Liposomes as carriers of the antiretroviral agent dideoxycytidine-5′-triphosphate

The presence and replication of the human immunodeficiency virus (HIV) in cells of the mononuclear phagocyte system (MPS) together with the preferential uptake of liposomes in macrophages suggest that liposomes can become a valuable carrier of anti-HIV agents. Moreover, liposomes reduce toxicity of...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 180; no. 2; pp. 261 - 270
Main Authors:	Oussoren, C, Magnani, M, Fraternale, A, Casabianca, A, Chiarantini, L, Ingebrigsten, R, Underberg, W.J.M, Storm, G
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 15-04-1999 Elsevier
Subjects:	Animals Anti-HIV Agents - administration & dosage Anti-HIV Agents - chemistry Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents B-Lymphocytes - immunology Biological and medical sciences Chromatography, High Pressure Liquid ddCTP Deoxycytosine Nucleotides - administration & dosage Deoxycytosine Nucleotides - chemistry Deoxycytosine Nucleotides - therapeutic use Dideoxynucleotides DNA, Viral - analysis Drug Carriers Drug Stability Female General pharmacology HIV Liposomes Liposomes - chemistry Lymphocyte Activation - drug effects MAIDS Medical sciences Mice Mice, Inbred C57BL Murine Acquired Immunodeficiency Syndrome - blood Murine Acquired Immunodeficiency Syndrome - drug therapy Murine Acquired Immunodeficiency Syndrome - immunology Particle Size Phagocytes - drug effects Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Proviruses - genetics Solutions Water - chemistry ddCTP Liposomes HIV MAIDS Encapsulation Toxicity Antiviral Immunopathology Stability Pharmaceutical technology Reticuloendothelial system Rodentia Retroviridae Liposome AIDS Immune deficiency Lentivirus Biological activity Infection Virus Vertebrata Mammalia Deoxycytidine Mouse Viral disease Animal Dosage form Human immunodeficiency virus Macrophage
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The presence and replication of the human immunodeficiency virus (HIV) in cells of the mononuclear phagocyte system (MPS) together with the preferential uptake of liposomes in macrophages suggest that liposomes can become a valuable carrier of anti-HIV agents. Moreover, liposomes reduce toxicity of encapsulated drugs and protect encapsulated drugs against rapid degradation in the blood circulation. To overcome problems associated with the administration of free nucleosides and to improve targeting to the MPS, dideoxycytidine-5′-triphosphate (ddCTP) was encapsulated in liposomes. Liposomes were stable with regard to retention of the entrapped drug, particle size and chemical stability of ddCTP. Results obtained with liposome encapsulated ddCTP in the murine acquired immunodeficiency syndrome (MAIDS) model indicate that ddCTP encapsulated in liposomes can reduce proviral DNA in cells of the mononuclear phagocyte system (MPS) in both spleen and bone marrow.
ISSN:	0378-5173 1873-3476
DOI:	10.1016/S0378-5173(99)00016-2