Search Results - "Innis, R"

Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers by Hirvonen, J, Goodwin, R S, Li, C-T, Terry, G E, Zoghbi, S S, Morse, C, Pike, V W, Volkow, N D, Huestis, M A, Innis, R B

“…Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies show reversible downregulation of brain cannabinoid CB 1 (cannabinoid…”
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Imaging the Function of P‐Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications by Kannan, P, John, C, Zoghbi, S S, Halldin, C, Gottesman, M M, Innis, R B, Hall, M D

“…P‐glycoprotein (P‐gp), an efflux transporter, controls the pharmacokinetics of various compounds under physiological conditions. P‐gp‐mediated drug efflux has…”
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Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography by Hirvonen, J, Zanotti-Fregonara, P, Umhau, J C, George, D T, Rallis-Frutos, D, Lyoo, C H, Li, C-T, Hines, C S, Sun, H, Terry, G E, Morse, C, Zoghbi, S S, Pike, V W, Innis, R B, Heilig, M

“…Brain cannabinoid CB 1 receptors contribute to alcohol-related behaviors in experimental animals, but their potential role in humans with alcohol dependence is…”
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cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor by Fujita, M, Richards, E M, Niciu, M J, Ionescu, D F, Zoghbi, S S, Hong, J, Telu, S, Hines, C S, Pike, V W, Zarate, C A, Innis, R B

“…Basic studies exploring the importance of the cyclic adenosine monophosphate (cAMP) cascade in major depressive disorder (MDD) have noted that the cAMP cascade…”
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Two-step ALD process for non-oxide ceramic deposition: the example of boron nitride by Hossain, Ali, Souvignet, Thomas, Innis, Neil R, Hao, Wenjun, Boisron, Olivier, Florea, Ileana, Xiao, Peng, Sledzinska, Marianna, Journet, Catherine, Marichy, Catherine

“…Atomic layer deposition (ALD) based on polymer-derived ceramics (PDCs) chemistry is used for the fabrication of boron nitride thin films from reaction between…”
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[123I]β-CIT SPECT imaging assessment of the rate of Parkinson's disease progression by MAREK, K, INNIS, R, VAN DYCK, C, FUSSELL, B, EARLY, M, EBERLY, S, OAKES, D, SEIBYL, J

“…[123I]beta-CIT and SPECT imaging of the dopamine transporter is a sensitive biomarker of PD onset and severity. In this study, the authors examine the change…”
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The role of radiotracer imaging in Parkinson disease by RAVINA, B, EIDELBERG, D, GWINN-HARDY, K, MCFARLAND, H, INNIS, R, KATZ, R. G, KIEBURTZ, K, KISH, S. J, LANGE, N, LANGSTON, J. W, MAREK, K, MORIN, L, AHLSKOG, J. E, MOY, C, MURPHY, D, OERTEL, W. H, OLIVER, G, PALESCH, Y, POWERS, W, SEIBYL, J, SETHI, K. D, SHULTS, C. W, SHEEHY, P, ALBIN, R. L, STOESSL, A. J, HOLLOWAY, R, BROOKS, D. J, CARBON, M, DHAWAN, V, FEIGIN, A, FAHN, S, GUTTMAN, M

“…Radiotracer imaging (RTI) of the nigrostriatal dopaminergic system is a widely used but controversial biomarker in Parkinson disease (PD). Here the authors…”
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Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort by Abi-Dargham, Anissa, Gil, Roberto, Krystal, John, Baldwin, Ronald M., Seibyl, John P., Bowers, Malcom, van Dyck, Christopher H., Charney, Dennis S., Innis, Robert B., Laruelle, Marc

“…OBJECTIVE: The authors previously observed an increase in striatal dopamine transmission following amphetamine challenge in 15 untreated patients with…”
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Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report by Bremner, J. Douglas, Randall, Penny, Vermetten, Eric, Staib, Lawrence, Bronen, Richard A., Mazure, Carolyn, Capelli, Sandi, McCarthy, Gregory, Innis, Robert B., Charney, Dennis S.

“…We have previously reported smaller hippocampal volume and deficits in short-term memory in patients with combat-related posttraumatic stress disorder (PTSD)…”
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Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein by Weidner, Lora D, Fung, King Leung, Kannan, Pavitra, Moen, Janna K, Kumar, Jeyan S, Mulder, Jan, Innis, Robert B, Gottesman, Michael M, Hall, Matthew D

“…Since its development, tariquidar (TQR; XR9576;…”
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D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene by LARUELLE, M, GELERNTER, J, INNIS, R. B

“…Alcoholism and substance abuse have been associated with a polymorphism in a noncoding region of the D2 receptor gene (the A1 allele of the Taq1 'A' system) in…”
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Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report by Jacobsen, Leslie K., Staley, Julie K., Zoghbi, Sami S., Seibyl, John P., Kosten, Thomas R., Innis, Robert B., Gelernter, Joel

“…OBJECTIVE: Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes. METHOD: The…”
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Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder by Bremner, J. Douglas, Innis, Robert B., Southwick, Steven M., Staib, Lawrence, Zoghbi, Sami, Charney, Dennis S.

“…OBJECTIVE: Animals exposed to stress exhibit a decrease in benzodiazepine receptor binding in the frontal cortex. No studies have examined central…”
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[123I]β/CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease by MAREK, K. L, SEIBYL, J. P, ZOGHBI, S. S, ZEA-PONCE, Y, BALDWIN, R. M, FUSSELL, B, CHARNEY, D. S, VAN DYCK, C, HOFFER, P. B, INNIS, R. B

“…We have used in vivo single-photon emission computed tomography (SPECT) of the dopamine transporter with 2 beta-carboxymethoxy-3 beta-(4-iodophenyl)tropane…”
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Reduced brain serotonin transporter availability in major depression as measured by [ 123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography by Malison, Robert T, Price, Lawrence H, Berman, Robert, van Dyck, Christopher H, Pelton, Gregory H, Carpenter, Linda, Sanacora, Gerard, Owens, Michael J, Nemeroff, Charles B, Rajeevan, Nallakandi, Baldwin, Robert M, Seibyl, John P, Innis, Robert B, Charney, Dennis S

“…Background: Prior research has suggested reductions in the density of serotonin transporter (SERT) binding sites in blood platelets and post-mortem brain…”
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MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder by Bremner, J D, Randall, P, Scott, T M, Bronen, R A, Seibyl, J P, Southwick, S M, Delaney, R C, McCarthy, G, Charney, D S, Innis, R B

“…Studies in nonhuman primates suggest that high levels of cortisol associated with stress have neurotoxic effects on the hippocampus, a brain structure involved…”
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Single Photon Emission Computerized Tomography Imaging of Amphetamine-Induced Dopamine Release in Drug-Free Schizophrenic Subjects by Laruelle, Marc, Abi-Dargham, Anissa, Van Dyck, Christopher H., Gil, Roberto, D'Souza, Cyril D., Erdos, Joseph, McCance, Elinore, Rosenblatt, William, Fingado, Christine, Zoghbi, Sami S., Baldwin, Ronald M., Seibyl, John P., Krystal, John H., Charney, Dennis S., Innis, Robert B.

“…The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic transmission is associated with this illness, but direct observation of…”
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Molecular Imaging of the Dopaminergic System and its Association with Human Cognitive Function by Cropley, Vanessa L., Fujita, Masahiro, Innis, Robert B., Nathan, Pradeep J.

“…Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) has recently been used to examine dopamine…”
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Brain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients by Anand, Amit, Verhoeff, Paul, Seneca, Nicholas, Zoghbi, Sami S., Seibyl, John P., Charney, Dennis S., Innis, Robert B.

“…OBJECTIVE: Increased dopaminergic neurotransmission has been implicated in the pathophysiology of bipolar disorder. However, it remains unclear whether the…”
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Single Photon Emission Computed Tomographic Imaging Demonstrates Loss of Striatal Dopamine Transporters in Parkinson Disease by Innis, R. B., Seibyl, J. P., Scanley, B. E., Laruelle, M., Abi-Dargham, A., Wallace, E., Baldwin, R. M., Zea-Ponce, Y., Zoghbi, S., Wang, S., Gao, Y., Neumeyer, J. L., Charney, D. S., Hoffer, P. B., Marek, K. L.

“…[123][(1R)-2β-carbomethoxy-3β-(4-iodophenyl)tropane] ([k123I]β-CIT) labels dopamine transporters and is, therefore, a marker of neurons that degenerate in…”
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