Significance of Serum Fungal Inhibitory Factor in Dermatophytosis

An in vitro agar-diffusion system was used to assay human serum for inhibition of Trichophyton mentagrophytes growth. Sera were obtained for 30 adults representative of three major classes of susceptibility to dermatophytosis: (1) immunologically nonexperienced, (2) experienced immune, and (3) chron...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of investigative dermatology Vol. 63; no. 2; pp. 239 - 241
Main Authors:	Carlisle, D.H., Inouye, J.C., King, R.D., Jones, H.E.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-1974
Subjects:	Animals Cattle Dermatomycoses - blood Dermatomycoses - immunology Humans Immunity Immunodiffusion Male Trichophyton - growth & development Trichophyton - immunology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	An in vitro agar-diffusion system was used to assay human serum for inhibition of Trichophyton mentagrophytes growth. Sera were obtained for 30 adults representative of three major classes of susceptibility to dermatophytosis: (1) immunologically nonexperienced, (2) experienced immune, and (3) chronically infected. Although the three classes represent polar degrees of resistance/susceptibility to infection, there was no significant difference in the inhibitory power of their sera. Furthermore, nonexperienced subjects undergoing a primary infection were not found to acquire any increase in serum inhibitory activity, despite the simultaneous acquisition of a strong relative immunity. Nevertheless, other evidence suggests this unknown factor may play a role in defense against dermatophyte infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-202X 1523-1747
DOI:	10.1111/1523-1747.ep12680020