Search Results - "Ingemarsdotter, Carin K"

Optimization of a lentivirus-mediated gene therapy targeting HIV-1 RNA to eliminate HIV-1-infected cells by Buckingham, Amanda B., Ho, Sophia, Knops-Mckim, Finlay, Ingemarsdotter, Carin K., Lever, Andrew M.L.

“…Persistence of HIV-1 in cellular reservoirs results in lifelong infection, with cure achieved only in rare cases through ablation of marrow-derived cells. We…”
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A scale-free analysis of the HIV-1 genome demonstrates multiple conserved regions of structural and functional importance by Skittrall, Jordan P, Ingemarsdotter, Carin K, Gog, Julia R, Lever, Andrew M L

“…HIV-1 replicates via a low-fidelity polymerase with a high mutation rate; strong conservation of individual nucleotides is highly indicative of the presence of…”
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An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation by Ingemarsdotter, Carin K, Zeng, Jingwei, Long, Ziqi, Lever, Andrew M L, Kenyon, Julia C

“…NSC260594, a quinolinium derivative from the NCI diversity set II compound library, was previously identified in a target-based assay as an inhibitor of the…”
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RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer by Tookman, Laura A, Browne, Ashley K, Connell, Claire M, Bridge, Gemma, Ingemarsdotter, Carin K, Dowson, Suzanne, Shibata, Atsushi, Lockley, Michelle, Martin, Sarah A, McNeish, Iain A

“…Homologous recombination (HR) function is critically important in high-grade serous ovarian cancer (HGSOC). HGSOC with intact HR has a worse prognosis and is…”
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Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells by Ingemarsdotter, Carin K., Poddar, Sushmita, Mercier, Sarah, Patzel, Volker, Lever, Andrew M.L.

“…Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can…”
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Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control by Ingemarsdotter, Carin K., Tookman, Laura A., Browne, Ashley, Pirlo, Katrina, Cutts, Rosalind, Chelela, Claude, Khurrum, Karisma F., Leung, Elaine Y.L., Dowson, Suzanne, Webber, Lee, Khan, Iftekhar, Ennis, Darren, Syed, Nelofer, Crook, Tim R., Brenton, James D., Lockley, Michelle, McNeish, Iain A.

“…Resistance to paclitaxel chemotherapy frequently develops in ovarian cancer. Oncolytic adenoviruses are a novel therapy for human malignancies that are being…”
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Therapeutic applications of trans-splicing by Hong, Elizabeth M, Ingemarsdotter, Carin K, Lever, Andrew M L

“…RNA trans-splicing joins exons from different pre-mRNA transcripts to generate a chimeric product. Trans-splicing can also occur at the protein level, with…”
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Duplex formation between the template and the nascent strand in the transcription-regulating sequences is associated with the site of template switching in SARS - CoV-2 by D'Souza, Aaron R., Buckingham, Amanda B., Salasc, Fanny, Ingemarsdotter, Carin K., Iaconis, Gennaro, Jarvis, Isobel, Groom, Harriet C. T., Kenyon, Julia C., Lever, Andrew M. L.

“…Recently published transcriptomic data of the SARS-CoV-2 coronavirus show that there is a large variation in the frequency and steady state levels of…”
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Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity by Browne, Ashley, Tookman, Laura A, Ingemarsdotter, Carin K, Bouwman, Russell D, Pirlo, Katrina, Wang, Yaohe, McNeish, Iain A, Lockley, Michelle

“…Adenoviruses have been clinically tested as anticancer therapies but their utility has been severely limited by rapid, systemic cytokine release and consequent…”
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Inhibition of the Inflammatory Cytokine TNF-α Increases Adenovirus Activity in Ovarian Cancer via Modulation of cIAP1/2 Expression by Salako, Michael A, Kulbe, Hagen, Ingemarsdotter, Carin K, Pirlo, Katrina J, Williams, Sarah L, Lockley, Michelle, Balkwill, Frances R, McNeish, Iain A

“…Oncolytic adenoviruses show promise as a cancer treatment. However, they generate acute inflammatory responses with production of cytokines, including tumor…”
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Inhibition of the Inflammatory Cytokine TNF-[alpha] Increases Adenovirus Activity in Ovarian Cancer via Modulation of cIAP1/2 Expression by Salako, Michael A, Kulbe, Hagen, Ingemarsdotter, Carin K, Pirlo, Katrina J, Williams, Sarah L, Lockley, Michelle, Balkwill, Frances R, Mcneish, Iain A

“…Oncolytic adenoviruses show promise as a cancer treatment. However, they generate acute inflammatory responses with production of cytokines, including tumor…”
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