Search Results - "Inoue, Munenori"

Contribution of Organofluorine Compounds to Pharmaceuticals by Inoue, Munenori, Sumii, Yuji, Shibata, Norio

“…Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s, fluorine-containing pharmaceuticals, which are also…”
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Total Synthesis of (±)‐Phomoidride D by Leung, Joyce C., Bedermann, Aaron A., Njardarson, Jón T., Spiegel, David A., Murphy, Graham K., Hama, Naoto, Twenter, Barry M., Dong, Ping, Shirahata, Tatsuya, McDonald, Ivar M., Inoue, Munenori, Taniguchi, Nobuaki, McMahon, Travis C., Schneider, Christopher M., Tao, Nancy, Stoltz, Brian M., Wood, John L.

“…Described herein is a synthetic strategy for the total synthesis of (±)‐phomoidride D. This highly efficient and stereoselective approach provides rapid…”
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Facile synthesis of 1,7,8-trifluoro-2-naphthol via DMAP catalyzed cycloaromatization by Araki, Keisuke, Katagiri, Tomohiro, Inoue, Munenori

“…•1,7,8-Trifluoro-2-naphthol, a key synthetic intermediate for liquid crystal compounds with large dielectric anisotropy value, was synthesized.•DMAP catalyzed…”
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Calibration Technique Using Nonlinear Region in Cantilever Magnetometry Experiments and Presence of Universal Curve by Torizuka, Kiyoshi, Tajima, Hiroyuki, Yoshida, Gosuke, Inoue, Munenori

“…We have presented a calibration technique for commercially available atomic force microscopy (AFM) cantilevers used in torque magnetometry experiments. The…”
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Iterative two-step strategy for C2–C4′ linked poly-oxazole synthesis using Suzuki–Miyaura cross-coupling reaction by Araki, Hiroshi, Katoh, Tadashi, Inoue, Munenori

“…An iterative method for the synthesis of C2–C4′ linked poly-oxazoles has been developed. An iterative method for the synthesis of C2–C4′ linked poly-oxazoles…”
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Synthetic Studies toward GKK1032s, Novel Antibiotic Antitumor Agents:  Enantioselective Synthesis of the Fully Elaborated Tricyclic Core via an Intramolecular Diels−Alder Cycloaddition by Asano, Moriteru, Inoue, Munenori, Watanabe, Kazuhiro, Abe, Hideki, Katoh, Tadashi

“…An enantioselective synthesis of the fully elaborated tricyclic decahydrofluorene core (ABC-ring system) of GKK1032s, novel antimicrobial and antitumor agents,…”
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Total Synthesis of (+)-Scyphostatin, a Potent and Specific Inhibitor of Neutral Sphingomyelinase by Inoue, Munenori, Yokota, Wakako, Murugesh, Modachur G., Izuhara, Takashi, Katoh, Tadashi

“…The five crucial steps in the first total synthesis of (+)‐scyphostatin from D‐arabinose involve (see picture): a) stereoselective aldol coupling to form a…”
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Cobalt-catalyzed cross-coupling reaction of arylzinc reagents with ethyl bromodifluoroacetate by Araki, Keisuke, Inoue, Munenori

“…Transition metal-catalyzed cross-coupling reactions of arylmetal reagents with ethyl bromodifluoroacetate have been explored. After intensive investigations,…”
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Enantiocontrolled synthesis of the epoxycyclohexenone moieties of scyphostatin, a potent and specific inhibitor of neutral sphingomyelinase by Katoh, Tadashi, Izuhara, Takashi, Yokota, Wakako, Inoue, Munenori, Watanabe, Kazuhiro, Nobeyama, Ayaka, Suzuki, Takeyuki

“…The epoxycyclohexenone moieties 2 and 3b of scyphostatin ( 1 ), a potent and specific inhibitor of neutral sphingomyelinase, were synthesized in…”
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Total Synthesis and Absolute Configuration of Otteliones A and B, Novel and Potent Antitumor Agents from a Freshwater Plant by Araki, Hiroshi, Inoue, Munenori, Katoh, Tadashi

“…The first enantioselective total synthesis of otteliones A and B, biologically important and structurally novel natural products, has been successfully…”
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Enantioselective Total Synthesis of (−)-Candelalide A, a Novel Blocker of the Voltage-Gated Potassium Channel Kv1.3 for an Immunosuppressive Agent by Watanabe, Kazuhiro, Iwasaki, Katsuhiko, Abe, Toshiaki, Inoue, Munenori, Ohkubo, Kôichi, Suzuki, Takeyuki, Katoh, Tadashi

“…A convergent route to (−)-candelalide A involved the union of a trans-decalin portion (AB ring) and a γ-pyrone moiety through the C16−C3‘ bond to assemble the…”
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A New Strategy toward the Total Synthesis of Stachyflin, A Potent Anti-Influenza A Virus Agent:  Concise Route to the Tetracyclic Core Structure by Nakatani, Mari, Nakamura, Masahiko, Suzuki, Akiyuki, Inoue, Munenori, Katoh, Tadashi

“…A new strategy directed toward the total synthesis of stachyflin, a potent and novel anti-influenza A virus agent isolated from a microorganism, has been…”
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Convergent and enantioselective total synthesis of (−)-nalanthalide, a potential Kv1.3 blocking immunosuppressant by Abe, Toshiaki, Iwasaki, Katsuhiko, Inoue, Munenori, Suzuki, Takeyuki, Watanabe, Kazuhiro, Katoh, Tadashi

“…The first total synthesis of (−)-nalanthalide ( 1 ), a novel blocker of the voltage-gated potassium channel Kv1.3 from a microorganism, was accomplished in a…”
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Bromodifluoromethylation of aromatic Grignard reagents with CF2Br2 by Shiosaki, Masahiro, Inoue, Munenori

“…[Display omitted] The bromodifluoromethylation of aromatic Grignard reagents having electron-withdrawing groups with dibromodifluoromethane (CF2Br2) was…”
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An efficient synthesis of (+)-aureol via boron trifluoride etherate-promoted rearrangement of (+)-arenarol by Nakamura, Masahiko, Suzuki, Akiyuki, Nakatani, Mari, Fuchikami, Takamasa, Inoue, Munenori, Katoh, Tadashi

“…A novel marine natural product, (+)-aureol ( 1 ), was efficiently synthesized starting from the cis-fused decalin derivative 4 . The synthetic method features…”
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Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: an efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596 by Katoh, Tadashi, Ohmori, Osamu, Iwasaki, Katsuhiko, Inoue, Munenori

“…An efficient and facile synthesis of (±)-geodin [(±)- 2 ] corresponding to the spirocoumaranone part of Sch 202596 ( 1 ) was accomplished in a convergent…”
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An Expeditious Approach toward the Total Synthesis of CP-263,114 by Njardarson, Jón T, McDonald, Ivar M, Spiegel, David A, Inoue, Munenori, Wood, John L

“…Assembly of the carbocyclic core of CP-263,114 has been accomplished efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular…”
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Studies toward the total synthesis of (−)-kampanol A: an efficient construction of the ABCD ring system by Iwasaki, Katsuhiko, Nakatani, Mari, Inoue, Munenori, Katoh, Tadashi

“…The optically active tetracyclic ABCD ring system 2 of (−)-kampanol A ( 1 ), a novel Ras farnesyltransferase inhibitor from a microorganism, was efficiently…”
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Dibromofluoromethylation of aryl Grignard reagents with dibromodifluoromethane in the presence of LiBr by Shiosaki, Masahiro, Inoue, Munenori

“…•The dibromofluoromethylation of aryl Grignard reagents was developed.•The reaction proceeded via a difluorocarbene-mediated…”
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Synthesis of 3‐CF3‐Indoles from HFO‐1234ze(E) via Cross‐Coupling and Intramolecular Cyclization by Mizuno, Shota, Yotsume, Futa, Kasahara, Runa, Inoue, Munenori, Ichikawa, Junji, Fujita, Takeshi

“…The synthesis of indoles with a trifluoromethyl group has attracted a lot of attention because they are promising structural subunits for pharmaceuticals and…”
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