Search Results - "Inoue, Makiko"

Discovery of Imidazo[1,2‑b]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity by Kusakabe, Ken-ichi, Ide, Nobuyuki, Daigo, Yataro, Itoh, Takeshi, Yamamoto, Takahiko, Hashizume, Hiroshi, Nozu, Kohei, Yoshida, Hiroshi, Tadano, Genta, Tagashira, Sachie, Higashino, Kenichi, Okano, Yousuke, Sato, Yuji, Inoue, Makiko, Iguchi, Motofumi, Kanazawa, Takayuki, Ishioka, Yukichi, Dohi, Keiji, Kido, Yasuto, Sakamoto, Shingo, Ando, Shigeru, Maeda, Masahiro, Higaki, Masayo, Baba, Yoshiyasu, Nakamura, Yusuke

“…Monopolar spindle 1 (Mps1) is an attractive oncology target due to its high expression level in cancer cells as well as the correlation of its expression…”
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Establishment of a tissue-specific RNAi system in C. elegans by Qadota, Hiroshi, Inoue, Makiko, Hikita, Takao, Köppen, Mathias, Hardin, Jeffrey D., Amano, Mutsuki, Moerman, Donald G., Kaibuchi, Kozo

“…In C. elegans, mosaic analysis is a powerful genetic tool for determining in which tissue or specific cells a gene of interest is required. For traditional…”
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Indazole-Based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125) by Kusakabe, Ken-ichi, Ide, Nobuyuki, Daigo, Yataro, Tachibana, Yuki, Itoh, Takeshi, Yamamoto, Takahiko, Hashizume, Hiroshi, Hato, Yoshio, Higashino, Kenichi, Okano, Yousuke, Sato, Yuji, Inoue, Makiko, Iguchi, Motofumi, Kanazawa, Takayuki, Ishioka, Yukichi, Dohi, Keiji, Kido, Yasuto, Sakamoto, Shingo, Yasuo, Kazuya, Maeda, Masahiro, Higaki, Masayo, Ueda, Kazuo, Yoshizawa, Hidenori, Baba, Yoshiyasu, Shiota, Takeshi, Murai, Hitoshi, Nakamura, Yusuke

“…Monopolar spindle 1 (Mps1) is essential for centrosome duplication, the spindle assembly check point, and the maintenance of chromosomal instability. Mps1 is…”
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Preclinical antitumor activity of S‐222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2 by Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka

“…Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are validated molecular targets in cancer therapy. Dual blockade…”
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Inflammatory cytokine levels in synovial fluid 3, 4 days postoperatively and its correlation with early-phase functional recovery after anterior cruciate ligament reconstruction: a cohort study by Inoue, Makiko, Muneta, Takeshi, Ojima, Miyoko, Nakamura, Kaori, Koga, Hideyuki, Sekiya, Ichiro, Okazaki, Mutsumi, Tsuji, Kunikazu

“…Background Synovial fluid was collected prior to and at 3 to 4 days after ACL reconstruction to investigate the correlation between inflammatory cytokine…”
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Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors by Suzuki, Naoyuki, Shiota, Takeshi, Watanabe, Fumihiko, Haga, Norihiro, Murashi, Takami, Ohara, Takafumi, Matsuo, Kenji, Oomori, Naoki, Yari, Hiroshi, Dohi, Keiji, Inoue, Makiko, Iguchi, Motofumi, Sentou, Jyunko, Wada, Tooru

“…A structure–activity relationship study of 4-anilinopyrimidines for dual EGFR/Her-2 inhibitor has resulted in the identification of 4-anilino-5-alkenyl or…”
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Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan by Muneta, Takeshi, Inoue, Makiko, Abula, Kahaer, Matsukura, Yu, Miyatake, Kazumasa, Tsuji, Kunikazu, Yamada, Jun, Sekiya, Ichiro

“…Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins…”
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Detailed analysis of formation of chicken pituitary primordium in early embryonic development by Takagi, Hiroyasu, Nagashima, Keiko, Inoue, Makiko, Sakata, Ichiro, Sakai, Takafumi

“…The primordium of the mammalian adenohypophysis derived from Rathke’s pouch (RP) is known to be formed by oral ectoderm invagination. However, in the early…”
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Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation by Kusakabe, Ken-ichi, Ide, Nobuyuki, Daigo, Yataro, Itoh, Takeshi, Higashino, Kenichi, Okano, Yousuke, Tadano, Genta, Tachibana, Yuki, Sato, Yuji, Inoue, Makiko, Wada, Tooru, Iguchi, Motofumi, Kanazawa, Takayuki, Ishioka, Yukichi, Dohi, Keiji, Tagashira, Sachie, Kido, Yasuto, Sakamoto, Shingo, Yasuo, Kazuya, Maeda, Masahiro, Yamamoto, Takahiko, Higaki, Masayo, Endoh, Takeshi, Ueda, Kazuo, Shiota, Takeshi, Murai, Hitoshi, Nakamura, Yusuke

“…Monopolar spindle 1 (Mps1) is an attractive cancer drug target due to the important role that it plays in centrosome duplication, the spindle assembly…”
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The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans by Soto, Martha C, Qadota, Hiroshi, Kasuya, Katsuhisa, Inoue, Makiko, Tsuboi, Daisuke, Mello, Craig C, Kaibuchi, Kozo

“…During body morphogenesis precisely coordinated cell movements and cell shape changes organize the newly differentiated cells of an embryo into functional…”
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Detailed morphogenetic analysis of the embryonic chicken pars tuberalis as glycoprotein alpha subunit positive region by Inoue, Makiko, Aizawa, Sayaka, Higaki, Yuriko, Kawashima, Akira, Koike, Kanako, Takagi, Hiroyasu, Sakai, Takafumi, Sakata, Ichiro

“…The pars tuberalis (PT) is a part of the anterior pituitary gland that is located as a thin cell layer surrounding the median eminence. The characteristics of…”
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Dynamic Tip Front Dimension in Diffusion-limited Aggregation by Ohta, Shonosuke, Inoue, Makiko

“…A new fractal dimension of diffusion-limited aggregation (DLA) is studied by tip front angle near hottest branch projecting bare field, which is obtained from…”
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Spatiotemporal distribution and resource use of scoliid wasps (Hymenoptera) in coastal sand dunes by INOUE, Makiko, ENDO, Tomoji

“…The spatial and temporal distributions of scoliid wasps in the coastal sand dunes at Hakoishi, Kyoto Prefecture, Japan, were investigated using three different…”
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Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age by Abula, Kahaer, Muneta, Takeshi, Miyatake, Kazumasa, Yamada, Jun, Matsukura, Yu, Inoue, Makiko, Sekiya, Ichiro, Graf, Daniel, Economides, Aris N., Rosen, Vicki, Tsuji, Kunikazu

“…•Physiological roles of BMP7 in joint formation and homeostasis were examined.•Loss of BMP7 did not affect joint formation.•Proteoglycan contents were reduced…”
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Simple and tunable Förster resonance energy transfer-based bioprobes for high-throughput monitoring of caspase-3 activation in living cells by using flow cytometry by Suzuki, Miho, Tanaka, Satoshi, Ito, Yoichiro, Inoue, Makiko, Sakai, Takafumi, Nishigaki, Koichi

“…Sensing systems based on Förster resonance energy transfer (FRET) can be used to monitor enzymatic reactions, protein–protein interactions, changes in…”
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A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity by Kusakabe, Ken-ichi, Ide, Nobuyuki, Daigo, Yataro, Itoh, Takeshi, Yamamoto, Takahiko, Kojima, Eiichi, Mitsuoka, Yasunori, Tadano, Genta, Tagashira, Sachie, Higashino, Kenichi, Okano, Yousuke, Sato, Yuji, Inoue, Makiko, Iguchi, Motofumi, Kanazawa, Takayuki, Ishioka, Yukichi, Dohi, Keiji, Kido, Yasuto, Sakamoto, Shingo, Ando, Shigeru, Maeda, Masahiro, Higaki, Masayo, Yoshizawa, Hidenori, Murai, Hitoshi, Nakamura, Yusuke

“…[Display omitted] Mps1, also known as TTK, is a dual-specificity kinase that regulates the spindle assembly check point. Increased expression levels of Mps1…”
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Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases by Suzuki, Naoyuki, Shiota, Takeshi, Watanabe, Fumihiko, Haga, Norihiro, Murashi, Takami, Ohara, Takafumi, Matsuo, Kenji, Omori, Naoki, Yari, Hiroshi, Dohi, Keiji, Inoue, Makiko, Iguchi, Motofumi, Sentou, Jyunko, Wada, Tooru

“…5-Alkenyl or 5-alkynyl-4-anilinopyrimidines were prepared and evaluated for in vitro inhibition of EGFR/Her-2 kinase activity and the growth of tumor cell…”
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S‐222611, an oral reversible tyrosine kinase inhibitor of EGFR and HER2. A representative histological image of the colon treated with S‐222611 (25 mg/kg) by Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka

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Detailed analysis of the δ-crystallin mRNA-expressing region in early development of the chick pituitary gland by Inoue, Makiko, Shiina, Tomoya, Aizawa, Sayaka, Sakata, Ichiro, Takagi, Hiroyasu, Sakai, Takafumi

“…Although δ-crystallin (δ-crys), also known as lens protein, is transiently expressed in Rathke’s pouch (RP) of the chick embryo, detailed temporal and spatial…”
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Detailed analysis of the [delta]-crystallin mRNA-expressing region in early development of the chick pituitary gland by Inoue, Makiko, Shiina, Tomoya, Aizawa, Sayaka, Sakata, Ichiro, Takagi, Hiroyasu, Sakai, Takafumi

“…Although δ-crystallin (δ-crys), also known as lens protein, is transiently expressed in Rathke's pouch (RP) of the chick embryo, detailed temporal and spatial…”
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