Search Results - "Innis, R.B"

Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra by Innis, R B, Aghajanian, G K

“…Rat substantia nigra was injected with 1 microgram of purified pertussis toxin, a substance which inactivates the inhibitory guanine nucleotide regulatory unit…”
Get more information

Reduced cannabinoid [CB.sub.1] receptor binding in alcohol dependence measured with positron emission tomography by Hirvonen, J, Zanotti-Fregonara, P, Umhau, J.C, George, D.T, Rallis-Frutos, D, Lyoo, C.H, L.I., C.-T, Hines, C.S, Sun, H, Terry, G.E, Morse, C, Zoghbi, S.S, Pike, V.W, Innis, R.B, Heilig, M

“…Brain cannabinoid [CB.sub.1] receptors contribute to alcohol-related behaviors in experimental animals, but their potential role in humans with alcohol…”
Get full text

Reversible and regionally selective downregulation of brain cannabinoid [CB.sub.1] receptors in chronic daily cannabis smokers by Hirvonen, J, Goodwin, R.S, Li, C.-T, Terry, G.E, Zoghbi, S.S, Morse, C, Pike, V.W, Volkow, N.D, Huestis, M.A, Innis, R.B

“…Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies show reversible downregulation of brain cannabinoid [CB.sub.1]…”
Get full text

SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophrenia by Laruelle, M., Abi-Dargham, A., Gil, R., van Dyck, C.H., Erdos, J., D'Souza, D., Rosenblatt, W., McCance-Katz, E., Zea-Ponce, Y., Zoghbi, S.S., Baldwin, R.M., Hoffer, P.B., Krystal, J., Charney, D.S., Innis, R.B.

Get full text

Evaluation of [ 18F]SL702 as a prospective agonist PET radioligand for brain 5-HT 1A receptors in mice and monkey by Lu, Shuiyu, Liow, J.S., Zoghbi, S.S., Gladding, R.L., Innis, R.B., Pike, V.W.

Get full text

Receptor binding characterization of the benzodiazepine radioligand 125I-Ro16-0154: potential probe for SPECT brain imaging by Johnson, E W, Woods, S W, Zoghbi, S, McBride, B J, Baldwin, R M, Innis, R B

“…The binding of an iodinated benzodiazepine (BZ) radioligand has been characterized, particularly in regard to its potential use as a neuroreceptor brain…”
Get more information

[11C]N-desmethyl-loperamide, a substrate that selectively images P-glycoprotein function, is trapped in lysosomes by Kannan, P., Brimacombe, K.R., Zoghbi, S.S., Liow, J.-S., Morse, C., Taku, A., Telu, S., Pike, V.W., Halldin, C., Gottesman, M.M., Hall, M.D., Innis, R.B.

“…The selectivity of dLop was measured as the accumulation of [3H]dLop in three pairs of human cell lines that over-express P-gp, MRP1, or BCRP. Since in vitro…”
Get full text

Pharmacological characterization of the interactions of 2-methoxy-N-propylnorapomorphine (MNPA) with D2 and D3 dopamine receptors by Skinbjerg, Mette, Namkung, Y., Halldin, C., Innis, R.B., Sibley, D.R.

“…Membrane saturation binding on the D2 receptors with [3H]MNPA and [3H]NPA showed a significant decrease in Bmax and an increase in Kd in the presence of…”
Get full text

Pharmacological characterization of the interactions of 2-methoxy- N-propylnorapomorphine (MNPA) with D 2 and D 3 dopamine receptors by Skinbjerg, Mette, Namkung, Y., Halldin, C., Innis, R.B., Sibley, D.R.

Get full text

Inhibition of metabolism of [ 11C]Loperamide in mouse by the potent CYP3A4 inhibitor, ketoconazole by Seneca, Nicholas, Zoghbi, S.S., Tuan, E., Kannan, P., Innis, R.B., Pike, V.W.

“…Results Pretreatment of mice with ketoconazole increased the brain concentrations of [11C]Lop and [11C]N-desmethyl-loperamide about two-fold in KO mice, but…”
Get full text

Effect of the P-gp modulator, cyclosporin-A, on the disposition of the 5-HT 1A receptor radioligand [ 11C](−)-RWAY in rodent brain and blood by Liow, Jeih-San, Lu, S., McCarron, J.A., Hong, J., Pike, V.W., Innis, R.B., Zoghbi, S.S.

Get full text

In vivo density and affinity of [ 11C]( R)-rolipram binding to phosphodiesterase 4 in rat measured with and without anesthesia by Abe, Kohji, Zoghbi, S.S., Inoue, O., Itoh, T., Hong, J., Pike, V.W., Innis, R.B., Fujita, M.

“…Furthermore, phosphorylation of PDE4 increases both the enzyme activity and the sensitivity of PDE4 to inhibition by rolipram [1,2], and phosphorylation status…”
Get full text

Kinetic analysis in healthy humans and radiation dosimetry in monkeys of a novel positron emission tomography radioligand, [ 18F]PBR06, to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation by Fujimura, Yota, Zoghbi, S.S., Gladding, R., Simèon, F.G., Taku, A., Pike, V.W., Innis, R.B., Fujita, M.

“…Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain…”
Get full text

Quantification of specific binding in brain and radiation dosimetry of [ 11C]( R)-PK 11195 in rhesus monkey by Fujimura, Yota, Kreisl, W.C., Zoghbi, S.S., Hong, J., Gladding, R.L., Pike, V.W., Innis, R.B., Fujita, M.

“…The objective of this study was to evaluate the utility of [11C](R)-PK 11195 for PET imaging by measuring specific binding in brain and by estimating radiation…”
Get full text

Species Differences in Brain Phosphodiesterase Levels Measured With [ 11C]( R)-Rolipram PET by Fujita, Masahiro, Zoghbi, S.S., Imaizumi, M., Hong, J., Gladding, R.L., Pike, V.W., Innis, R.B.

“…The purpose of this study was to determine whether there are species differences in brain PDE4 levels by measuring distribution volume corrected by plasma free…”
Get full text

Evaluation of [18F]SL702 as a prospective agonist PET radioligand for brain 5-HT1A receptors in mice and monkey by Lu, Shuiyu, Liow, J.S., Zoghbi, S.S., Gladding, R.L., Innis, R.B., Pike, V.W.

“…Methods Binding affinities for brain receptors and transporters were obtained through the National Institute of Mental Health's Psychoactive Drug Screening…”
Get full text

Occupancy of dopamine D2/D3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA by Seneca, Nicholas, Zoghbi, S.S., Skinbjerg, M., Liow, J.S., Hong, J., Sibley, D.R., Pike, V.W., Halldin, C., Innis, R.B.

“…Ex vivo measurements of the percentage of parent and radiometabolites in rat brain after radioligand injection during baseline and dopamine depletion…”
Get full text

Evaluation of an inverse agonist with high affinity for the CB1 receptor, [11C]MePPEP, in rodents and humans by Terry, Garth E., Liow, J.-S., Chernet, E., Zoghbi, S.S., Phebus, L., Lerner, A., Felder, C.C., Tauscher, J., Schaus, J.M., Pike, V.W., Halldin, C., Innis, R.B.

“…Rodents afforded us the opportunity to: use genetic knockouts to test receptor selectivity and susceptibility to transport by P-glycoprotein (P-gp); dose with…”
Get full text

[ 11C] N-Desmethyl-Loperamide is an improved radiotracer for studying brain P-gp function by Zoghbi, Sami S., Liow, J.-S., Lazarova, N., Hong, J., Tuan, E., Gladding, R.L., Innis, R.B., Pike, V.W.

“…[...]we aimed to evaluate [11C]dLop as a new PET radiotracer. Monkey DCPQ treatment increased brain uptake of [11C]dLop. [...]11C]dLop is superior to [11C]Lop…”
Get full text

Decreased neurokinin-1 (Substance P) receptor binding in patients with panic disorder: Positron emission tomography study with [ 18F]SPA-RQ by Fujimura, Yota, Yasuno, F., Farris, A., Liow, J.-S., Geraci, M., Drevets, W., Pine, D., Lerner, A., Hargreaves, R., Burns, D., Morse, C., Pike, V.W., Innis, R.B.

“…Results Doxapram effectively produced panic attacks in 6 of 7 patients with panic disorder but only 2 of 10 healthy subjects…”
Get full text