Search Results - "Inoue, Ryuji"

SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation by Komatsu, Shiho, Nomiyama, Takashi, Numata, Tomohiro, Kawanami, Takako, Hamaguchi, Yuriko, Iwaya, Chikayo, Horikawa, Tsuyoshi, Fujimura-Tanaka, Yuki, Hamanoue, Nobuya, Motonaga, Ryoko, Tanabe, Makito, Inoue, Ryuji, Yanase, Toshihiko, Kawanami, Daiji

“…Cancer is currently one of the major causes of death in patients with type 2 diabetes mellitus. We previously reported the beneficial effects of the…”
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Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation by Hu, Yaopeng, Kaschitza, Daniela Ross, Essers, Maria, Arullampalam, Prakash, Fujita, Takayuki, Abriel, Hugues, Inoue, Ryuji

“…TRPM4 is a Ca 2+ -activated nonselective cation channel involved in cardiovascular physiology and pathophysiology. Based on cellular experiments and numerical…”
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The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis by Hu, Yaopeng, Cang, Jiehui, Hiraishi, Keizo, Fujita, Takayuki, Inoue, Ryuji

“…The transient receptor potential melastatin 4 (TRPM4) channel is a non-selective cation channel that activates in response to increased intracellular Ca levels…”
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TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells by Ichikawa, Jun, Inoue, Ryuji

“…Background and Purpose Ca2+ influx is important for cell cycle progression, but the mechanisms involved seem to vary. We investigated the potential roles of…”
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Endoscopic Biliary Intervention Using Traction Devices for Periampullary Diverticulum by Inoue, Ryuji, Kawakami, Hiroshi, Kubota, Yoshimasa, Ban, Tessin

“…We describe the case a 92-year-old woman who was admitted to our hospital with choledocholithiasis and periampullary diverticulum (PAD). Due to PAD, clear…”
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Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel by Sato-Numata, Kaori, Numata, Tomohiro, Inoue, Ryuji, Okada, Yasunobu

“…Expressed by many cell types, acid-sensitive outwardly rectifying (ASOR) anion channels are known to be activated by extracellular acidification and involved…”
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Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block by Hu, Yaopeng, Li, Qin, Shen, Yanghua, Fujita, Takayuki, Zhu, Xin, Inoue, Ryuji

“…In the heart, TRPM4 is most abundantly distributed in the conduction system. Previously, a single mutation, ‘E7K’, was identified in its distal N-terminus to…”
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TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy by Onohara, Naoya, Nishida, Motohiro, Inoue, Ryuji, Kobayashi, Hiroyuki, Sumimoto, Hideki, Sato, Yoji, Mori, Yasuo, Nagao, Taku, Kurose, Hitoshi

“…Angiotensin (Ang) II participates in the pathogenesis of heart failure through induction of cardiac hypertrophy. Ang II‐induced hypertrophic growth of…”
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Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells by Yoshimoto, Shohei, Matsuda, Miho, Kato, Kenichi, Jimi, Eijiro, Takeuchi, Hiroshi, Nakano, Shuji, Kajioka, Shunichi, Matsuzaki, Etsuko, Hirofuji, Takao, Inoue, Ryuji, Hirata, Masato, Morita, Hiromitsu

“…Volume-regulated anion channels (VRACs), expressed in various cells, play an important role in cell volume regulation. Despite being physiologically defined…”
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Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+ Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia by Mizoguchi, Yoshito, Kato, Takahiro A., Seki, Yoshihiro, Ohgidani, Masahiro, Sagata, Noriaki, Horikawa, Hideki, Yamauchi, Yusuke, Sato-Kasai, Mina, Hayakawa, Kohei, Inoue, Ryuji, Kanba, Shigenobu, Monji, Akira

“…Microglia are immune cells that release factors, including proinflammatory cytokines, nitric oxide (NO), and neurotrophins, following activation after…”
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Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation by Mori, Masayuki X., Okada, Ryo, Sakaguchi, Reiko, Hase, Hideharu, Imai, Yuko, Polat, Onur K., Itoh, Satoru G., Okumura, Hisashi, Mori, Yasuo, Okamura, Yasushi, Inoue, Ryuji

“…Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2 or PIP 2 ) regulates the activities of numerous membrane proteins, including diacylglycerol(DAG)-activated…”
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PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels by Itsuki, Kyohei, Imai, Yuko, Hase, Hideharu, Okamura, Yasushi, Inoue, Ryuji, Mori, Masayuki X

“…Transient receptor potential classical (or canonical) (TRPC)3, TRPC6, and TRPC7 are a subfamily of TRPC channels activated by diacylglycerol (DAG) produced…”
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Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes by Polat, Onur K., Uno, Masatoshi, Maruyama, Terukazu, Tran, Ha Nam, Imamura, Kayo, Wong, Chee Fah, Sakaguchi, Reiko, Ariyoshi, Mariko, Itsuki, Kyohei, Ichikawa, Jun, Morii, Takashi, Shirakawa, Masahiro, Inoue, Ryuji, Asanuma, Katsuhiko, Reiser, Jochen, Tochio, Hidehito, Mori, Yasuo, Mori, Masayuki X.

“…Significance Statement TRPC6 is a receptor-activated nonselective cation channel. Naturally occurring mutations in this channel are associated with FSGS…”
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Transient Receptor Potential Channels in Cardiovascular Function and Disease by Inoue, Ryuji, Jensen, Lars Jørn, Shi, Juan, Morita, Hiromitsu, Nishida, Motohiro, Honda, Akira, Ito, Yushi

“…Sustained elevation in the intracellular Ca concentration via Ca influx, which is activated by a variety of mechanisms, plays a central regulatory role for…”
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Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension by Hiraishi, Keizo, Kurahara, Lin Hai, Ishikawa, Kaori, Go, Tetsuhiko, Yokota, Naoya, Hu, Yaopeng, Fujita, Takayuki, Inoue, Ryuji, Hirano, Katsuya

“…Pulmonary arterial hypertension (PAH) is an intractable vascular disease characterized by a progressive increase in pulmonary vascular resistance caused by…”
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Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl−/water secretion that involves cAMP-dependent activation of CFTR by Numata, Tomohiro, Sato-Numata, Kaori, Okada, Yasunobu, Inoue, Ryuji

“…Constipation is a common symptom frequently compromising the quality of daily life. Several mechanistically different drugs have been used to mitigate…”
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Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart by Kinoshita, Hideyuki, Kuwahara, Koichiro, Nishida, Motohiro, Jian, Zhong, Rong, Xianglu, Kiyonaka, Shigeki, Kuwabara, Yoshihiro, Kurose, Hitoshi, Inoue, Ryuji, Mori, Yasuo, Li, Yuhao, Nakagawa, Yasuaki, Usami, Satoru, Fujiwara, Masataka, Yamada, Yuko, Minami, Takeya, Ueshima, Kenji, Nakao, Kazuwa

“…RATIONALE:Atrial and brain natriuretic peptides (ANP and BNP, respectively) exert antihypertrophic effects in the heart via their common receptor, guanylyl…”
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Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells by Kiyonaka, Shigeki, Kubota, Ryou, Michibata, Yukiko, Sakakura, Masayoshi, Takahashi, Hideo, Numata, Tomohiro, Inoue, Ryuji, Yuzaki, Michisuke, Hamachi, Itaru

“…The controlled activation of proteins in living cells is an important goal in protein-design research, but to introduce an artificial activation switch into…”
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Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches by Hu, Yaopeng, Duan, Yubin, Takeuchi, Ayako, Hai-Kurahara, Lin, Ichikawa, Jun, Hiraishi, Keizo, Numata, Tomohiro, Ohara, Hiroki, Iribe, Gentaro, Nakaya, Michio, Mori, Masayuki X, Matsuoka, Satoshi, Ma, Genshan, Inoue, Ryuji

“…Transient receptor potential cation channel subfamily melastatin member 4 (TRPM4), a Ca2+-activated nonselective cation channel abundantly expressed in the…”
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Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner by Nakamura, Yuki, Shi, Xiuyu, Numata, Tomohiro, Mori, Yasuo, Inoue, Ryuji, Lossin, Christoph, Baram, Tallie Z, Hirose, Shinichi

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated currents, known as I h, are involved in the control of rhythmic activity in neuronal…”
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