Search Results - "Indeykina, Maria I."
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Urinary Protein and Peptide Markers in Chronic Kidney Disease
Published in International journal of molecular sciences (09-11-2021)“…Chronic kidney disease (CKD) is a non-specific type of kidney disease that causes a gradual decline in kidney function (from months to years). CKD is a…”
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Potential Urine Proteomic Biomarkers for Focal Segmental Glomerulosclerosis and Minimal Change Disease
Published in International journal of molecular sciences (20-10-2022)“…Primary focal segmental glomerulosclerosis (FSGS), along with minimal change disease (MCD), are diseases with primary podocyte damage that are clinically…”
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Quantitative Assessment of Serine-8 Phosphorylated β-Amyloid Using MALDI-TOF Mass Spectrometry
Published in Molecules (Basel, Switzerland) (01-12-2022)“…The study of the molecular mechanisms of the pathogenesis of Alzheimer's disease (AD) is extremely important for identifying potential therapeutic targets as…”
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Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer's Amyloid-β with Taiwan (D7H) Mutation
Published in International journal of molecular sciences (01-07-2023)“…Amyloid-β (Aβ) is a peptide formed by 39-43 amino acids, heterogenous by the length of its C-terminus. Aβ constitutes a subnanomolar monomeric component of…”
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Targeted MRM Quantification of Urinary Proteins in Chronic Kidney Disease Caused by Glomerulopathies
Published in Molecules (Basel, Switzerland) (01-04-2023)“…Glomerulopathies with nephrotic syndrome that are resistant to therapy often progress to end-stage chronic kidney disease (CKD) and require timely and accurate…”
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The Effects of Spaceflight Factors on the Human Plasma Proteome, Including Both Real Space Missions and Ground-Based Experiments
Published in International journal of molecular sciences (29-06-2019)“…The aim of the study was to compare proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based…”
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Prognosis of Alzheimer's Disease Using Quantitative Mass Spectrometry of Human Blood Plasma Proteins and Machine Learning
Published in International journal of molecular sciences (18-07-2022)“…Early recognition of the risk of Alzheimer's disease (AD) onset is a global challenge that requires the development of reliable and affordable screening…”
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The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer's Disease
Published in International journal of molecular sciences (21-12-2021)“…Alzheimer's disease (AD) is the leading cause of dementia among the elderly. Neuropathologically, AD is characterized by the deposition of a 39- to 42-amino…”
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Conservative and Atypical Ferritins of Sponges
Published in International journal of molecular sciences (11-08-2021)“…Ferritins comprise a conservative family of proteins found in all species and play an essential role in resistance to redox stress, immune response, and cell…”
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Absolute Quantitative Targeted Monitoring of Potential Plasma Protein Biomarkers: A Pilot Study on Healthy Individuals
Published in Biomedicines (21-10-2024)“…The development of blood tests for the early detection of individual predisposition to socially significant diseases remains a pressing issue. In this pilot…”
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Differential Diagnosis of Preeclampsia Based on Urine Peptidome Features Revealed by High Resolution Mass Spectrometry
Published in Diagnostics (Basel) (03-12-2020)“…Preeclampsia (PE) is a severe pregnancy complication, which may be considered as a systemic response in the second half of pregnancy to physiological failures…”
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Mass-Spectrometric Detection of SARS-CoV‑2 Virus in Scrapings of the Epithelium of the Nasopharynx of Infected Patients via Nucleocapsid N Protein
Published in Journal of proteome research (06-11-2020)“…The detection of viral RNA by polymerase chain reaction (PCR) is currently the main diagnostic tool for COVID-19 ( Eurosurveillance 2019, 25 (3), 1 ). The…”
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The Strategy for Peptidomic LC-MS/MS Data Analysis: The Case of Urinary Peptidome Study
Published in Methods in molecular biology (Clifton, N.J.) (2024)“…The study of urinary peptidome is an important area of research, which concerns the characterization of endogenous peptides, as well as the identification of…”
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Mass spectrometric studies of the variety of beta-amyloid proteoforms in Alzheimer's disease
Published in Mass spectrometry reviews (28-03-2022)“…This review covers the results of the application of mass spectrometric (MS) techniques to study the diversity of beta-amyloid (Aβ) peptides in human samples…”
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Label‐free cervicovaginal fluid proteome profiling reflects the cervix neoplastic transformation
Published in Journal of mass spectrometry. (01-08-2019)“…Cervicovaginal fluid (CVF) is a valuable source of clinical information about the female reproductive tract in both nonpregnant and pregnant women. The aim of…”
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A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid‐β Fragment with Taiwanese Mutation D7H
Published in Angewandte Chemie International Edition (18-09-2017)“…Zinc‐induced oligomerization of amyloid‐β peptide (Aβ) produces potentially pathogenic agents of Alzheimer's disease. Mutations and modifications in the metal…”
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Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2
Published in Scientific reports (27-12-2019)“…We have investigated covalent conjugation of VPPPVPPRRRX′ peptide (where X′ denotes N ε -chloroacetyl lysine) to N-terminal SH3 domain from adapter protein…”
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Proteomic Markers and Early Prediction of Alzheimer’s Disease
Published in Biochemistry (Moscow) (01-08-2022)“…Alzheimer’s disease (AD) is the most common socially significant neurodegenerative pathology, which currently affects more than 30 million elderly people…”
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Probabilistic model applied to ion abundances in product-ion spectra: quantitative analysis of aspartic acid isomerization in peptides
Published in Analytical and bioanalytical chemistry (01-11-2019)“…Evaluation of post-translational modifications of protein molecules is important for both basic and applied biomedical research. Mass spectrometric…”
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Relative Quantitation of Beta-Amyloid Peptide Isomers with Simultaneous Isomerization of Multiple Aspartic Acid Residues by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry
Published in Journal of the American Society for Mass Spectrometry (02-01-2020)“…Matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry can be used for rapid quantitation of peptides with various…”
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