Search Results - "Inoue, Yasuteru"

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease by Inoue, Yasuteru, Shue, Francis, Bu, Guojun, Kanekiyo, Takahisa

“…Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of…”
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Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus by Inoue, Yasuteru, Masuda, Teruaki, Misumi, Yohei, Ando, Yukio, Ueda, Mitsuharu

“…[Display omitted] •Metformin reduced cerebral Aβ in APP23-ob/ob mice and mixed model CAA-T2DM mice..•Metformin reduced hippocampal and cortical soluble and…”
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Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy by Inoue, Yasuteru, Ando, Yukio, Misumi, Yohei, Ueda, Mitsuharu

“…Cerebral amyloid angiopathy (CAA) is characterized by accumulation of amyloid β (Aβ) in walls of leptomeningeal vessels and cortical capillaries in the brain…”
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Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease by Liu, Chia-Chen, Wang, Na, Chen, Yuanxin, Inoue, Yasuteru, Shue, Francis, Ren, Yingxue, Wang, Minghui, Qiao, Wenhui, Ikezu, Tadafumi C., Li, Zonghua, Zhao, Jing, Martens, Yuka, Doss, Sydney V., Rosenberg, Cassandra L., Jeevaratnam, Suren, Jia, Lin, Raulin, Ana-Caroline, Qi, Fangfang, Zhu, Yiyang, Alnobani, Alla, Knight, Joshua, Chen, Yixing, Linares, Cynthia, Kurti, Aishe, Fryer, John D., Zhang, Bin, Wu, Long-Jun, Kim, Betty Y. S., Bu, Guojun

“…Microglial involvement in Alzheimer’s disease (AD) pathology has emerged as a risk-determining pathogenic event. While apolipoprotein E ( APOE ) is known to…”
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Low Serum Calcium Levels Contribute to Larger Hematoma Volume in Acute Intracerebral Hemorrhage by Inoue, Yasuteru, Miyashita, Fumio, Toyoda, Kazunori, Minematsu, Kazuo

“…BACKGROUND AND PURPOSE—We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients…”
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Memantine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression by Inoue, Yasuteru, Ueda, Mitsuharu, Masuda, Teruaki, Misumi, Yohei, Yamashita, Taro, Ando, Yukio

“…Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid beta (Aβ) deposits and causes cerebral hemorrhages and dementia in…”
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Reversible Periventricular Hyperintensity Lesions in Cerebral Amyloid Angiopathy: A Case Mimicking Cerebral Amyloid Angiopathy-related Inflammation by Inoue, Yasuteru, Nakajima, Makoto, Inatomi, Yuichiro, Masuda, Teruaki, Misumi, Yohei, Nomura, Toshiya, Uetani, Hiroyuki, Hirai, Toshinori, Ueda, Mitsuharu

“…A 59-year-old man with progressive cognitive decline and mood disturbances was admitted to the hospital. Brain magnetic resonance imaging revealed marked white…”
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Clinical Characteristics and Outcomes of Intracerebral Hemorrhage in Very Elderly by Inoue, Yasuteru, Miyashita, Fumio, Minematsu, Kazuo, Toyoda, Kazunori

“…Intracerebral hemorrhage (ICH) incidences increase with age. Patients of advanced age may have limitations during acute care and recovery. We investigated…”
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A novel age‐related venous amyloidosis derived from EGF‐containing fibulin‐like extracellular matrix protein 1 by Tasaki, Masayoshi, Ueda, Mitsuharu, Hoshii, Yoshinobu, Mizukami, Mayumi, Matsumoto, Sayaka, Nakamura, Makoto, Yamashita, Taro, Ueda, Akihiko, Misumi, Yohei, Masuda, Teruaki, Inoue, Yasuteru, Torikai, Tessei, Nomura, Toshiya, Tsuda, Yukimoto, Kanenawa, Kyosuke, Isoguchi, Aito, Okada, Masamitsu, Matsui, Hirotaka, Obayashi, Konen, Ando, Yukio

“…Most intractable tissue‐degenerative disorders share a common pathogenic condition, so‐called proteinopathy. Amyloid‐related disorders are the most common…”
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Extreme Adhesion Activity of Amyloid Fibrils Induces Subcutaneous Insulin Resistance by Nakamura, Makoto, Misumi, Yohei, Nomura, Toshiya, Oka, Wakana, Isoguchi, Aito, Kanenawa, Kyosuke, Masuda, Teruaki, Yamashita, Taro, Inoue, Yasuteru, Ando, Yukio, Ueda, Mitsuharu

“…Insulin-derived amyloidoma, also called an insulin ball, is a skin-related complication of insulin therapy caused by repeated insulin injections at the same…”
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Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction by İş, Özkan, Wang, Xue, Reddy, Joseph S., Min, Yuhao, Yilmaz, Elanur, Bhattarai, Prabesh, Patel, Tulsi, Bergman, Jeremiah, Quicksall, Zachary, Heckman, Michael G., Tutor-New, Frederick Q., Can Demirdogen, Birsen, White, Launia, Koga, Shunsuke, Krause, Vincent, Inoue, Yasuteru, Kanekiyo, Takahisa, Cosacak, Mehmet Ilyas, Nelson, Nastasia, Lee, Annie J., Vardarajan, Badri, Mayeux, Richard, Kouri, Naomi, Deniz, Kaancan, Carnwath, Troy, Oatman, Stephanie R., Lewis-Tuffin, Laura J., Nguyen, Thuy, Carrasquillo, Minerva M., Graff-Radford, Jonathan, Petersen, Ronald C., Jr Jack, Clifford R., Kantarci, Kejal, Murray, Melissa E., Nho, Kwangsik, Saykin, Andrew J., Dickson, Dennis W., Kizil, Caghan, Allen, Mariet, Ertekin-Taner, Nilüfer

“…To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s…”
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Multifunctional Therapeutic Cyclodextrin-Appended Dendrimer Complex for Treatment of Systemic and Localized Amyloidosis by Inoue, Masamichi, Higashi, Taishi, Hayashi, Yuya, Onodera, Risako, Fujisawa, Kazuya, Taharabaru, Toru, Yokoyama, Ryoma, Ouchi, Kenta, Misumi, Yohei, Ueda, Mitsuharu, Inoue, Yasuteru, Mizuguchi, Mineyuki, Saito, Takashi, Saido, Takaomi C., Ando, Yukio, Arima, Hidetoshi, Motoyama, Keiichi, Jono, Hirofumi

“…Amyloidosis pathologically proceeds via production of amyloidogenic proteins by organs, formation of protein aggregates through structural changes, and their…”
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A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells by Inoue, Yasuteru, Ren, Yingxue, Zhang, Shuwen, Bamkole, Michael, Islam, Naeyma N, Selvaraj, Manikandan, Lu, Wenyan, Caulfield, Thomas R, Li, Yonghe, Kanekiyo, Takahisa

“…The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood-brain barrier (BBB). The BBB…”
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A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH by Ueda, Mitsuharu, Okada, Masamitsu, Mizuguchi, Mineyuki, Kluve-Beckerman, Barbara, Kanenawa, Kyosuke, Isoguchi, Aito, Misumi, Yohei, Tasaki, Masayoshi, Ueda, Akihiko, Kanai, Akinori, Sasaki, Ryoko, Masuda, Teruaki, Inoue, Yasuteru, Nomura, Toshiya, Shinriki, Satoru, Shuto, Tsuyoshi, Kai, Hirofumi, Yamashita, Taro, Matsui, Hirotaka, Benson, Merrill D., Ando, Yukio

“…Transthyretin (TTR) is a major amyloidogenic protein associated with hereditary (ATTRm) and nonhereditary (ATTRwt) intractable systemic transthyretin…”
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Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy by Inoue, Yasuteru, Ueda, Mitsuharu, Tasaki, Masayoshi, Takeshima, Akari, Nagatoshi, Akihito, Masuda, Teruaki, Misumi, Yohei, Kosaka, Takayuki, Nomura, Toshiya, Mizukami, Mayumi, Matsumoto, Sayaka, Yamashita, Taro, Takahashi, Hitoshi, Kakita, Akiyoshi, Ando, Yukio

“…Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid beta (Aβ) deposits and causes cerebral hemorrhage and dementia. The…”
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Natural history and long-term effects of variant protein reduction in non-V30M ATTR amyloidosis by Yamashita, Taro, Ueda, Mitsuharu, Nomura, Toshiya, Okazaki, Takahiro, Okada, Masamitsu, Tsuda, Yukimoto, Inoue, Yasuteru, Masuda, Teruaki, Misumi, Yohei, Takamatsu, Kotaro, Obayashi, Konen, Inomata, Yukihiro, Hibi, Taizo, Ando, Yukio

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Unclear-onset intracerebral hemorrhage: Clinical characteristics, hematoma features, and outcomes by Inoue, Yasuteru, Miyashita, Fumio, Koga, Masatoshi, Minematsu, Kazuo, Toyoda, Kazunori

“…Background and purpose Although unclear-onset ischemic stroke, including wake-up ischemic stroke, is drawing attention as a potential target for reperfusion…”
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Stroke Education Using an Animated Cartoon and a Manga for Junior High School Students by Shigehatake, Yuya, MD, Yokota, Chiaki, MD, Amano, Tatsuo, MD, Tomii, Yasuhiro, MD, Inoue, Yasuteru, MD, Hagihara, Takaaki, MD, Toyoda, Kazunori, MD, Minematsu, Kazuo, MD

“…Background We investigated whether junior high school students could be educated regarding stroke with an animated cartoon and a Manga that we produced for the…”
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Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy by Endo, Yoshinori, Hasegawa, Kazuhiro, Nomura, Ryo, Arishima, Hidetaka, Kikuta, Ken-Ichiro, Yamashita, Taro, Inoue, Yasuteru, Ueda, Mitsuharu, Ando, Yukio, Wilson, Mark R, Hamano, Tadanori, Nakamoto, Yasunari, Naiki, Hironobu

“…Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid-β (Aβ) deposition, which leads to lobar hemorrhage and dementia…”
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New simple and quick method to analyze serum variant transthyretins: direct MALDI method for the screening of hereditary transthyretin amyloidosis by Nomura, Toshiya, Ueda, Mitsuharu, Tasaki, Masayoshi, Misumi, Yohei, Masuda, Teruaki, Inoue, Yasuteru, Tsuda, Yukimoto, Okada, Masamitsu, Okazaki, Takahiro, Kanenawa, Kyosuke, Isoguchi, Aito, Nakamura, Makoto, Obayashi, Konen, Shinriki, Satoru, Matsui, Hirotaka, Yamashita, Taro, Ando, Yukio

“…Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is caused by a variant transthyretin (TTR), which is a serum protein secreted by the liver. Mass…”
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