Search Results - "Insaf, Shabana"

Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine by Salaski, Edward J, Krishnamurthy, Girija, Ding, Wei-Dong, Yu, Ker, Insaf, Shabana S, Eid, Clark, Shim, Jaechul, Levin, Jeremy I, Tabei, Keiko, Toral-Barza, Lourdes, Zhang, Wei-Guo, McDonald, Leonard A, Honores, Erick, Hanna, Cilien, Yamashita, Ayako, Johnson, Bernard, Li, Zhong, Laakso, Leif, Powell, Dennis, Mansour, Tarek S

“…The naturally occurring pyranonaphthoquinone (PNQ) antibiotic lactoquinomycin and related aglycones were found to be selective inhibitors of the…”
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Synthesis of All Distinct α-Methyl-Substituted Isomers of Amino Bis(2,2′-Ethanoic Acid) Diethyl Ester and Ethylene Diamine Tetraacetic Acid Tetraethyl Ester Scaffolds by Insaf, Shabana S, Witiak, Donald T

“…The syntheses of three dialkylated and six tetraalkylated ethylene diamine tetraacetic acid tetraesters is described. The dialkylated derivatives were…”
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Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase by Nittoli, Thomas, Curran, Kevin, Insaf, Shabana, DiGrandi, Martin, Orlowski, Mark, Chopra, Rajiv, Agarwal, Atul, Howe, Anita Y. M, Prashad, Amar, Floyd, M. Brawner, Johnson, Bernard, Sutherland, Alan, Wheless, Karen, Feld, Boris, O'Connell, John, Mansour, Tarek S, Bloom, Jonathan

“…A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the…”
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Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors by Gopalsamy, Ariamala, Lim, Kitae, Ciszewski, Gregory, Park, Kaapjoo, Ellingboe, John W, Bloom, Jonathan, Insaf, Shabana, Upeslacis, Janis, Mansour, Tarek S, Krishnamurthy, Girija, Damarla, Murthy, Pyatski, Yelena, Ho, Douglas, Howe, Anita Y. M, Orlowski, Mark, Feld, Boris, O'Connell, John

“…A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound…”
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The Propensities of Amino Acids To Form Parallel β-Sheets by Nowick, James S, Insaf, Shabana

“…This paper reports synthetic and structural studies of a 16-membered combinatorial library of chemical models for parallel β-sheets (1) and two four-membered…”
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Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase by Nittoli, Thomas, Curran, Kevin, Insaf, Shabana, DiGrandi, Martin, Orlowski, Mark, Chopra, Rajiv, Agarwal, Atul, Howe, Anita Y. M, Prashad, Amar, Floyd, M. Brawner, Johnson, Bernard, Sutherland, Alan, Wheless, Karen, Feld, Boris, O'Connell, John, Mansour, Tarek S, Bloom, Jonathan

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Extension of the Polyanionic Cosalane Pharmacophore as a Strategy for Increasing Anti-HIV Potency by Cushman, Mark, Insaf, Shabana, Paul, Gitendra, Ruell, Jeffrey A, De Clercq, Erik, Schols, Dominique, Pannecouque, Christophe, Witvrouw, Myriam, Schaeffer, Catherine A, Turpin, Jim A, Williamson, Karen, Rice, William G

“…The anti-HIV agent cosalane inhibits both the binding of gp120 to CD4 as well as an undefined postattachment event prior to reverse transcription. Several…”
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Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds by Howard, O.M.Zack, Dong, Hui Fang, Oppenheim, Joost J., Insaf, Shabana, Santhosh, Kalpathy C., Paul, Gitendra, Cushman, Mark

“…The anti-HIV agent cosalane and several of its analogues inhibited RANTES-induced migration of human monocytes, but they did not inhibit migration induced by…”
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Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent by Cushman, Mark, Insaf, Shabana, Ruell, Jeffrey A., Schaeffer, Catherine A., Rice, William G.

“…A novel cosalane analog having an extended polyanionic pharmacophore was synthesized in order to target specific cationic residues on the surface of CD4. The…”
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Design and synthesis of stereochemically defined bis(dioxopiperazine) analogs as topoisomerase II inhibitors by Insaf, Shabana Shahid

“…Recently, DNA topoisomerases have been recognized as viable chemotherapeutic targets. DNA topoisomerases are ubiquitous enzymes that catalyze the…”
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