Search Results - "Ingle, Kevin A."

Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology by Halade, Ganesh V, Kain, Vasundhara, Ingle, Kevin A

“…Heart failure (HF) secondary to myocardial infarction (MI) is linked to kidney complications that comprise cellular, structural, functional, and survival…”
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Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing by Kain, Vasundhara, Liu, Fei, Kozlovskaya, Veronika, Ingle, Kevin. A., Bolisetty, Subhashini, Agarwal, Anupam, Khedkar, Santosh, Prabhu, Sumanth D., Kharlampieva, Eugenia, Halade, Ganesh V.

“…Following myocardial infarction (MI), overactive inflammation remodels the left ventricle (LV) leading to heart failure coinciding with reduced levels of…”
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Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation by Ingle, Kevin A, Kain, Vasundhara, Goel, Mehak, Prabhu, Sumanth D, Young, Martin E, Halade, Ganesh V

“…The mammalian circadian clock consists of multiple transcriptional regulators that coordinate biological processes in a time-of-day-dependent manner…”
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Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function by Kain, Vasundhara, Ingle, Kevin A, Colas, Romain A, Dalli, Jesmond, Prabhu, Sumanth D, Serhan, Charles N, Joshi, Medha, Halade, Ganesh V

“…Abstract Unresolved inflammation is a major contributor to the development of heart failure following myocardial infarction (MI). Pro-resolving lipid…”
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Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing by Halade, Ganesh V, Kain, Vasundhara, Ingle, Kevin A, Prabhu, Sumanth D

“…The metabolic transformation of fatty acids to form oxylipids using 12/15-lipoxygenase (LOX) can promote either resolving or nonresolving inflammation…”
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Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction by Halade, Ganesh V, Kain, Vasundhara, Black, Laurence M, Prabhu, Sumanth D, Ingle, Kevin A

“…Post-myocardial infarction (MI), overactive inflammation is the hallmark of aging, however, the mechanism is unclear. We hypothesized that excess influx of…”
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Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation by Kain, Vasundhara, Ingle, Kevin A, Kachman, Maureen, Baum, Heidi, Shanmugam, Gobinath, Rajasekaran, Namakkal S, Young, Martin E, Halade, Ganesh V

“…Maintaining a balance of ω-6 and ω-3 fatty acids is essential for cardiac health. Current ω-6 and ω-3 fatty acids in the American diet have shifted from the…”
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Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction by Kain, Vasundhara, Ingle, Kevin A., Kabarowski, Janusz, Barnes, Stephen, Limdi, Nita A., Prabhu, Sumanth D., Halade, Ganesh V.

“…12/15 lipoxygenase (LOX) directs inflammation and lipid remodeling. However, the role of 12/15LOX in post-myocardial infarction (MI) left ventricular…”
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Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction by Lopez, Elizabeth F, Kabarowski, Janusz H, Ingle, Kevin A, Kain, Vasundhara, Barnes, Stephen, Crossman, David K, Lindsey, Merry L, Halade, Ganesh V

“…Polyunsaturated fatty acid (PUFA) intake has increased over the last 100 yr, contributing to the current obesogenic environment. Obesity and aging are…”
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Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart by Halade, Ganesh V., Dorbane, Anela, Ingle, Kevin A., Kain, Vasundhara, Schmitter, Jean-Marie, Rhourri-Frih, Boutayna

“…Myocardial infarction (MI) and subsequent progressive heart failure pathology is the major cause of death worldwide; however, the mechanism of this pathology…”
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Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice by Kain, Vasundhara, Ingle, Kevin A, Rajasekaran, Namakkal S, Halade, Ganesh V

“…Immune responsive 12/15 lipoxygenase (12/15LOX)-orchestrate biosynthesis of essential inflammation-resolution mediators during acute inflammatory response in…”
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Cardiac Tissue Chip Model of Arteriovenous Fistula-Associated Hemodynamics Recapitulates Changes Seen in Mouse AVF Model: TH-PO301 by Lee, Timmy C., Waldrop, Tatyana Isayeva, Graham, Caleb, Gard, William A., Ingle, Kevin A., Sethu, Palaniappan

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Influence of Hemodynamic Changes on Venous Endothelial Cell Adaptation After Arteriovenous Fistula Creation: TH-PO302 by Lewis, Taylor G., Waldrop, Tatyana Isayeva, Somarathna, Maheshika S., Ingle, Kevin A., Lee, Timmy C.

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Deficient Endothelial Autophagy Promotes Accelerated Atherosclerosis and Impaired Arteriovenous Fistula (AVF) Remodeling: FR-PO487 by Collie, Paul C., Ingle, Kevin A., Waldrop, Tatyana Isayeva, Gard, William A., Kim, Jeonga, Lee, Timmy C.

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Autophagy Response and Arteriovenous Fistula Maturation: PO1012 by Waldrop, Tatyana Isayeva, Somarathna, Maheshika S., Ingle, Kevin A., Lee, Timmy C.

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Inhibition of Phosphodiesterase Type 5A Prevents Pathological Cardiac Remodeling Following Arteriovenous Fistula Creation: PO1016 by Somarathna, Maheshika S., Lewis, Taylor G., Ingle, Kevin A., Waldrop, Tatyana Isayeva, Lee, Timmy C.

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Nitric Oxide-Releasing Nanomatrix Gel Inhibits Venous Intimal Hyperplasia and Improves Vascular Remodeling in Porcine Arteriovenous Fistula (AVF): FR-PO464 by Nguyen, Nguyen T., Ingle, Kevin A., Waldrop, Tatyana Isayeva, Lose, Bailey G., Collie, Paul C., Gard, William A., Hwang, Patrick, Jun, Ho-Wook, Northrup, Hannah M., Shiu, Yan-Ting E., Lee, Timmy C.

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Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart: Anal Bioanal Chem by Halade, Ganesh V., Dorbane, Anela, Ingle, Kevin A., Kain, Vasundhara, Schmitter, Jean-Marie, Rhourri-Frih, Boutayna

“…Myocardial infarction (MI) and subsequent progressive heart failure pathology is the major cause of death worldwide; however, the mechanism of this pathology…”
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Resolvin D1 Programs Myocardial Infarction‐induced Cardiorenal Syndrome in Heart Failure Pathology by Halade, Ganesh V., Kain, Vasundhara, Serhan, Charles N., Ingle, Kevin A.

“…Abstract only Resolvins are innate immune responsive lipid mediators produced after myocardial infarction (MI) to resolve inflammation. MI‐induced…”
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Abstract 13276: DHA but not Etanercept Expedites Resolution of Inflammation leading to Improved Survival Following Myocardial Infarction in Aging Mice by Ingle, Kevin A, Kain, Vasundhara, Halade, Ganesh V

“…Abstract only Dietary intake of n-3 polyunsaturated fatty acids (PUFA) has been touted for cardioprotective benefits. n-3 PUFA contains docosahexaenoic acid…”
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