presence of G…”
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Control of SCAR activity in Dictyostelium discoideum by Blagg, S L, Insall, R H

“…The WASP (Wiskott-Aldrich syndrome protein)/SCAR (suppressor of cAMP receptor) family of adaptor proteins regulate actin polymerization by coupling Rho-family…”
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The RACE to protect brain by Rix, T. E., Singh, I., Gunaratnam, G., Baht, H. S., Hargroves, D., Insall, R., Senaratne, J.

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CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium by Insall, R. (Johns Hopkins University, Baltimore, MD.), Kuspa, A, Lilly, P.J, Shaulsky, G, Levin, L.R, Loomis, W.F, Devreotes, P

“…Adenylyl cyclase in Dictyostelium, as in higher eukaryotes, is activated through G protein-coupled receptors. Insertional mutagenesis into a gene designated…”
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Life After Gala by Krysa, J, Kovalic, A, Kadam, S, Thambawita, H, Insall, R, Senaratne, J

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The enemy within. My word by Insall, R

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The PKB that doesn’t need to jump by Insall, Robert

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Too much of a good thing? by Insall, R

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Signaling through chemoattractant receptors in Dictyostelium by Chen, Mei-Yu, Insall, Robert H., Devreotes, Peter N.

“…Dictyostellium discoideum displays chemoattractant-directed cell migration typical of many higher cell types. Signalling through chemoattractant receptors…”
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Reducing surgical outpatient waiting is not the solution to meeting the 2005 colorectal cancer target by Rao, G. N., Basnyat, P., Taffinder, N., Hudson, C., Insall, R.

“…Objectives  The majority of colorectal cancers (CRC) are not diagnosed through the Rapid access route (RAR) and follow‐ups (FU) may prolong outpatient‐waiting…”
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