Search Results - "Indra, Arup K"

Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans by Li, Shan, Ganguli-Indra, Gitali, Indra, Arup K

“…Lipidomics is the large-scale profiling and characterization of lipid species in a biological system using mass spectrometry. The skin barrier is mainly…”
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The Role of the Vitamin D Receptor in the Pathogenesis, Prognosis, and Treatment of Cutaneous Melanoma by Becker, Alyssa L, Carpenter, Evan L, Slominski, Andrzej T, Indra, Arup K

“…Melanoma is the malignant transformation of melanocytes and represents the most lethal form of skin cancer. While early-stage melanoma localized to the skin…”
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Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells by Pinkham, Kelsey, Park, David Jaehyun, Hashemiaghdam, Arsalan, Kirov, Aleksandar B., Adam, Isam, Rosiak, Kamila, da Hora, Cintia C., Teng, Jian, Cheah, Pike See, Carvalho, Litia, Ganguli-Indra, Gitali, Kelly, Avalon, Indra, Arup K., Badr, Christian E.

“…Inherent plasticity and various survival cues allow glioblastoma stem-like cells (GSCs) to survive and proliferate under intrinsic and extrinsic stress…”
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Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo by Bhattacharya, Nilika, Indra, Arup K., Ganguli-Indra, Gitali

“…Transcriptional regulator BCL11A plays a crucial role in coordinating a suite of developmental processes including skin morphogenesis, barrier functions and…”
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Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis by Hyter, Stephen, Indra, Arup K.

“…Skin homeostasis is maintained, in part, through regulation of gene expression orchestrated by type II nuclear hormone receptors in a cell and context specific…”
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Asymmetric Synthesis and Biological Activities of Pactamycin-Inspired Aminocyclopentitols by Brumsted, Corey J, Carpenter, Evan L, Indra, Arup K, Mahmud, Taifo

“…Pactamycin is a structurally unique aminocyclitol antibiotic with broad-spectrum cell growth inhibitory activity. To explore the bountiful activity of the…”
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Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts by Serrill, Jeffrey D., Wan, Xuemei, Hau, Andrew M., Jang, Hyo Sang, Coleman, Daniel J., Indra, Arup K., Alani, Adam W. G., McPhail, Kerry L., Ishmael, Jane E.

“…Summary Coibamide A is a cytotoxic lariat depsipeptide isolated from a rare cyanobacterium found within the marine reserve of Coiba National Park, Panama…”
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Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling by Zhang, Ling-juan, Bhattacharya, Shreya, Leid, Mark, Ganguli-Indra, Gitali, Indra, Arup K

“…Epidermal morphogenesis results from a delicate balance between keratinocyte proliferation and differentiation, and this balance is perturbed upon deletion of…”
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Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas by Chagani, Sharmeen, Wang, Rong, Carpenter, Evan L, Löhr, Christiane V, Ganguli-Indra, Gitali, Indra, Arup K

“…Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment…”
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Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis by Hyter, Stephen, Coleman, Daniel J., Ganguli-Indra, Gitali, Merrill, Gary F., Ma, Steven, Yanagisawa, Masashi, Indra, Arup K.

“…Summary Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here, we…”
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Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice by Wang, Zhixing, Zhang, Ling-Juan, Guha, Gunjan, Li, Shan, Kyrylkova, Kateryna, Kioussi, Chrissa, Leid, Mark, Ganguli-Indra, Gitali, Indra, Arup K

“…Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to…”
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Photoprotective Properties of Isothiocyanate and Nitrile Glucosinolate Derivatives From Meadowfoam ( Limnanthes alba ) Against UVB Irradiation in Human Skin Equivalent by Carpenter, Evan L, Le, Mai N, Miranda, Cristobal L, Reed, Ralph L, Stevens, Jan F, Indra, Arup K, Ganguli-Indra, Gitali

“…Exposure to ultraviolet B (UVB) irradiation of the skin leads to numerous dermatological concerns including skin cancer and accelerated aging. Natural product…”
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Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation by Coleman, Daniel J, Garcia, Gloria, Hyter, Stephen, Jang, Hyo Sang, Chagani, Sharmeen, Liang, Xiaobo, Larue, Lionel, Ganguli-Indra, Gitali, Indra, Arup K

“…Understanding the molecular mechanisms of ultraviolet (UV) induced melanoma formation is becoming crucial with more reported cases each year. Expression of…”
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Dual Role of COUP-TF-Interacting Protein 2 in Epidermal Homeostasis and Permeability Barrier Formation by Golonzhka, Olga, Liang, Xiaobo, Messaddeq, Nadia, Bornert, Jean-Marc, Campbell, Adam L., Metzger, Daniel, Chambon, Pierre, Ganguli-Indra, Gitali, Leid, Mark, Indra, Arup K.

“…COUP-TF-interacting protein 2 (CTIP2; also known as Bcl11b) is a transcription factor that plays key roles in the development of the central nervous and immune…”
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Epidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis by Bhattacharya, Nilika, Sato, William J., Kelly, Avalon, Ganguli-Indra, Gitali, Indra, Arup K.

“…The skin barrier keeps the ‘inside in’ and the ‘outside out’, forming a protective blanket against external insults. Epidermal lipids, such as ceramides, fatty…”
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Skin Lipid Composition Varies Based on Clinical Subphenotypes in Adult European American Atopic Dermatitis Subjects by Indra, Arup K., Professor, Li, Shan, Villarreal, Miguel, Babineau, Denise C., PhD, Philpot, Catherine, David, Gloria, PhD, Boguniewicz, Mark, Hanifin, Jon M., MD, FAAAAI, Leung, Donald Y.M., MD, PhD, FAAAAI, Simpson, Eric L, Beck, Lisa A., MD, FAAAAI

“…Rationale Atopic dermatitis (AD) is an inflammatory skin condition with well-recognized subphenotypes distinguished by physiological measures of skin barrier…”
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Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis by Indra, Arup K

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CTIP2 expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status by Ganguli-Indra, Gitali, Wasylyk, Christine, Liang, Xiaobo, Millon, Regine, Leid, Mark, Wasylyk, Bohdan, Abecassis, Joseph, Indra, Arup K, Indra, Arup

“…We have demonstrated earlier that CTIP2 is highly expressed in mouse skin during embryogenesis and in adulthood. CTIP2 mutant mice die at birth with epidermal…”
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Oxidative Stress in Melanoma: Beneficial Antioxidant and Pro-Oxidant Therapeutic Strategies by Becker, Alyssa L, Indra, Arup K

“…Cutaneous melanoma ranks as the fifth most common cancer in the United States and represents one of the deadliest forms of skin cancer. While recent advances…”
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NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation by Carpenter, Evan L, Becker, Alyssa L, Indra, Arup K

“…Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar…”
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