Search Results - "Ingel, K"

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial by Brusselle, Guy G, Vanderstichele, Christine, Jordens, Paul, Deman, René, Slabbynck, Hans, Ringoet, Veerle, Verleden, Geert, Demedts, Ingel K, Verhamme, Katia, Delporte, Anja, Demeyere, Bénédicte, Claeys, Geert, Boelens, Jerina, Padalko, Elizaveta, Verschakelen, Johny, Van Maele, Georges, Deschepper, Ellen, Joos, Guy F P

“…Patients with severe asthma are at increased risk of exacerbations and lower respiratory tract infections (LRTI). Severe asthma is heterogeneous, encompassing…”
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Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema by Demedts, Ingel K, Demoor, Tine, Bracke, Ken R, Joos, Guy F, Brusselle, Guy G

“…Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation of the airways and progressive destruction of lung parenchyma, a process…”
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Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial by Declercq, Jozefien, Van Damme, Karel F A, De Leeuw, Elisabeth, Maes, Bastiaan, Bosteels, Cedric, Tavernier, Simon J, De Buyser, Stefanie, Colman, Roos, Hites, Maya, Verschelden, Gil, Fivez, Tom, Moerman, Filip, Demedts, Ingel K, Dauby, Nicolas, De Schryver, Nicolas, Govaerts, Elke, Vandecasteele, Stefaan J, Van Laethem, Johan, Anguille, Sebastien, van der Hilst, Jeroen, Misset, Benoit, Slabbynck, Hans, Wittebole, Xavier, Liénart, Fabienne, Legrand, Catherine, Buyse, Marc, Stevens, Dieter, Bauters, Fre, Seys, Leen J M, Aegerter, Helena, Smole, Ursula, Bosteels, Victor, Hoste, Levi, Naesens, Leslie, Haerynck, Filomeen, Vandekerckhove, Linos, Depuydt, Pieter, van Braeckel, Eva, Rottey, Sylvie, Peene, Isabelle, Van Der Straeten, Catherine, Hulstaert, Frank, Lambrecht, Bart N

“…Infections with SARS-CoV-2 continue to cause significant morbidity and mortality. Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic…”
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Azithromycin during Acute Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization (BACE). A Multicenter, Randomized, Double-Blind, Placebo-controlled Trial by Vermeersch, Kristina, Gabrovska, Maria, Aumann, Joseph, Demedts, Ingel K, Corhay, Jean-Louis, Marchand, Eric, Slabbynck, Hans, Haenebalcke, Christel, Haerens, Michiel, Hanon, Shane, Jordens, Paul, Peché, Rudi, Fremault, Antoine, Lauwerier, Tine, Delporte, Anja, Vandenberk, Bert, Willems, Rik, Everaerts, Stephanie, Belmans, Ann, Bogaerts, Kris, Verleden, Geert M, Troosters, Thierry, Ninane, Vincent, Brusselle, Guy G, Janssens, Wim

“…Azithromycin prevents acute exacerbations of chronic obstructive pulmonary disease (AECOPDs); however, its value in the treatment of an AECOPD requiring…”
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Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19: an open-label randomized controlled trial by De Leeuw, Elisabeth, Van Damme, Karel F A, Declercq, Jozefien, Bosteels, Cedric, Maes, Bastiaan, Tavernier, Simon J, Detalle, Laurent, Smart, Trevor, Glatt, Sophie, Debeuf, Nincy, Deckers, Julie, Lameire, Sahine, Vandecasteele, Stefaan J, De Neve, Nikolaas, Demedts, Ingel K, Govaerts, Elke, Knoop, Christiane, Vanhove, Karolien, Moutschen, Michel, Terryn, Wim, Depuydt, Pieter, Van Braeckel, Eva, Haerynck, Filomeen, Hendrickx, Tine C J, Parrein, Vanessa, Lalla, Marianna, Brittain, Claire, Lambrecht, Bart N

“…The efficacy and safety of complement inhibition in COVID-19 patients is unclear. A multicenter randomized controlled, open-label trial. Hospitalized COVID-19…”
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Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema Are Attenuated in CCR6-Deficient Mice by Bracke, Ken R, D'hulst, An I, Maes, Tania, Moerloose, Katrien B, Demedts, Ingel K, Lebecque, Serge, Joos, Guy F, Brusselle, Guy G

“…Chronic obstructive pulmonary disease (COPD) is mainly caused by cigarette smoking, and is characterized by an increase in inflammatory cells in the airways…”
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Accumulation of Dendritic Cells and Increased CCL20 Levels in the Airways of Patients with Chronic Obstructive Pulmonary Disease by Demedts, Ingel K, Bracke, Ken R, Van Pottelberge, Geert, Testelmans, Dries, Verleden, Geert M, Vermassen, Frank E, Joos, Guy F, Brusselle, Guy G

“…Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation. It is unclear if dendritic cells (DC) participate in this…”
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Dendritic Cells in Chronic Obstructive Pulmonary Disease: New Players in an Old Game by Tsoumakidou, Maria, Demedts, Ingel K, Brusselle, Guy G, Jeffery, Peter K

“…Dendritic cells (DCs) are professional antigen-presenting cells responsible for immune homeostasis. In the lung's responses to tissue damage or infection, they…”
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Matrix metalloproteinases in asthma and COPD by Demedts, Ingel K, Brusselle, Guy G, Bracke, Ken R, Vermaelen, Karim Y, Pauwels, Romain A

“…Asthma and chronic obstructive pulmonary disease (COPD) are both highly prevalent, chronic inflammatory lung diseases that lead to significant morbidity and…”
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Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD by Van Pottelberge, Geert R, Bracke, Ken R, Demedts, Ingel K, De Rijck, Kim, Reinartz, Susanne M, van Drunen, Cornelis M, Verleden, Geert M, Vermassen, Frank E, Joos, Guy F, Brusselle, Guy G

“…Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in…”
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Different Roles for Human Lung Dendritic Cell Subsets in Pulmonary Immune Defense Mechanisms by Demedts, Ingel K, Bracke, Ken R, Maes, Tania, Joos, Guy F, Brusselle, Guy G

“…Dendritic cells (DC) have a central role in the initiation of adequate immune responses. They recognize pathogens by means of Toll-like receptors (TLR) and…”
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Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment by Bosteels, Cedric, Van Damme, Karel F.A., De Leeuw, Elisabeth, Declercq, Jozefien, Maes, Bastiaan, Bosteels, Victor, Hoste, Levi, Naesens, Leslie, Debeuf, Nincy, Deckers, Julie, Cole, Basiel, Pardons, Marion, Weiskopf, Daniela, Sette, Alessandro, Weygaerde, Yannick Vande, Malfait, Thomas, Vandecasteele, Stefaan J., Demedts, Ingel K., Slabbynck, Hans, Allard, Sabine, Depuydt, Pieter, Van Braeckel, Eva, De Clercq, Jozefien, Martens, Liesbet, Dupont, Sam, Seurinck, Ruth, Vandamme, Niels, Haerynck, Filomeen, Roychowdhury, Debasish F., Vandekerckhove, Linos, Guilliams, Martin, Tavernier, Simon J., Lambrecht, Bart N.

“…GM-CSF promotes myelopoiesis and inflammation, and GM-CSF blockade is being evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF…”
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Treatment failure and hospital readmissions in severe COPD exacerbations treated with azithromycin versus placebo - a post-hoc analysis of the BACE randomized controlled trial by Vermeersch, Kristina, Belmans, Ann, Bogaerts, Kris, Gyselinck, Iwein, Cardinaels, Nina, Gabrovska, Maria, Aumann, Joseph, Demedts, Ingel K, Corhay, Jean-Louis, Marchand, Eric, Slabbynck, Hans, Haenebalcke, Christel, Vermeersch, Stefanie, Verleden, Geert M, Troosters, Thierry, Ninane, Vincent, Brusselle, Guy G, Janssens, Wim

“…In the BACE trial, a 3-month (3 m) intervention with azithromycin, initiated at the onset of an infectious COPD exacerbation requiring hospitalization,…”
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Identification and Characterization of Human Pulmonary Dendritic Cells by Demedts, Ingel K, Brusselle, Guy G, Vermaelen, Karim Y, Pauwels, Romain A

“…Dendritic cells (DC) are specialized antigen-presenting cells, linking innate and adaptive immune responses, and thus play an important role in immunologically…”
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Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required? by D'hulst, An I, Maes, Tania, Bracke, Ken R, Demedts, Ingel K, Tournoy, Kurt G, Joos, Guy F, Brusselle, Guy G

“…Chronic obstructive pulmonary disease is associated with a chronic inflammatory response of the host to chronic exposure to inhaled toxic gases and particles…”
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Which outcomes are most important to measure in patients with COVID-19 and how and when should these be measured? Development of an international standard set of outcomes measures for clinical use in patients with COVID-19: a report of the International Consortium for Health Outcomes Measurement (ICHOM) COVID-19 Working Group by Seligman, William H, Fialho, Luz, Sillett, Nick, Nielsen, Christina, Baloch, Farhala M, Collis, Philip, Demedts, Ingel K M, Fleck, Marcelo P, Floriani, Maiara A, Gabriel, Lucinda E K, Gagnier, Joel J, Keetharuth, Anju, Londral, Ana, Ludwig, Ingvar I L, Lumbreras, Carlos, Moscoso Daza, Alejandro, Muhammad, Nasreen, Nader Bastos, Gisele A, Owen, Christine W, Powers, John H, Russell, Anne-Marie, Smith, Michaela K, Wang, Tracy Y-P, Wong, Evan K, Woodhouse, Douglas C, Zimlichman, Eyal, Brinkman, Kees

“…ObjectivesThe COVID-19 pandemic has resulted in widespread morbidity and mortality with the consequences expected to be felt for many years. Significant…”
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The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebo-controlled trial by Vermeersch, Kristina, Gabrovska, Maria, Deslypere, Griet, Demedts, Ingel K, Slabbynck, Hans, Aumann, Joseph, Ninane, Vincent, Verleden, Geert M, Troosters, Thierry, Bogaerts, Kris, Brusselle, Guy G, Janssens, Wim

“…Long-term use of macrolide antibiotics is effective to prevent exacerbations in chronic obstructive pulmonary disease (COPD). As risks and side effects of…”
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Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation by Maes, Tania, Bracke, Ken R, Vermaelen, Karim Y, Demedts, Ingel K, Joos, Guy F, Pauwels, Romain A, Brusselle, Guy G

“…Chronic obstructive pulmonary disease (COPD) is associated with an abnormal inflammatory response of the lungs to noxious particles or gases. We investigated…”
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CC-chemokine receptors in chronic obstructive pulmonary disease by Bracke, Ken R, Demedts, Ingel K, Joos, Guy F, Brusselle, Guy G

“…Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality and disability in the world, with a prevalence that is expected to…”
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Geostrophic flow disturbances influenced by inhomogeneities of gravity field: 3D analytical model by Ingel, Lev K., Makosko, Alexander A.

“…A theoretical problem on linear stationary disturbances introduced by spatial inhomogeneities of gravity field into the background geostrophic flow of the…”
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