Paternal age and common mental disorders

Introduction. There is evidence in the literature that there are associations between advancing paternal age and psychosis or more specifically schizophrenia, but not enough to support a strong link between advancing paternal age and common mental disorders. Objective. This study aims to explain the...

Full description

Saved in:

Bibliographic Details
Published in:	The world journal of biological psychiatry Vol. 10; no. 4_2; pp. 518 - 523
Main Authors:	Krishnaswamy, Saroja, Subramaniam, Kavitha, Indran, Haymanth, Ramachandran, Padma, Indran, Tishya, Indran, Ramesh, Aziz, Jemain Abdul
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 2009 Taylor & Francis
Subjects:	Adolescent Adult Anxiety Disorders - epidemiology Anxiety Disorders - etiology common mental disorders Cross-Sectional Studies Depressive Disorder - epidemiology Depressive Disorder - etiology Female Health Surveys Humans Infant, Newborn Malaysia Male Maternal Age Mental Disorders - epidemiology Mental Disorders - etiology Middle Aged Paternal Age Phobic Disorders - epidemiology Phobic Disorders - etiology Pregnancy Risk Factors Young Adult Malaysia
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Introduction. There is evidence in the literature that there are associations between advancing paternal age and psychosis or more specifically schizophrenia, but not enough to support a strong link between advancing paternal age and common mental disorders. Objective. This study aims to explain the association between paternal age at birth and common mental disorders in progeny during their adulthood. Methodology. This is a sub-study from a larger survey which was planned to study the epidemiology of mental disorders in Malaysia. Respondents who could remember the age of parents at birth were included in the study. The diagnosis of common mental disorders (CMD) was made using the CIS-R (Clinical Interview Schedule-Revised) instrument in the PROQSY (Programmed Questionnaire System) format. Association between paternal age at birth and CMD was studied using logistic regression, after controlling for age, gender, ethnicity and presence of family history of mental disorders. Results. Respondents with paternal age at birth of 19 and below and 50 above and had higher rates of 10 and 25% for common mental disorders ( 2=7.007, P=0.072) with odds ratios of 2.89 (95% CI of OR = 1.1-7.6) and 4.28 (1.4-12.7). Discussion. Progenies of fathers under 20 and over 50 had higher risk for mental disorders. Factors such as immaturity in sperm of teenage fathers, mutation in germ line of older fathers, environmental and psychosocial factors could have contributed to increased prevalence of common mental disorders in the progeny.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1562-2975 1814-1412
DOI:	10.1080/15622970802653691