Search Results - "Innate immunity (London, England)"

TLRs in COVID-19: How they drive immunopathology and the rationale for modulation by Mabrey, F. Linzee, Morrell, Eric D, Wurfel, Mark M

“…COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive the balance between deleterious…”
Get full text

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways by Kim, Sena, Joe, Yeonsoo, Jeong, Sun Oh, Zheng, Min, Back, Sung Hoon, Park, Sang Won, Ryter, Stefan W, Chung, Hun Taeg

“…The mechanisms underlying pathophysiological states such as metabolic syndrome and obesity include endoplasmic reticulum (ER) stress and aberrant inflammatory…”
Get more information

Campylobacter infection in chickens modulates the intestinal epithelial barrier function by Awad, Wageha A, Molnár, Andor, Aschenbach, Jörg R, Ghareeb, Khaled, Khayal, Basel, Hess, Claudia, Liebhart, Dieter, Dublecz, Károly, Hess, Michael

“…Asymptomatic carriage of Campylobacter jejuni is highly prevalent in chicken flocks. Thus, we investigated whether chronic Campylobacter carriage affects…”
Get more information

Innate lymphoid cells and infectious diseases by Yuan, Ting, Zhou, Qianhui, Tian, Yuqiu, Ou, Yangjing, Long, YunZhu, Tan, YingZheng

“…Innate lymphoid cells (ILCs) are the main resident lymphocytes that mostly reside in tissues owing to the lack of adaptive antigen receptors. These cells are…”
Get full text

A pilot study of monocytes in relapsing remitting multiple sclerosis: Correlation with disease activity by Taha, Sara I, Mohamed, Hala Ghareeb, Mamdouh, Rasha, Kamal, Nada E, Khater, Shaimaa Sayed

“…Background: Numerous immune cells are involved in developing multiple sclerosis (MS). Monocytes are believed to be the first to enter the brain and initiate…”
Get full text

The in vitro effect of myeloperoxidase oxidized LDL on THP-1 derived macrophages by Jeradeh, Elias, Frangie, Christian, Bazzi, Samer, Daher, Jalil

“…Cardiovascular diseases (CVDs) linked to atherosclerosis remains the leading cause of death worldwide. Atherosclerosis is primarily caused by the accumulation…”
Get full text

Selective IgG binding to the LPS glycolipid core found in bovine colostrum, or milk, during Escherichia coli mastitis influences endotoxin function by Hurst, Suzanne M., Flossdorf, David A. L., Koralagamage Don, Raveen, Pernthaner, Anton

“…The dynamic interplay between intramammary IgG, formation of antigen-IgG complexes and effector immune cell function is essential for immune homeostasis within…”
Get full text

CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function by Kirby, Emily N., Montin, Xavier B., Allen, Timothy P., Densumite, Jaslan, Trowbridge, Brooke N., Beard, Michael R.

“…Interferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding…”
Get full text

Myricetin reduces neutrophil extracellular trap release in a rat model of rheumatoid arthritis, which is associated with a decrease in disease severity by Shu, Yiqin, Yang, Rui, Wen, Huijie, Dong, Qiannan, Chen, Zhiqi, Xiang, Yang, Wu, Hao

“…Rheumatoid arthritis (RA) is a chronic disease characterized by joint inflammation and severe disability. However, there is a lack of safe and effective drugs…”
Get full text

Nasal mucosal fibroblasts produce IL-4 to induce Th2 response by Zeng, Xianhai, Li, Juanjuan, Liu, Jiangqi, Mo, Lihua, Liu, Yu, Zhang, Aizhi, Yang, Pingchang, Kong, Hui

“…Th2 polarization is essential for the pathogenesis of allergic rhinitis (AR). Th2 polarization's mechanism requires further understanding. IL-4 is the primary…”
Get full text

The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia by Huang, Jing, Tian, Rui, Yang, Yongqiang, Jiang, Rong, Dai, Jie, Tang, Li, Zhang, Li

“…It is generally regarded that Sirtuin 1 (SIRT1), a longevity factor in mammals, acts as a negative regulator of inflammation. However, recent studies also…”
Get more information

Production of a p65/LysMCre mouse model with dysfunctional NF-κB signaling in bone marrow-derived macrophages by Ahmet K. Korkaya, Jeffrey Fischer, Anthony Peppers, Sean M. Crosson, Manira Rayamajhi, Edward A. Miao, Albert S. Baldwin, Jennifer W. Bradford

“…Here, we describe the production and characterization of a novel p65 fl/fl /LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65…”
Get full text

Production of a p65 fl/fl /LysMCre mouse model with dysfunctional NF-κB signaling in bone marrow-derived macrophages by Korkaya, Ahmet K, Fischer, Jeffrey, Peppers, Anthony, Crosson, Sean M, Rayamajhi, Manira, Miao, Edward A, Baldwin, Jr, Albert S, Bradford, Jennifer W

“…Here, we describe the production and characterization of a novel p65 /LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65…”
Get full text

The TNF-α (–238 G/A) polymorphism could protect against development of severe sepsis by Hugo Montes, A., Valle-Garay, Eulalia, Martin, Guadalupe, Collazos, Julio, Alvarez, Victoria, Meana, Alvaro, Pérez-Is, Laura, Carton, José A., Taboada, Francisco, Asensi, Víctor

“…Primary responses in sepsis-mediated inflammation are regulated by pro-inflammatory cytokines. Variations in the cytokine genes might modify their…”
Get full text

Human NK cells: From development to effector functions by Perera Molligoda Arachchige, Arosh Shavinda

“…NK cells are the major lymphocyte subset of the innate immune system that mediates antiviral and anti-tumor responses. It is well established that they develop…”
Get full text

Recognition of infection by natural killer cells: Towards a complete picture by experimental studies in rats by Hamid Shegarfi

“…The study of cellular immune responses in animal disease models demands detailed knowledge of development, function, and regulation of immune cells, including…”
Get full text

Altered phenotype in peripheral blood and tumor-associated NK cells from colorectal cancer patients by Rocca, Yamila S, Roberti, María P, Arriaga, Juan M, Amat, Mora, Bruno, Luisina, Pampena, María B, Huertas, Eduardo, Loria, Fernando Sánchez, Pairola, Alejandro, Bianchini, Michele, Mordoh, José, Levy, Estrella M

“…Despite NK cells being originally identified because of their ability to kill tumor cells in vitro, only limited information is available on NK cells…”
Get more information

Association between interleukin-27 gene polymorphisms and Malaria by Nada H. Aljarba, Mashael R. Al-Anazi, Tahani M. Al-Hazani, Mohammed I. Shafeai, Fuad H. Rudiny, Ali M. Motaen, Saad M. Bin Dajem, Hani Alothaid, Jahad Alghamdi, Saad Alkahtani, Ahmed A. Al-Qahtani

“…Malaria is often characterized by a complicated disease course due to multifaceted intrinsic genetic factors of the host and the parasite. This study aimed to…”
Get full text

Beneficial effect of probiotics on Pseudomonas aeruginosa–infected intestinal epithelial cells through inflammatory IL-8 and antimicrobial peptide human beta-defensin-2 modulation by Huang, Fu-Chen, Lu, Yi-Ting, Liao, Yu-Hsuan

“…The human pathogen Pseudomonas aeruginosa can rapidly induce fatal sepsis, even in previously healthy infants or children treated with appropriate antibiotics…”
Get full text

Human breast milk-derived exosomes attenuate cell death in intestinal epithelial cells by Martin, Colin, Patel, Mikita, Williams, Sparkle, Arora, Hamish, Sims, Brian

“…Human breast milk has been shown to reduce the incidence of necrotizing enterocolitis (NEC). Breast milk has many components (immunoglobulins, proteins, fat,…”
Get full text