Search Results - "Ingthorsson, Saevar"

ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion by Steinhaeuser, Sophie Sarah, Morera, Erika, Budkova, Zuzana, Schepsky, Alexander, Wang, Qiong, Rolfsson, Ottar, Riedel, Angela, Krueger, Aileen, Hilmarsdottir, Bylgja, Maelandsmo, Gunhild Mari, Valdimarsdottir, Bryndis, Sigurdardottir, Anna Karen, Agnarsson, Bjarni Agnar, Jonasson, Jon Gunnlaugur, Ingthorsson, Saevar, Traustadottir, Gunnhildur Asta, Oskarsson, Thordur, Gudjonsson, Thorarinn

“…The tumor microenvironment is increasingly recognized as key player in cancer progression. Investigating heterotypic interactions between cancer cells and…”
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Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutum by Yi, Zhiqian, Su, Yixi, Xu, Maonian, Bergmann, Andreas, Ingthorsson, Saevar, Rolfsson, Ottar, Salehi-Ashtiani, Kourosh, Brynjolfsson, Sigurdur, Fu, Weiqi

“…Diatoms are a major group of unicellular algae that are rich in lipids and carotenoids. However, sustained research efforts are needed to improve the strain…”
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Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responses by Joelsson, Jon Petur, Kricker, Jennifer A, Arason, Ari J, Sigurdsson, Snaevar, Valdimarsdottir, Bryndis, Gardarsson, Fridrik Runar, Page, Clive P, Lehmann, Fredrik, Gudjonsson, Thorarinn, Ingthorsson, Saevar

“…Abstract Background The airway epithelium (AE) forms the first line of defence against harmful particles and pathogens. Barrier failure of the airway…”
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Ventilator-induced lung-injury in mouse models: Is there a trap? by Joelsson, Jon Petur, Ingthorsson, Saevar, Kricker, Jennifer, Gudjonsson, Thorarinn, Karason, Sigurbergur

“…Abstract Ventilator-induced lung injury (VILI) is a serious acute injury to the lung tissue that can develop during mechanical ventilation of patients. Due to…”
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deltaNp63 has a role in maintaining epithelial integrity in airway epithelium by Arason, Ari Jon, Jonsdottir, Hulda R, Halldorsson, Skarphedinn, Benediktsdottir, Berglind Eva, Bergthorsson, Jon Thor, Ingthorsson, Saevar, Baldursson, Olafur, Sinha, Satrajit, Gudjonsson, Thorarinn, Magnusson, Magnus K

“…The upper airways are lined with a pseudostratified bronchial epithelium that forms a barrier against unwanted substances in breathing air. The transcription…”
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Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia by Arason, Ari Jon, Joelsson, Jon Petur, Valdimarsdottir, Bryndis, Sigurdsson, Snaevar, Gudjonsson, Alexander, Halldorsson, Skarphedinn, Johannsson, Freyr, Rolfsson, Ottar, Lehmann, Fredrik, Ingthorsson, Saevar, Cherek, Paulina, Gudmundsson, Gudmundur H, Gardarsson, Fridrik R, Page, Clive P, Baldursson, Olafur, Gudjonsson, Thorarinn, Kricker, Jennifer A

“…Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear…”
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Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model by Joelsson, Jon Petur, Asbjarnarson, Arni, Sigurdsson, Snaevar, Kricker, Jennifer, Valdimarsdottir, Bryndis, Thorarinsdottir, Holmfridur, Starradottir, Eir, Gudjonsson, Thorarinn, Ingthorsson, Saevar, Karason, Sigurbergur

“…Abstract Background Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas…”
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Evanescent-wave fluorescence microscopy using symmetric planar waveguides by Agnarsson, Bjorn, Ingthorsson, Saevar, Gudjonsson, Thorarinn, Leosson, Kristjan

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Endothelial cells stimulate growth of normal and cancerous breast epithelial cells in 3D culture by Ingthorsson, Saevar, Sigurdsson, Valgardur, Fridriksdottir, Jr, Agla, Jonasson, Jon G, Kjartansson, Jens, Magnusson, Magnus K, Gudjonsson, Thorarinn

“…Epithelial-stromal interaction provides regulatory signals that maintain correct histoarchitecture and homeostasis in the normal breast and facilitates tumor…”
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Expression and functional role of sprouty-2 in breast morphogenesis by Sigurdsson, Valgardur, Ingthorsson, Saevar, Hilmarsdottir, Bylgja, Gustafsdottir, Sigrun M, Franzdottir, Sigridur Rut, Arason, Ari Jon, Steingrimsson, Eirikur, Magnusson, Magnus K, Gudjonsson, Thorarinn

“…Branching morphogenesis is a mechanism used by many species for organogenesis and tissue maintenance. Receptor tyrosine kinases (RTKs), including epidermal…”
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Application of the D492 Cell Lines to Explore Breast Morphogenesis, EMT and Cancer Progression in 3D Culture by Briem, Eirikur, Ingthorsson, Saevar, Traustadottir, Gunnhildur Asta, Hilmarsdottir, Bylgja, Gudjonsson, Thorarinn

“…The human female breast gland is composed of branching epithelial ducts that extend from the nipple towards the terminal duct lobular units (TDLUs), which are…”
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Melflufen, a peptide‐conjugated alkylator, is an efficient anti‐neo‐plastic drug in breast cancer cell lines by Schepsky, Alexander, Traustadottir, Gunnhildur Asta, Joelsson, Jon Petur, Ingthorsson, Sævar, Kricker, Jennifer, Bergthorsson, Jon Thor, Asbjarnarson, Arni, Gudjonsson, Thorkell, Nupponen, Nina, Slipicevic, Ana, Lehmann, Fredrik, Gudjonsson, Thorarinn

“…Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide‐conjugated drug currently in phase 3 trials for the treatment of relapsed or…”
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Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cells by Hilmarsdottir, Bylgja, Briem, Eirikur, Halldorsson, Skarphedinn, Kricker, Jennifer, Ingthorsson, Sævar, Gustafsdottir, Sigrun, Mælandsmo, Gunhild M, Magnusson, Magnus K, Gudjonsson, Thorarinn

“…Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising…”
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Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer Initiation by Ingthorsson, Saevar, Traustadottir, Gunnhildur Asta, Gudjonsson, Thorarinn

“…The human breast gland is a unique organ as most of its development occurs postnatally between menarche and menopause, a period ranging from 30 to 40 years…”
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Epithelial Plasticity During Human Breast Morphogenesis and Cancer Progression by Ingthorsson, Saevar, Briem, Eirikur, Bergthorsson, Jon Thor, Gudjonsson, Thorarinn

“…Understanding the complex events leading to formation of an epithelial-based organ such as the breast requires a detailed insight into the crosstalk between…”
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Evanescent-wave fluorescence microscopy using symmetric planar waveguides by Agnarsson, Björn, Ingthorsson, Saevar, Gudjonsson, Thorarinn, Leosson, Kristjan

“…We describe a new evanescent-wave fluorescence excitation method, ideally suited for imaging of biological samples. The excitation light propagates in a planar…”
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Abstract 5205: Melflufen, a peptide-conjugated alkylator, shows efficacy in breast cancer cell lines by Schepsky, Alexander, Traustadottir, Gunnhildur A., Joelsson, Jon Petur, Ingthorsson, Saevar, Kricker, Jennifer, Bergthyorsson, Jon T., Petursdottir, Katrina B., Gudjonsson, Thorkell, Slipicevic, Ana, Lehmann, Fredrik, Gudjonsson, Thorarinn

“…Abstract Introduction: Melflufen is a lipophilic peptide-conjugated alkylator currently in phase 3 trial for the treatment of late stage multiple myeloma. Due…”
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Abstract 3435: Profiling miRNAs in breast epithelial progenitor cells during branching morphogenesis and EMT in 3D culture by Briem, Eirikur, Hilmarsdottir, Bylgja, Budkova, Zuzana, Ingthorsson, Saevar, Magnusson, Magnus K., Gudjonsson, Thorarinn

“…Abstract In this study we investigate the role of miRNA-203a in branching morphogenesis and epithelial to mesenchymal transition (EMT) in breast cell lines…”
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Pathological changes in basement membranes and dermal connective tissue of skin from patients with hereditary cystatin C amyloid angiopathy by Snorradottir, Asbjorg Osk, Isaksson, Helgi J, Ingthorsson, Saevar, Olafsson, Elias, Palsdottir, Astridur, Bragason, Birkir Thor

“…Hereditary cystatin C amyloid angiopathy (HCCAA) is a genetic disease caused by a mutation in the cystatin C gene. Cystatin C is abundant in cerebrospinal…”
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YKL-40/CHI3L1 facilitates migration and invasion in HER2 overexpressing breast epithelial progenitor cells and generates a niche for capillary-like network formation by Morera, Erika, Steinhäuser, Sarah Sophie, Budkova, Zuzana, Ingthorsson, Saevar, Kricker, Jennifer, Krueger, Aileen, Traustadottir, Gunnhildur Asta, Gudjonsson, Thorarinn

“…Epithelial to mesenchymal transition (EMT) is a developmental event that is hijacked in some diseases such as fibrosis and cancer. In cancer, EMT has been…”
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