Search Results - "Ingebretsen, William R"

(Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase by Lampe, John W, Chou, Yuo Ling, Hanna, Reda G, Di Meo, Susan V, Erhardt, Paul W, Hagedorn, Alfred A, Ingebretsen, William R, Cantor, Elinor

“…Seven 3-alkyl-4-aryl-1,5-dihydro-2H-pyrrol-2-ones were prepared as potential inhibitors of cardiac cAMP phosphodiesterase (PDE). The design of these compounds…”
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Cardiotonic agents. 7. Prodrug derivatives of 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one by Shaw, Kenneth J, Erhardt, Paul W, Hagedom, Alfred A, Pease, Cynthia A, Ingebretsen, William R, Wiggins, Jay R

“…The cardiotonic agent 4-ethyl-1,3-dihydro-5-4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H- imidazol-2-one (1) was found to have low bioavailability when…”
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Cardiotonic agents. 5. Fragments from the heterocycle-phenyl-imidazole pharmacophore by Erhardt, Paul W, Hagedorn, Alfred A, Davey, David, Pease, Cynthia A, Venepalli, Bhaskar R, Griffin, Carl W, Gomez, Robert P, Wiggins, Jay R, Ingebretsen, William R

“…To examine the role of each component in the heterocycle-phenyl-imidazole inotropic pharmacophore, several imidazolone derivatives, an arylimidazole, a…”
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Cardiotonic agents. 6. Histamine analogs as potential cardiovascular selective H2 agonists by Lampe, John W, Hanna, Reda G, Piscitelli, Thomas A, Chou, Yuo Ling, Erhardt, Paul W, Lumma, William C, Greenberg, Stanley S, Ingebretsen, William R, Marshall, Dennis C, Wiggins, Jay

“…Twenty-six alkyl and aralkyl histamine analogues were prepared as potential cardiotonic agents. Compounds were designed to allow interaction with a putative…”
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Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents by Hagedorn, Alfred A, Erhardt, Paul W, Lumma, William C, Wohl, Ronald A, Cantor, Elinor, Chou, Yuo Ling, Ingebretsen, William R, Lampe, John W, Pang, David

“…A series of 4-alkyl-1,3-dihydro-5-[(1H-imidazolyl)benzoyl]-2H-imidazol-2-ones 9 was synthesized and evaluated in vitro for positive inotropic and cyclic AMP…”
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Nonenzymatic glucosylation of serum proteins and hemoglobin: response to changes in blood glucose levels in diabetic rats by Day, J F, Ingebretsen, C G, Ingebretsen, Jr, W R, Baynes, J W, Thorpe, S R

“…The relationship between concentrations of blood glucose and nonenzymatically glucosylated serum proteins was studied in rats with alloxan-induced diabetes of…”
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Alloxan-induced diabetes reduces beta-adrenergic receptor number without affecting adenylate cyclase in rat ventricular membranes by Ingebretsen, C G, Hawelu-Johnson, C, Ingebretsen, Jr, W R

“…We have investigated alterations in beta-adrenergic receptors and adenylate cyclase activity in myocardial membranes from normal and alloxan-treated diabetic…”
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Electrophysiological Responses of Cardiac Muscle to Isoproterenol Covalently Linked to Glass Beads by BECKER, EBERHARD, INGEBRETSEN, WILLIAM R, MAYERWith, STEVEN E

“…SUMMARY We investigated the effects of isoproterenol aryl glass beads on the electrical properties of cardiac muscle and related these to our previous results…”
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Contractile and Biochemical Responses of Cardiac and Skeletal Muscle to Isoproterenol Covalently Linked to Glass Beads by INGEBRETSEN, WILLIAM R, BECKER, EBERHARD, FRIEDMAN, WILLIAM F, MAYER, STEVEN E

“…The effects of (-)-isoproterenol covalently linked to glass beads on inotropic state, cyclic AMP concentration, and phosphorylase b to a conversion was studied…”
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Studies on gluconeogenesis and stimulation of glycogen and protein synthesis in isolated hepatocytes in alloxan diabetic, normal fed and fasted animals by Wagle, S R, Ingebretsen, W R, Sampson, L

“…Hepatocytes were isolated by collagenase in vitro perfusion technique. Net glucose production in isolated hepatocytes obtained from fed, fasted and alloxan…”
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