Search Results - "Innthaler, Bernd"

Biophysical Characterization of Adeno-Associated Virus Vectors Using Ion-Exchange Chromatography Coupled to Light Scattering Detectors by Wagner, Christina, Innthaler, Bernd, Lemmerer, Martin, Pletzenauer, Robert, Birner-Gruenberger, Ruth

“…Ion-exchange chromatography coupled to light scattering detectors represents a fast and simple analytical method for the assessment of multiple critical…”
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Quantification of Empty, Partially Filled and Full Adeno-Associated Virus Vectors Using Mass Photometry by Wagner, Christina, Fuchsberger, Felix F, Innthaler, Bernd, Lemmerer, Martin, Birner-Gruenberger, Ruth

“…Adeno-associated viruses (AAV) are one of the most commonly used vehicles in gene therapies for the treatment of rare diseases. During the AAV manufacturing…”
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Automated Mass Photometry of Adeno-Associated Virus Vectors from Crude Cell Extracts by Wagner, Christina, Fuchsberger, Felix F, Innthaler, Bernd, Pachlinger, Robert, Schrenk, Irene, Lemmerer, Martin, Birner-Gruenberger, Ruth

“…Mass photometry (MP) is a fast and simple analysis method for the determination of the proportions of subpopulations in an AAV sample. It is label-free and…”
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Orthogonal characterization of rAAV9 reveals unexpected transgene heterogeneity by Eisenhut, Peter, Andorfer, Peter, Haid, Andrea, Jokl, Beatrice, Manhartsberger, Raffaela, Fuchsberger, Felix, Innthaler, Bernd, Lengler, Johannes, Kraus, Barbara, Pletzenauer, Robert, Hernandez Bort, Juan A., Unterthurner, Sabine

“…Recombinant adeno-associated virus (rAAV) is the most widely used viral vector for in vivo human gene therapy. To ensure safety and efficacy of gene therapy…”
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Cas‐CLOVER‐mediated knockout of STAT1: A novel approach to engineer packaging HEK‐293 cell lines used for rAAV production by Andorfer, Peter, Kahlig, Carolin‐Isabel, Pakusic, Doris, Pachlinger, Robert, John, Christiane, Schrenk, Irene, Eisenhut, Peter, Lengler, Johannes, Innthaler, Bernd, Micutkova, Lucia, Kraus, Barbara, Brizzee, Corey, Crawford, Jack, Hernandez Bort, Juan A.

“…In addressing the limitations of CRISPR‐Cas9, including off‐target effects and high licensing fees for commercial use, Cas‐CLOVER, a dimeric gene editing tool…”
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