Search Results - "Ingelsson Erik"

5 year mortality predictors in 498 103 UK Biobank participants: a prospective population-based study by Ganna, Andrea, PhD, Ingelsson, Erik, Prof

“…Summary Background To our knowledge, a systematic comparison of predictors of mortality in middle-aged to elderly individuals has not yet been done. We…”
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Genome-wide association studies of obesity and metabolic syndrome by Fall, Tove, Ingelsson, Erik

“…• GWAS have greatly increased the knowledge about obesity genetics. • Common forms of obesity are polygenic with small effects sizes of each variant. • The…”
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Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis by Flores, Alyssa M., Hosseini-Nassab, Niloufar, Jarr, Kai-Uwe, Ye, Jianqin, Zhu, Xingjun, Wirka, Robert, Koh, Ai Leen, Tsantilas, Pavlos, Wang, Ying, Nanda, Vivek, Kojima, Yoko, Zeng, Yitian, Lotfi, Mozhgan, Sinclair, Robert, Weissman, Irving L., Ingelsson, Erik, Smith, Bryan Ronain, Leeper, Nicholas J.

“…Atherosclerosis is the process that underlies heart attack and stroke. A characteristic feature of the atherosclerotic plaque is the accumulation of apoptotic…”
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A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections by Tängdén, Thomas, Gustafsson, Stefan, Rao, Abhiram S., Ingelsson, Erik

“…There is limited data on host-specific genetic determinants of susceptibility to bacterial and viral infections. Genome-wide association studies using large…”
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Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study by Lankester, Joanna, Zanetti, Daniela, Ingelsson, Erik, Assimes, Themistocles L

“…Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes…”
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Fatty Liver Index and Development of Cardiovascular Disease: Findings from the UK Biobank by Zou, Biyao, Yeo, Yee Hui, Cheung, Ramsey, Ingelsson, Erik, Nguyen, Mindie H.

“…Background Nonalcoholic fatty liver disease is common and is associated with rising morbidity and mortality in the UK. Cardiovascular disease is the main cause…”
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Impact of Body Mass Index and the Metabolic Syndrome on the Risk of Cardiovascular Disease and Death in Middle-Aged Men by ÄRNLÖV, Johan, INGELSSON, Erik, SUNDSTRÖM, Johan, LIND, Lars

“…The purpose of this study was to investigate associations between combinations of body mass index (BMI) categories and metabolic syndrome (MetS) and the risk…”
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Development and validation of risk prediction models for multiple cardiovascular diseases and Type 2 diabetes by Rezaee, Mehrdad, Putrenko, Igor, Takeh, Arsia, Ganna, Andrea, Ingelsson, Erik

“…Accurate risk assessment of an individuals' propensity to develop cardiovascular diseases (CVDs) is crucial for the prevention of these conditions. Numerous…”
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Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts by Nowak, Christoph, Sundström, Johan, Gustafsson, Stefan, Giedraitis, Vilmantas, Lind, Lars, Ingelsson, Erik, Fall, Tove

“…Insulin resistance (IR) is a precursor of type 2 diabetes (T2D), and improved risk prediction and understanding of the pathogenesis are needed. We used a novel…”
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Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank by Tikkanen, Emmi, Gustafsson, Stefan, Amar, David, Shcherbina, Anna, Waggott, Daryl, Ashley, Euan A., Ingelsson, Erik

“…We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology…”
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Genome-wide association study of toxic metals and trace elements reveals novel associations by Ng, Esther, Lind, P Monica, Lindgren, Cecilia, Ingelsson, Erik, Mahajan, Anubha, Morris, Andrew, Lind, Lars

“…The accumulation of toxic metals in the human body is influenced by exposure and mechanisms involved in metabolism, some of which may be under genetic control…”
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Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease by Ingelsson, Erik, MD, PhD, Yin, Li, PhD, Bäck, Magnus, MD, PhD

“…Background The leukotriene pathway has been associated with an increased cardiovascular risk. However, the effects of the antileukotriene treatment used in…”
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Body composition and atrial fibrillation: a Mendelian randomization study by Tikkanen, Emmi, Gustafsson, Stefan, Knowles, Joshua W, Perez, Marco, Burgess, Stephen, Ingelsson, Erik

“…Increases in fat-free mass and fat mass have been associated with higher risk of atrial fibrillation (AF) in observational studies. It is not known whether…”
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Dog ownership and the risk of cardiovascular disease and death – a nationwide cohort study by Mubanga, Mwenya, Byberg, Liisa, Nowak, Christoph, Egenvall, Agneta, Magnusson, Patrik K., Ingelsson, Erik, Fall, Tove

“…Dogs may be beneficial in reducing cardiovascular risk in their owners by providing social support and motivation for physical activity. We aimed to…”
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FAM13A affects body fat distribution and adipocyte function by Fathzadeh, Mohsen, Li, Jiehan, Rao, Abhiram, Cook, Naomi, Chennamsetty, Indumathi, Seldin, Marcus, Zhou, Xiang, Sangwung, Panjamaporn, Gloudemans, Michael J., Keller, Mark, Attie, Allan, Yang, Jing, Wabitsch, Martin, Carcamo-Orive, Ivan, Tada, Yuko, Lusis, Aldons J., Shin, Myung Kyun, Molony, Cliona M., McLaughlin, Tracey, Reaven, Gerald, Montgomery, Stephen B., Reilly, Dermot, Quertermous, Thomas, Ingelsson, Erik, Knowles, Joshua W.

“…Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in…”
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Vitamin D Deficiency and Risk of Cardiovascular Disease by WANG, Thomas J, PENCINA, Michael J, BOOTH, Sarah L, JACQUES, Paul F, INGELSSON, Erik, LANIER, Katherine, BENJAMIN, Emelia J, D'AGOSTINO, Ralph B, WOLF, Myles, VASAN, Ramachandran S

“…Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests…”
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Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study by DeBoever, Christopher, Tanigawa, Yosuke, Lindholm, Malene E., McInnes, Greg, Lavertu, Adam, Ingelsson, Erik, Chang, Chris, Ashley, Euan A., Bustamante, Carlos D., Daly, Mark J., Rivas, Manuel A.

“…Protein-truncating variants can have profound effects on gene function and are critical for clinical genome interpretation and generating therapeutic…”
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Use of Multiple Biomarkers to Improve the Prediction of Death from Cardiovascular Causes by Zethelius, Björn, Berglund, Lars, Sundström, Johan, Ingelsson, Erik, Basu, Samar, Larsson, Anders, Venge, Per, Ärnlöv, Johan

“…To predict the risk of death from cardiovascular causes in a community-based cohort of elderly men, the authors used a combination of biomarkers (troponin I,…”
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Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease by Ganna, Andrea, Salihovic, Samira, Sundström, Johan, Broeckling, Corey D, Hedman, Asa K, Magnusson, Patrik K E, Pedersen, Nancy L, Larsson, Anders, Siegbahn, Agneta, Zilmer, Mihkel, Prenni, Jessica, Arnlöv, Johan, Lind, Lars, Fall, Tove, Ingelsson, Erik

“…Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding of…”
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A Nationwide Study of Inpatient Admissions, Mortality, and Costs for Patients with Cirrhosis from 2005 to 2015 in the USA by Zou, Biyao, Yeo, Yee Hui, Jeong, Donghak, Park, Haesuk, Sheen, Edward, Lee, Dong Hyun, Henry, Linda, Garcia, Gabriel, Ingelsson, Erik, Cheung, Ramsey, Nguyen, Mindie H.

“…Background and Aims Liver cirrhosis is a substantial health burden in the USA, but population-based data regarding the trend and medical expenditure are…”
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