Search Results - "Indrieri, Alessia"

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer by Indrieri, Alessia, Carrella, Sabrina, Carotenuto, Pietro, Banfi, Sandro, Franco, Brunella

“…MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate…”
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Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes by Indrieri, Alessia, Pizzarelli, Rocco, Franco, Brunella, De Leonibus, Elvira

“…Parkinson’s disease (PD) is characterized by motor dysfunctions including bradykinesia, tremor at rest and motor instability. These symptoms are associated…”
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Mutation-Independent Therapies for Retinal Diseases: Focus on Gene-Based Approaches by Carrella, Sabrina, Indrieri, Alessia, Franco, Brunella, Banfi, Sandro

“…Gene therapy is proving to be an effective approach to treat or prevent ocular diseases ensuring a targeted, stable, and regulated introduction of exogenous…”
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Synthetic long non-coding RNAs [SINEUPs] rescue defective gene expression in vivo by Indrieri, Alessia, Grimaldi, Claudia, Zucchelli, Silvia, Tammaro, Roberta, Gustincich, Stefano, Franco, Brunella

“…Non-coding RNAs provide additional regulatory layers to gene expression as well as the potential to being exploited as therapeutic tools. Non-coding RNA-based…”
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α-synuclein overexpression in the retina leads to vision impairment and degeneration of dopaminergic amacrine cells by Marrocco, Elena, Indrieri, Alessia, Esposito, Federica, Tarallo, Valeria, Carboncino, Anna, Alvino, Filomena Grazia, De Falco, Sandro, Franco, Brunella, De Risi, Maria, De Leonibus, Elvira

“…The presence of α-synuclein aggregates in the retina of Parkinson’s disease patients has been associated with vision impairment. In this study we sought to…”
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miR‐181a/b downregulation exerts a protective action on mitochondrial disease models by Indrieri, Alessia, Carrella, Sabrina, Romano, Alessia, Spaziano, Alessandra, Marrocco, Elena, Fernandez‐Vizarra, Erika, Barbato, Sara, Pizzo, Mariateresa, Ezhova, Yulia, Golia, Francesca M, Ciampi, Ludovica, Tammaro, Roberta, Henao‐Mejia, Jorge, Williams, Adam, Flavell, Richard A, De Leonibus, Elvira, Zeviani, Massimo, Surace, Enrico M, Banfi, Sandro, Franco, Brunella

“…Mitochondrial diseases (MDs) are a heterogeneous group of devastating and often fatal disorders due to defective oxidative phosphorylation. Despite the recent…”
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Microglia reactivity entails microtubule remodeling from acentrosomal to centrosomal arrays by Rosito, Maria, Sanchini, Caterina, Gosti, Giorgio, Moreno, Manuela, De Panfilis, Simone, Giubettini, Maria, Debellis, Doriana, Catalano, Federico, Peruzzi, Giovanna, Marotta, Roberto, Indrieri, Alessia, De Leonibus, Elvira, De Stefano, Maria Egle, Ragozzino, Davide, Ruocco, Giancarlo, Di Angelantonio, Silvia, Bartolini, Francesca

“…Microglia reactivity entails a large-scale remodeling of cellular geometry, but the behavior of the microtubule cytoskeleton during these changes remains…”
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The Role of MicroRNAs in Mitochondria-Mediated Eye Diseases by Carrella, Sabrina, Massa, Filomena, Indrieri, Alessia

“…The retina is among the most metabolically active tissues with high-energy demands. The peculiar distribution of mitochondria in cells of retinal layers is…”
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Integrated Genomics Identifies miR-181/TFAM Pathway as a Critical Driver of Drug Resistance in Melanoma by Barbato, Anna, Iuliano, Antonella, Volpe, Mariagrazia, D'Alterio, Romina, Brillante, Simona, Massa, Filomena, De Cegli, Rossella, Carrella, Sabrina, Salati, Massimiliano, Russo, Annapina, Russo, Giulia, Riccardo, Sara, Cacchiarelli, Davide, Capone, Mariaelena, Madonna, Gabriele, Ascierto, Paolo A, Franco, Brunella, Indrieri, Alessia, Carotenuto, Pietro

“…MicroRNAs (miRNAs) are attractive therapeutic targets and promising candidates as molecular biomarkers for various therapy-resistant tumors. However, the…”
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miR‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases by Carrella, Sabrina, Di Guida, Martina, Brillante, Simona, Piccolo, Davide, Ciampi, Ludovica, Guadagnino, Irene, Garcia Piqueras, Jorge, Pizzo, Mariateresa, Marrocco, Elena, Molinari, Marta, Petrogiannakis, Georgios, Barbato, Sara, Ezhova, Yulia, Auricchio, Alberto, Franco, Brunella, De Leonibus, Elvira, Surace, Enrico Maria, Indrieri, Alessia, Banfi, Sandro

“…Inherited retinal diseases (IRDs) are a group of diseases whose common landmark is progressive photoreceptor loss. The development of gene‐specific therapies…”
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Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease by Tarallo, Antonietta, Damiano, Carla, Strollo, Sandra, Minopoli, Nadia, Indrieri, Alessia, Polishchuk, Elena, Zappa, Francesca, Nusco, Edoardo, Fecarotta, Simona, Porto, Caterina, Coletta, Marcella, Iacono, Roberta, Moracci, Marco, Polishchuk, Roman, Medina, Diego Luis, Imbimbo, Paola, Monti, Daria Maria, De Matteis, Maria Antonietta, Parenti, Giancarlo

“…Pompe disease is a metabolic myopathy due to acid alpha‐glucosidase deficiency. In addition to glycogen storage, secondary dysregulation of cellular functions,…”
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COVID-19: High-JAKing of the Inflammatory "Flight" by Ruxolitinib to Avoid the Cytokine Storm by Botta, Cirino, Indrieri, Alessia, Garofalo, Eugenio, Biamonte, Flavia, Bruni, Andrea, Pasqua, Pino, Cesario, Francesco, Costanzo, Francesco Saverio, Longhini, Federico, Mendicino, Francesco

“…Since SARS-CoV-2 outbreak in December 2019, world health-system has been severely impacted with increased hospitalization, Intensive-Care-Unit (ICU) access and…”
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MicroRNAs Modulation: a novel frontier in the treatment of mitochondrial optic neuropathies by Indrieri, Alessia

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The impairment of HCCS leads to MLS syndrome by activating a non‐canonical cell death pathway in the brain and eyes by Indrieri, Alessia, Conte, Ivan, Chesi, Giancarlo, Romano, Alessia, Quartararo, Jade, Tatè, Rosarita, Ghezzi, Daniele, Zeviani, Massimo, Goffrini, Paola, Ferrero, Ileana, Bovolenta, Paola, Franco, Brunella

“…Mitochondrial‐dependent (intrinsic) programmed cell death (PCD) is an essential homoeostatic mechanism that selects bioenergetically proficient cells suitable…”
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Erratum To: The impairment of HCCS leads to MLS syndrome by activating a non‐canonical cell death pathway in the brain and eyes by Indrieri, Alessia, Conte, Ivan, Chesi, Giancarlo, Romano, Alessia, Quartararo, Jade, Tatè, Rosarita, Ghezzi, Daniele, Zeviani, Massimo, Goffrini, Paola, Ferrero, Ileana, Bovolenta, Paola, Franco, Brunella

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Advances in MicroRNA Therapeutics: From Preclinical to Clinical Studies by Brillante, Simona, Volpe, Mariagrazia, Indrieri, Alessia

“…MicroRNAs (miRNAs) are crucial regulators of gene expression involved in various pathophysiological processes. Their ability to modulate multiple pathways…”
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Linear Skin Defects with Multiple Congenital Anomalies (LSDMCA): An Unconventional Mitochondrial Disorder by Indrieri, Alessia, Franco, Brunella

“…Mitochondrial disorders, although heterogeneous, are traditionally described as conditions characterized by encephalomyopathy, hypotonia, and progressive…”
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MicroRNA-181a/b modulation as possible therapeutic strategy for Autosomal Dominant Optic Atrophy by Saurino, Rosa, Molinari, Marta, Massa, Filomena, Marrocco, Elena, Volpe, Mariagrazia, Crina, Claudia, Votruba, Marcela, Indrieri, Alessia

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Preserving mitochondria by miR-181a/b modulation as therapeutic strategy for Stargardt disease by Brillante, Simona, Anna, Diana, Volpe, Mariagrazia, Cipollaro, Eva, Molinari, Marta, Banfi, Sandro, Carrella, Sabrina, Indrieri, Alessia

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Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis by Polishchuk, Elena V., Merolla, Assunta, Lichtmannegger, Josef, Romano, Alessia, Indrieri, Alessia, Ilyechova, Ekaterina Y., Concilli, Mafalda, De Cegli, Rossella, Crispino, Roberta, Mariniello, Marta, Petruzzelli, Raffaella, Ranucci, Giusy, Iorio, Raffaele, Pietrocola, Federico, Einer, Claudia, Borchard, Sabine, Zibert, Andree, Schmidt, Hartmut H., Di Schiavi, Elia, Puchkova, Ludmila V., Franco, Brunella, Kroemer, Guido, Zischka, Hans, Polishchuk, Roman S.

“…Wilson disease (WD) is an inherited disorder of copper metabolism that leads to copper accumulation and toxicity in the liver and brain. It is caused by…”
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