Search Results - "Ingall, Anthony H."

From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis by SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G

“…Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described…”
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Optimization of Monocarboxylate Transporter 1 Blockers through Analysis and Modulation of Atropisomer Interconversion Properties by Guile, Simon D., Bantick, John R., Cooper, Martin E., Donald, David K., Eyssade, Christine, Ingall, Anthony H., Lewis, Richard J., Martin, Barrie P., Mohammed, Rukhsana T., Potter, Timothy J., Reynolds, Rachel H., St-Gallay, Stephen A., Wright, Andrew D.

“…We have previously described a novel series of potent blockers of the monocarboxylate transporter, MCT1, which show potent immunomodulatory activity in an…”
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Design-driven LO: The discovery of new ultra long acting dibasic β2-adrenoceptor agonists by CONNOLLY, Stephen, ALCARAZ, Lilian, KANE, Zoe, PAINE, Stuart, PAIRAUDEAU, Garry, STOCKS, Michael J, YOUNG, Alan, BAILEY, Andrew, CADOGAN, Elaine, CHRISTIE, Jadeen, COOK, Anthony R, FISHER, Adrian J, HILL, Stephen, HUMPHRIES, Alexander, INGALL, Anthony H

“…Starting with the molecular scaffold of the DA(2)/β(2) dual agonist sibenadet (Viozan™), a number of molecular changes were incorporated, which were designed…”
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Novel cobalt complex inhibitors of mitochondrial calcium uptake by UNITT, J. F, BODEN, K. L, WALLACE, A. V, INGALL, A. H, COOMBS, M. E, INCE, F

“…Reperfusion of the ischaemic myocardium leads to intracellular calcium overload followed by mitochondrial dysfunction, resulting in insufficient energy supply…”
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Antagonists of the Platelet P 2T Receptor:  A Novel Approach to Antithrombotic Therapy by Ingall, Anthony H, Dixon, John, Bailey, Andrew, Coombs, Mandy E, Cox, David, McInally, Judith I, Hunt, Simon F, Kindon, Nicholas D, Teobald, Barry J, Willis, Paul A, Humphries, Robert G, Leff, Paul, Clegg, Jane A, Smith, James A, Tomlinson, Wendy

“…The platelet P 2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as…”
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Antagonists of the Platelet P2T Receptor:  A Novel Approach to Antithrombotic Therapy by INGALL, Anthony H., DIXON, John, BAILEY, Andrew, COOMBS, Mandy E., COX, David, MCINALLY, Judith I., HUNT, Simon F., KINDON, Nicholas D., TEOBALD, Barry J., WILLIS, Paul A., HUMPHRIES, Robert G., LEFF, Paul, CLEGG, Jane A., SMITH, James A., TOMLINSON, Wendy

“…The platelet P2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as…”
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New antiallergic pyrano[3,2-g]quinoline-2,8-dicarboxylic acids with potential for the topical treatment of asthma by Cairns, Hugh, Cox, David, Gould, Ken J, Ingall, Anthony H, Suschitzky, John L

“…A number of antiallergic pyranquinolinedicarboxylic acid derivatives with potential for the topical treatment of asthma have been synthesized. All the…”
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Design-driven LO: The discovery of new ultra long acting dibasic β 2-adrenoceptor agonists by Connolly, Stephen, Alcaraz, Lilian, Bailey, Andrew, Cadogan, Elaine, Christie, Jadeen, Cook, Anthony R., Fisher, Adrian J., Hill, Stephen, Humphries, Alexander, Ingall, Anthony H., Kane, Zoe, Paine, Stuart, Pairaudeau, Garry, Stocks, Michael J., Young, Alan

“…Starting with the molecular scaffold of the DA 2/β 2 dual agonist sibenadet (Viozan™), a number of molecular changes were incorporated, which were designed to…”
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Design-driven LO: The discovery of new ultra long acting dibasic beta sub(2-adrenoceptor agonists) by Connolly, Stephen, Alcaraz, Lilian, Bailey, Andrew, Cadogan, Elaine, Christie, Jadeen, Cook, Anthony R, Fisher, Adrian J, Hill, Stephen, Humphries, Alexander, Ingall, Anthony H, Kane, Zoe, Paine, Stuart, Pairaudeau, Garry, Stocks, Michael J, Young, Alan

“…Starting with the molecular scaffold of the DA sub(2/ beta ) sub(2) dual agonist sibenadet (Viozan[TM]), a number of molecular changes were incorporated, which…”
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From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis by Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.

“…Starting with ATP, the identification of novel P2Y 12 receptor antagonists are described. The leading compound, 17 (AZD6140), is currently in a phase III…”
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The medicinal chemistry of the P2 receptor family by Guile, S D, Ince, F, Ingall, A H, Kindon, N D, Meghani, P, Mortimore, M P

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