Search Results - "Indira Chandran, Vineesh"

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis by Menard, Julien A, Christianson, Helena C, Kucharzewska, Paulina, Bourseau-Guilmain, Erika, Svensson, Katrin J, Lindqvist, Eva, Indira Chandran, Vineesh, Kjellén, Lena, Welinder, Charlotte, Bengzon, Johan, Johansson, Maria C, Belting, Mattias

“…Hypoxia and acidosis are inherent stress factors of the tumor microenvironment and have been linked to increased tumor aggressiveness and treatment resistance…”
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Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics by Indira Chandran, Vineesh, Welinder, Charlotte, Gonçalves de Oliveira, Kelin, Cerezo-Magaña, Myriam, Månsson, Ann-Sofie, Johansson, Maria C., Marko-Varga, Gyorgy, Belting, Mattias

“…Purpose Glioblastoma multiforme (GBM) is the most common and lethal of primary malignant brain tumors. Hypoxia constitutes a major determining factor for the…”
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Extracellular vesicles in glioblastoma: a challenge and an opportunity by Indira Chandran, Vineesh, Gopala, Srinivas, Venkat, Easwer Hariharan, Kjolby, Mads, Nejsum, Peter

“…Glioblastoma is a highly heterogeneous tumor whose pathophysiological complexities dictate both the diagnosis of disease severity as well as response to…”
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Interplay between Caveolin-1 and body and tumor size affects clinical outcomes in breast cancer by Godina, Christopher, Indira Chandran, Vineesh, Barbachowska, Magdalena, Tryggvadottir, Helga, Nodin, Björn, Visse, Edward, Borgquist, Signe, Jirström, Karin, Isaksson, Karolin, Bosch, Ana, Belting, Mattias, Jernström, Helena

“…•Breast tumor CAV1 levels were assessed in relation to phenotype and prognosis.•CAV1’s prognostic impact depended on anthropometric and tumor factors.•Stromal…”
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Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration by Offer, Svenja, Menard, Julien A, Pérez, Julio Enríquez, de Oliveira, Kelin G, Indira Chandran, Vineesh, Johansson, Maria C, Bång-Rudenstam, Anna, Siesjö, Peter, Ebbesson, Anna, Hedenfalk, Ingrid, Sundgren, Pia C, Darabi, Anna, Belting, Mattias

“…Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic…”
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Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity by Christianson, Helena C, Menard, Julien A, Indira Chandran, Vineesh, Bourseau-Guilmain, Erika, Shevela, Dmitry, Lidfeldt, Jon, Månsson, Ann-Sofie, Pastorekova, Silvia, Messinger, Johannes, Belting, Mattias

“…Aggressive cancers are characterized by hypoxia, which is a key driver of tumor development and treatment resistance. Proteins specifically expressed in the…”
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The prevalence and risk factors for cognitive impairment in obesity and NAFLD by Wernberg, Charlotte W, Grønkjær, Lea L, Gade Jacobsen, Birgitte, Chandran, Vineesh I, Krag, Aleksander, Graversen, Jonas H, Weissenborn, Karin, Vilstrup, Hendrik, Lauridsen, Mette M

“…Severe obesity may be accompanied by cognitive dysfunction and NAFLD, but the associations remain unclear. We describe the prevalence and features of cognitive…”
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Stellate cell expression of SPARC-related modular calcium-binding protein 2 is associated with human non-alcoholic fatty liver disease severity by Larsen, Frederik T., Hansen, Daniel, Terkelsen, Mike K., Bendixen, Sofie M., Avolio, Fabio, Wernberg, Charlotte W., Lauridsen, Mette M., Grønkjaer, Lea L., Jacobsen, Birgitte G., Klinggaard, Ellen G., Mandrup, Susanne, Di Caterino, Tina, Siersbæk, Majken S., Chandran, Vineesh Indira, Graversen, Jonas H., Krag, Aleksander, Grøntved, Lars, Ravnskjaer, Kim

“…Histological assessment of liver biopsies is the gold standard for diagnosis of non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic…”
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HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer by Indira Chandran, Vineesh, Eppenberger-Castori, Serenella, Venkatesh, Thejaswini, Vine, Kara Lea, Ranson, Marie

“…Human epidermal growth factor receptor type 2 (HER2)-positive breast carcinoma is highly aggressive and mostly metastatic in nature though curable/manageable…”
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Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma by Indira Chandran, Vineesh, Welinder, Charlotte, Månsson, Ann-Sofie, Offer, Svenja, Freyhult, Eva, Pernemalm, Maria, Lund, Sigrid M, Pedersen, Shona, Lehtiö, Janne, Marko-Varga, Gyorgy, Johansson, Maria C, Englund, Elisabet, Sundgren, Pia C, Belting, Mattias

“…Liquid biopsy has great potential to improve the management of brain tumor patients at high risk of surgery-associated complications. Here, the aim was to…”
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Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness by Indira Chandran, Vineesh, Wernberg, Charlotte Wilhelmina, Lauridsen, Mette Munk, Skytthe, Maria Kløjgaard, Bendixen, Sofie Marchsteiner, Larsen, Frederik Tibert, Hansen, Camilla Dalby, Grønkjær, Lea Ladegaard, Siersbæk, Majken Storm, Caterino, Tina Di, Detlefsen, Sönke, Møller, Holger Jon, Grøntved, Lars, Ravnskjaer, Kim, Moestrup, Søren Kragh, Thiele, Maja Sofie, Krag, Aleksander, Graversen, Jonas Heilskov

“…Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating…”
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Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1 by Indira Chandran, Vineesh, Månsson, Ann-Sofie, Barbachowska, Magdalena, Cerezo-Magaña, Myriam, Nodin, Björn, Joshi, Bharat, Koppada, Neelima, Saad, Ola M, Gluz, Oleg, Isaksson, Karolin, Borgquist, Signe, Jirström, Karin, Nabi, Ivan Robert, Jernström, Helena, Belting, Mattias

“…The antibody-drug conjugate trastuzumab-emtansine (T-DM1) offers an additional treatment option for patients with HER2-amplified tumors. However, primary and…”
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Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery by Vine, Kara Lea, Lobov, Sergei, Chandran, Vineesh Indira, Harris, Nathanial Lachlan Ewart, Ranson, Marie

“…Purpose Overexpression of the serine protease urokinase (uPA) is recognised as an important biomarker of metastatic disease and a druggable anticancer target…”
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Anti-cancer activity of an acid-labile N -alkylisatin conjugate targeting the transferrin receptor by Indira Chandran, Vineesh, Matesic, Lidia, Locke, Julie M, Skropeta, Danielle, Ranson, Marie, Vine, Kara L

“…Abstract We have previously reported a series of pH-sensitive imine-linked N -alkylisatin prodrugs that are stable at pH 7.4, but readily cleaved at pH 4.5…”
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Obese Patients With Nonalcoholic Fatty Liver Disease Have an Increase in Soluble Plasma CD163 and a Concurrent Decrease in Hepatic Expression of CD163 by Skytthe, Maria Kløjgaard, Pedersen, Felix Boel, Wernberg, Charlotte Wilhelmina, Indira Chandran, Vineesh, Krag, Aleksander, Di Caterino, Tina, Mandacaru, Samuel Coelho, Blagoev, Blagoy, Lauridsen, Mette Munk, Detlefsen, Sönke, Graversen, Jonas Heilskov, Moestrup, Søren Kragh

“…Macrophages play an important role in the development of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH)…”
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Micro RNA profiles of host extracellular vesicles are modulated by Ascaris suum infection but parasite extracellular vesicle miRNAs are systemically undetectable using in-depth miRNA sequencing by Whitehead, Bradley, Sørensen Rossen, Litten, Zippor, Mads, Boysen, Anders T., Indira Chandran, Vineesh, Skallerup, Per, Thamsborg, Stig M., Nejsum, Peter

“…[Display omitted] •Ascaris suum extracellular vesicles (EVs) are recognised by the host adaptive immune response.•Ascaris suum EVs generate antibody…”
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THU-455 - Cognitive impairment is frequent in obesity and not restricted to persons with biopsy-proven NAFLD by Wernberg, Charlotte, Grønkjær, Lea Ladegaard, Jacobsen, Birgitte, Chandran, Vineesh Indira, Graversen, Jonas, Krag, Aleksander, Weissenborn, Karin, Vilstrup, Hendrik, Lauridsen, Mette Munk

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Cognitive impairment is frequent in obesity and not restricted to persons with biopsy-proven NAFLD by Wernberg, Charlotte, Grønkjær, Lea Ladegaard, Jacobsen, Birgitte, Chandran, Vineesh Indira, Graversen, Jonas, Krag, Aleksander, Weissenborn, Karin, Vilstrup, Hendrik, Lauridsen, Mette Munk

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SAT-404 - Soluble TREM2 and PRO-C3 as efficacy of intervention markers in NASH by Wernberg, Charlotte, Chandran, Vineesh Indira, Lauridsen, Mette, Skytthe, Maria Kløjgaard, Hansen, Camilla Dalby, Hansen, Johanne Kragh, Grønkjær, Lea Ladegaard, Jacobsen, Birgitte, Di Caterino, Tina, Detlefsen, Sönke, Thiele, Maja, Guiliani, Alejandro Mayorca, Leeming, Diana, Karsdal, Morten, Villesen, Ida, Graversen, Jonas, Krag, Aleksander

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Soluble TREM2 and PRO-C3 as efficacy of intervention markers in NASH by Wernberg, Charlotte, Chandran, Vineesh Indira, Lauridsen, Mette, Skytthe, Maria Kløjgaard, Hansen, Camilla Dalby, Hansen, Johanne Kragh, Grønkjær, Lea Ladegaard, Jacobsen, Birgitte, Di Caterino, Tina, Detlefsen, Sönke, Thiele, Maja, Guiliani, Alejandro Mayorca, Leeming, Diana, Karsdal, Morten, Villesen, Ida, Graversen, Jonas, Krag, Aleksander

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