Search Results - "Inoue, Ikuyo"

Epilepsy protein Efhc1/myoclonin1 is expressed in cells with motile cilia but not in neurons or mitotic apparatuses in brain by Suzuki, Toshimitsu, Inoue, Ikuyo, Yamakawa, Kazuhiro

“…EFHC1 gene encodes the myoclonin1 protein, also known as Rib72-1. Pathogenic variants in EFHC1 have been reported in patients with juvenile myoclonic epilepsy…”
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Scn1a -GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons by Yamagata, Tetsushi, Ogiwara, Ikuo, Tatsukawa, Tetsuya, Suzuki, Toshimitsu, Otsuka, Yuka, Imaeda, Nao, Mazaki, Emi, Inoue, Ikuyo, Tokonami, Natsuko, Hibi, Yurina, Itohara, Shigeyoshi, Yamakawa, Kazuhiro

“…Expressions of voltage-gated sodium channels Nav1.1 and Nav1.2, encoded by and genes, respectively, have been reported to be mutually exclusive in most brain…”
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TDP-43 accelerates age-dependent degeneration of interneurons by Tsuiji, Hitomi, Inoue, Ikuyo, Takeuchi, Mari, Furuya, Asako, Yamakage, Yuko, Watanabe, Seiji, Koike, Masato, Hattori, Mitsuharu, Yamanaka, Koji

“…TDP-43 is an RNA-binding protein important for many aspects of RNA metabolism. Abnormal accumulation of TDP-43 in the cytoplasm of affected neurons is a…”
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Latency-associated Peptide Degradation Fragments Produced in Stellate Cells and Phagocytosed by Macrophages in Bile Duct-ligated Mouse Liver by Inoue, Ikuyo, Qin, Xian-Yang, Masaki, Takahiro, Mezaki, Yoshihiro, Matsuura, Tomokazu, Kojima, Soichi, Furutani, Yutaka

“…Transforming growth factor-β (TGF-β) activation is involved in various pathogeneses, such as fibrosis and malignancy. We previously showed that TGF-β was…”
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Induction of inverted morphology in brain organoids by vertical-mixing bioreactors by Suong, Dang Ngoc Anh, Imamura, Keiko, Inoue, Ikuyo, Kabai, Ryotaro, Sakamoto, Satoko, Okumura, Tatsuya, Kato, Yoshikazu, Kondo, Takayuki, Yada, Yuichiro, Klein, William L., Watanabe, Akira, Inoue, Haruhisa

“…Organoid technology provides an opportunity to generate brain-like structures by recapitulating developmental steps in the manner of self-organization. Here we…”
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Increased lipid peroxidation in Down's syndrome mouse models by Ishihara, Keiichi, Amano, Kenji, Takaki, Eiichi, Ebrahim, Abdul Shukkur, Shimohata, Atsushi, Shibazaki, Noriko, Inoue, Ikuyo, Takaki, Mayuko, Ueda, Yuto, Sago, Haruhiko, Epstein, Charles J, Yamakawa, Kazuhiro

“…Elevated oxidative stress has been suggested to be associated with the features of Down's syndrome (DS). We previously reported increased oxidative stress in…”
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Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes by Qin, Xian-Yang, Hara, Mitsuko, Arner, Erik, Kawaguchi, Yoshikuni, Inoue, Ikuyo, Tatsukawa, Hideki, Furutani, Yutaka, Nagatsuma, Keisuke, Matsuura, Tomokazu, Wei, Feifei, Kikuchi, Jun, Sone, Hideko, Daub, Carsten, Kawaji, Hideya, Lassmann, Timo, Itoh, Masayoshi, Suzuki, Harukazu, Carninci, Piero, Hayashizaki, Yoshihide, Kokudo, Norihiro, Forrest, Alistair R.R., Kojima, Soichi

“…The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully…”
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Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease by Yokoyama, Hiroshi, Masaki, Takahiro, Inoue, Ikuyo, Nakamura, Mariko, Mezaki, Yoshihiro, Saeki, Chisato, Oikawa, Tsunekazu, Saruta, Masayuki, Takahashi, Hiroyuki, Ikegami, Masahiro, Hano, Hiroshi, Ikejima, Kenichi, Kojima, Soichi, Matsuura, Tomokazu

“…Transforming growth factor-β (TGF-β) is a key driver for liver fibrogenesis. TGF-β must be activated in order to function. Plasma kallikrein (PLK) is a TGF-β…”
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Surmounting Chemoresistance by Targeting the Y-Box Binding Protein-1 by Inoue, Ikuyo, Matsumoto, Ken, Yu, Yingnan, Bay, Boon-Huat

“…The Y‐box binding protein 1 (YB‐1), characterized by the presence of the cold shock domain, has been reported to induce chemoresistance in cancer therapy…”
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Analysis of voltage-gated sodium channel α1 expression using BAC transgenic mice by Ogiwara, Ikuo, Tokonami, Natsuko, Mazaki, Emi, Inoue, Ikuyo, Itohara, Shigeyoshi, Yamakawa, Kazuhiro

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Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid by Qin, Xian-Yang, Suzuki, Harukazu, Honda, Masao, Okada, Hikari, Kaneko, Shuichi, Inoue, Ikuyo, Ebisui, Etsuko, Hashimoto, Kosuke, Carninci, Piero, Kanki, Keita, Tatsukawa, Hideki, Ishibashi, Naoto, Masaki, Takahiro, Matsuura, Tomokazu, Kagechika, Hiroyuki, Toriguchi, Kan, Hatano, Etsuro, Shirakami, Yohei, Shiota, Goshi, Shimizu, Masahito, Moriwaki, Hisataka, Kojima, Soichi

“…Hepatocellular carcinoma (HCC) is a highly lethal cancer that has a high rate of recurrence, in part because of cancer stem cell (CSC)-dependent field…”
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Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation by Ogiwara, Ikuo, Miyamoto, Hiroyuki, Morita, Noriyuki, Atapour, Nafiseh, Mazaki, Emi, Inoue, Ikuyo, Takeuchi, Tamaki, Itohara, Shigeyoshi, Yanagawa, Yuchio, Obata, Kunihiko, Furuichi, Teiichi, Hensch, Takao K, Yamakawa, Kazuhiro

“…Loss-of-function mutations in human SCN1A gene encoding Nav1.1 are associated with a severe epileptic disorder known as severe myoclonic epilepsy in infancy…”
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A Transgenic Pig Model With Human Mutant SOD1 Exhibits the Early Pathology of Amyotrophic Lateral Sclerosis by Kondo, Takayuki, Inoue, Ikuyo, Umeyama, Kazuhiro, Watanabe, Masahito, Matsunari, Hitomi, Uchikura, Ayuko, Nakano, Kazuaki, Tsukita, Kayoko, Imamura, Keiko, Nagashima, Hiroshi, Inoue, Haruhisa

“…Amyotrophic lateral sclerosis (ALS) causes progressive degeneration of the motor neurons. In this study, we delivered the genetic construct including the whole…”
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Simple derivation of skeletal muscle from human pluripotent stem cells using temperature‐sensitive Sendai virus vector by Tan, Ghee Wan, Kondo, Takayuki, Imamura, Keiko, Suga, Mika, Enami, Takako, Nagahashi, Ayako, Tsukita, Kayoko, Inoue, Ikuyo, Kawaguchi, Jitsutaro, Shu, Tsugumine, Inoue, Haruhisa

“…Human pluripotent stem cells have the potential to differentiate into various cell types including skeletal muscles (SkM), and they are applied to regenerative…”
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Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β by Li, Mengqian, Qin, Xian-Yang, Furutani, Yutaka, Inoue, Ikuyo, Sekihara, Sanae, Kagechika, Hiroyuki, Kojima, Soichi

“…Acute liver injury (ALI) is highly lethal acute liver failure caused by different etiologies. Transforming growth factor β (TGF-β) is a multifunctional…”
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Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction by Otsuka, Yuki, Imamura, Keiko, Oishi, Akio, Asakawa, Kazuhide, Kondo, Takayuki, Nakai, Risako, Suga, Mika, Inoue, Ikuyo, Sagara, Yukako, Tsukita, Kayoko, Teranaka, Kaori, Nishimura, Yu, Watanabe, Akira, Umeyama, Kazuhiro, Okushima, Nanako, Mitani, Kohnosuke, Nagashima, Hiroshi, Kawakami, Koichi, Muguruma, Keiko, Tsujikawa, Akitaka, Inoue, Haruhisa

“…Inherited retinal dystrophies (IRDs) are progressive diseases leading to vision loss. Mutation in the eyes shut homolog (EYS) gene is one of the most frequent…”
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Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility by Suzuki, Toshimitsu, Miyamoto, Hiroyuki, Nakahari, Takashi, Inoue, Ikuyo, Suemoto, Takahiro, Jiang, Bin, Hirota, Yuki, Itohara, Shigeyoshi, Saido, Takaomi C., Tsumoto, Tadaharu, Sawamoto, Kazunobu, Hensch, Takao K., Delgado-Escueta, Antonio V., Yamakawa, Kazuhiro

“…Mutations in EFHC1 gene have been previously reported in patients with epilepsies, including those with juvenile myoclonic epilepsy. Myoclonin1, also known as…”
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SCN1A Mutation Mosaicism in a Family with Severe Myoclonic Epilepsy in Infancy by Morimoto, Masafumi, Mazaki, Emi, Nishimura, Akira, Chiyonobu, Tomohiro, Sawai, Yasuko, Murakami, Aki, Nakamura, Keiko, Inoue, Ikuyo, Ogiwara, Ikuo, Sugimoto, Tohru, Yamakawa, Kazuhiro

“…Purpose: To investigate the genetic background of familial severe myoclonic epilepsy in infancy (SMEI) cases. Methods: We performed mutation analyses of the…”
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No visible abnormality of migrating neurons in Efhc1-deficient mouse, a model for juvenile myoclonic epilespy by Yamakawa, Kazuhiro, Suzuki, Toshimitsu, Inoue, Ikuyo

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L(59) TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice by Hara, Mitsuko, Inoue, Ikuyo, Yamazaki, Yuta, Kirita, Akiko, Matsuura, Tomokazu, Friedman, Scott L, Rifkin, Daniel B, Kojima, Soichi

“…Hepatic fibrosis, which is the excessive accumulation of extracellular matrices (ECMs) produced mainly from activated hepatic stellate cells (HSCs), develops…”
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