Search Results - "Inouye, Hideyo"

Utility of Solution X-Ray Scattering for the Development of Antibody Biopharmaceuticals by Inouye, Hideyo, Houde, Damian, Temel, Deniz B, Makowski, Lee

“…Characterization of immunoglobulin solutions at high concentrations represents a significant challenge. A current trend in the biopharmaceutical industry is to…”
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Differential effects of phe19 and phe20 on fibril formation by amyloidogenic peptide Aβ16-22 (Ac-KLVFFAE-NH2) by Inouye, Hideyo, Gleason, Katherine A., Zhang, Dong, Decatur, Sean M., Kirschner, Daniel A.

“…The sequence KLVFFAE (Aβ16–22) in Alzheimer's β‐amyloid is thought to be a core β‐structure that could act as a template for folding other parts of the…”
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Myelin organization in the nodal, paranodal, and juxtaparanodal regions revealed by scanning x-ray microdiffraction by Inouye, Hideyo, Liu, Jiliang, Makowski, Lee, Palmisano, Marilena, Burghammer, Manfred, Riekel, Christian, Kirschner, Daniel A

“…X-ray diffraction has provided extensive information about the arrangement of lipids and proteins in multilamellar myelin. This information has been limited to…”
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The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study by Cantu’, Laura, Colombo, Laura, Stoilova, Tatiana, Demé, Bruno, Inouye, Hideyo, Booth, Rachel, Rondelli, Valeria, Di Fede, Giuseppe, Tagliavini, Fabrizio, Del Favero, Elena, Kirschner, Daniel A., Salmona, Mario

“…We have described a novel C-to-T mutation in the APP gene that corresponds to an alanine to valine substitution at position 673 in APP (A673V), or position 2…”
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The Formation of Straight and Twisted Filaments from Short Tau Peptides by Goux, Warren J., Kopplin, Lauren, Nguyen, Anh D., Leak, Kathryn, Rutkofsky, Marni, Shanmuganandam, Vasanthi D., Sharma, Deepak, Inouye, Hideyo, Kirschner, Daniel A.

“…We studied fibril formation in a family of peptides based on PHF6 (VQIVYK), a short peptide segment found in the microtubule binding region of tau protein…”
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SCAP is required for timely and proper myelin membrane synthesis by Verheijen, Mark H.G, Camargo, Nutabi, Verdier, Valerie, Nadra, Karim, de Preux Charles, Anne-Sophie, Médard, Jean-Jacques, Luoma, Adrienne, Crowther, Michelle, Inouye, Hideyo, Shimano, Hitoshi, Chen, Su, Brouwers, Jos F, Helms, J. Bernd, Feltri, M. Laura, Wrabetz, Lawrence, Kirschner, Daniel, Chrast, Roman, Smit, August.B

“…Myelination requires a massive increase in glial cell membrane synthesis. Here, we demonstrate that the acute phase of myelin lipid synthesis is regulated by…”
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Structure of Core Domain of Fibril-Forming PHF/Tau Fragments by Inouye, Hideyo, Sharma, Deepak, Goux, Warren J., Kirschner, Daniel A.

“…Short peptide sequences within the microtubule binding domain of the protein Tau are proposed to be core nucleation sites for formation of amyloid fibrils…”
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Fiber diffraction as a screen for amyloid inhibitors by Kirschner, Daniel A, Gross, Abby A R, Hidalgo, Marla M, Inouye, Hideyo, Gleason, Katherine A, Abdelsayed, George A, Castillo, Gerardo M, Snow, Alan D, Pozo-Ramajo, Angela, Petty, Sarah A, Decatur, Sean M

“…Targeting the initial formation of amyloid assemblies is a preferred approach to therapeutic intervention in amyloidoses, which include such diseases as…”
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X-ray Diffraction of Scrapie Prion Rods and PrP Peptides by Nguyen, Jack T., Inouye, Hideyo, Baldwin, Michael A., Fletterick, Robert J., Cohen, Fred E., Prusiner, Stanley B., Kirschner, Daniel A.

“…Certain neurodegenerative diseases in humans and animals are caused by small proteinaceous infectious particles called prions. Limited proteolysis and…”
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Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid .beta.-protein by Fraser, Paul E, Nguyen, Jack T, Inouye, Hideyo, Surewicz, Witold K, Selkoe, Dennis J, Podlisny, Marcia B, Kirschner, Daniel A

“…Deposition of extraneuronal fibrils that assemble from the 39-43 residue beta/A4 amyloid protein is one of the earliest histopathological features of…”
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Evolution of myelin ultrastructure and the major structural myelin proteins by Inouye, Hideyo, Kirschner, Daniel A

“…Abstract Myelin sheaths, as the specialized tissue wrapping the nerve fibers in the central and peripheral nervous systems (CNS and PNS), are responsible for…”
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Tetrameric Assembly of Full-Sequence Protein Zero Myelin Glycoprotein by Synchrotron X-Ray Scattering by Inouye, Hideyo, Tsuruta, Hiro, Sedzik, Jan, Uyemura, Keiichi, Kirschner, Daniel A.

“…Highly purified myelin P0 glycoprotein was solubilized to 1–8 mg/ml in 0.1% sodium dodecyl sulfate (SDS), and the solution structure of the P0 assembly was…”
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Diffraction pattern simulation of cellulose fibrils using distributed and quantized pair distances by Zhang, Yan, Inouye, Hideyo, Crowley, Michael, Yu, Leiming, Kaeli, David, Makowski, Lee

“…Intensity simulation of X‐ray scattering from large twisted cellulose molecular fibrils is important in understanding the impact of chemical or physical…”
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Myelin structure in unfixed, single nerve fibers: Scanning X-ray microdiffraction with a beam size of 200 nm by Inouye, Hideyo, Kuo, Fong-Hsu, Denninger, Andrew R., Weinhausen, Britta, Burghammer, Manfred, Kirschner, Daniel A.

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Diffraction pattern simulation of cellulose fibrils using distributed and quantized pair distances by Zhang, Yan, Inouye, Hideyo, Crowley, Michael, Yu, Leiming, Kaeli, David, Makowski, Lee

“…Intensity simulation of X-ray scattering from large twisted cellulose molecular fibrils is important in understanding the impact of chemical or physical…”
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A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies by Krishnan, Rajaraman, Tsubery, Haim, Proschitsky, Ming Y., Asp, Eva, Lulu, Michal, Gilead, Sharon, Gartner, Myra, Waltho, Jonathan P., Davis, Peter J., Hounslow, Andrea M., Kirschner, Daniel A., Inouye, Hideyo, Myszka, David G., Wright, Jason, Solomon, Beka, Fisher, Richard A.

“…Misfolded protein aggregates, characterized by a canonical amyloid fold, play a central role in the pathobiology of neurodegenerative diseases. Agents that…”
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Differential effects of Phe19 and Phe20 on fibril formation by amyloidogenic peptide A beta 16-22 (Ac-KLVFFAE-NH2) by Inouye, Hideyo, Gleason, Katherine A, Zhang, Dong, Decatur, Sean M, Kirschner, Daniel A

“…The sequence KLVFFAE (A beta 16-22) in Alzheimer's beta-amyloid is thought to be a core beta-structure that could act as a template for folding other parts of…”
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Myelin structure in unfixed, single nerve fibers: Scanning X-ray microdiffraction with a beam size of 200nm by Inouye, Hideyo, Kuo, Fong-Hsu, Denninger, Andrew R., Weinhausen, Britta, Burghammer, Manfred, Kirschner, Daniel A.

“…Previous raster-scanning with a 1μm X-ray beam of individual, myelinated fibers from glutaraldehyde-fixed rat sciatic nerve revealed a spatially-dependent…”
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Breakdown of hierarchical architecture in cellulose during dilute acid pretreatments by Zhang, Yan, Inouye, Hideyo, Yang, Lin, Himmel, Michael E, Tucker, Melvin, Makowski, Lee

“…Cellulose is an attractive candidate as a feedstock for sustainable bioenergy because of its global abundance. Pretreatment of biomass has significant…”
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Myelin membrane structure and composition correlated: a phylogenetic study by Kirschner, D A, Inouye, H, Ganser, A L, Mann, V

“…We have correlated myelin membrane structure with biochemical composition in the CNS and PNS of a phylogenetic series of animals, including elasmobranchs,…”
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