Search Results - "Ince, Tan A"

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers by Mendillo, Marc L., Santagata, Sandro, Koeva, Martina, Bell, George W., Hu, Rong, Tamimi, Rulla M., Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan

“…Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model…”
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HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells by Caslini, Corrado, Hong, Sunhwa, Ban, Yuguang J., Chen, Xi S., Ince, Tan A.

“…Chromatin regulation through histone modifications plays an essential role in coordinated expression of multiple genes. Alterations in chromatin induced by…”
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Reference-free deconvolution of DNA methylation data and mediation by cell composition effects by Houseman, E Andres, Kile, Molly L, Christiani, David C, Ince, Tan A, Kelsey, Karl T, Marsit, Carmen J

“…Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the…”
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A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells by Petrocca, Fabio, Altschuler, Gabriel, Tan, Shen Mynn, Mendillo, Marc L., Yan, Haoheng, Jerry, D. Joseph, Kung, Andrew L., Hide, Winston, Ince, Tan A., Lieberman, Judy

“…Basal-like triple-negative breast cancers (TNBCs) have poor prognosis. To identify basal-like TNBC dependencies, a genome-wide siRNA lethality screen compared…”
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Of Mice and Women: A Comparative Tissue Biology Perspective of Breast Stem Cells and Differentiation by Dontu, Gabriela, Ince, Tan A.

“…Tissue based research requires a background in human and veterinary pathology, developmental biology, anatomy, as well as molecular and cellular biology. This…”
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A triple hormone receptor ER, AR, and VDR signature is a robust prognosis predictor in breast cancer by Omar, Mohamed, Harrell, J Chuck, Tamimi, Rulla, Marchionni, Luigi, Erdogan, Cihat, Nakshatri, Harikrishna, Ince, Tan A

“…Despite evidence indicating the dominance of cell-of-origin signatures in molecular tumor patterns, translating these genome-wide patterns into actionable…”
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Cell-of-Origin Targeted Drug Repurposing for Triple-Negative and Inflammatory Breast Carcinoma with HDAC and HSP90 Inhibitors Combined with Niclosamide by Bhattacharya, Udayan, Kamran, Mohammad, Manai, Maroua, Cristofanilli, Massimo, Ince, Tan A

“…We recently identified a cell-of-origin-specific mRNA signature associated with metastasis and poor outcome in triple-negative carcinoma (TNBC). This TNBC…”
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Ectopic protein interactions within BRD4–chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma by Alekseyenko, Artyom A., Walsh, Erica M., Zee, Barry M., Pakozdi, Tibor, Hsi, Peter, Lemieux, Madeleine E., Dal Cin, Paola, Ince, Tan A., Kharchenko, Peter V., Kuroda, Mitzi I., French, Christopher A.

“…To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT midline carcinoma (NMC), we have identified protein interactions…”
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High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer by Santagata, Sandro, Hu, Rong, Lin, Nancy U, Mendillo, Marc L, Collins, Laura C, Hankinson, Susan E, Schnitt, Stuart J, Whitesell, Luke, Tamimi, Rulla M, Lindquist, Susan, Ince, Tan A

“…Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously…”
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Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression by Picon-Ruiz, Manuel, Pan, Chendong, Drews-Elger, Katherine, Jang, Kibeom, Besser, Alexandra H, Zhao, Dekuang, Morata-Tarifa, Cynthia, Kim, Minsoon, Ince, Tan A, Azzam, Diana J, Wander, Seth A, Wang, Bin, Ergonul, Burcu, Datar, Ram H, Cote, Richard J, Howard, Guy A, El-Ashry, Dorraya, Torné-Poyatos, Pablo, Marchal, Juan A, Slingerland, Joyce M

“…Consequences of the obesity epidemic on cancer morbidity and mortality are not fully appreciated. Obesity is a risk factor for many cancers, but the mechanisms…”
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Taxonomy of breast cancer based on normal cell phenotype predicts outcome by Santagata, Sandro, Thakkar, Ankita, Ergonul, Ayse, Wang, Bin, Woo, Terri, Hu, Rong, Harrell, J Chuck, McNamara, George, Schwede, Matthew, Culhane, Aedin C, Kindelberger, David, Rodig, Scott, Richardson, Andrea, Schnitt, Stuart J, Tamimi, Rulla M, Ince, Tan A

“…Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, a…”
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Chaperone-mediated autophagy degrades mutant p53 by Vakifahmetoglu-Norberg, Helin, Kim, Minsu, Xia, Hong-Guang, Iwanicki, Marcin P, Ofengeim, Dimitry, Coloff, Jonathan L, Pan, Lifeng, Ince, Tan A, Kroemer, Guido, Brugge, Joan S, Yuan, Junying

“…Missense mutations in the gene TP53, which encodes p53, one of the most important tumor suppressors, are common in human cancers. Accumulated mutant p53…”
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Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells by Elmasri, Harun, Karaaslan, Cagatay, Teper, Yaroslav, Ghelfi, Elisa, Weng, MeiQian, Ince, Tan A, Kozakewich, Harry, Bischoff, Joyce, Cataltepe, Sule

“…Fatty acid binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis. FABP4 has been primarily regarded as an adipocyte-…”
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VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells by Jang, Kibeom, Kim, Minsoon, Gilbert, Candace A, Simpkins, Fiona, Ince, Tan A, Slingerland, Joyce M

“…The angiogenic factor, VEGFA, is a therapeutic target in ovarian cancer (OVCA). VEGFA can also stimulate stem‐like cells in certain cancers, but mechanisms…”
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Transient commensal clonal interactions can drive tumor metastasis by Naffar-Abu Amara, Suha, Kuiken, Hendrik J., Selfors, Laura M., Butler, Timothy, Leung, Marco L., Leung, Cheuk T., Kuhn, Elaine P., Kolarova, Teodora, Hage, Carina, Ganesh, Kripa, Panayiotou, Richard, Foster, Rosemary, Rueda, Bo R., Aktipis, Athena, Spellman, Paul, Ince, Tan A., Xiu, Joanne, Oberley, Matthew, Gatalica, Zoran, Navin, Nicholas, Mills, Gordon B., Bronson, Rodrick T., Brugge, Joan S.

“…The extent and importance of functional heterogeneity and crosstalk between tumor cells is poorly understood. Here, we describe the generation of clonal…”
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Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin by McAllister, Sandra S., Gifford, Ann M., Greiner, Ashley L., Kelleher, Stephen P., Saelzler, Matthew P., Ince, Tan A., Reinhardt, Ferenc, Harris, Lyndsay N., Hylander, Bonnie L., Repasky, Elizabeth A., Weinberg, Robert A.

“…The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find…”
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C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer by Razavipour, Seyedeh Fatemeh, Yoon, Hyunho, Jang, Kibeom, Kim, Minsoon, Nawara, Hend M., Bagheri, Amir, Huang, Wei-Chi, Shin, Miyoung, Zhao, Dekuang, Zhou, Zhiqun, Van Boven, Derek, Briegel, Karoline, Morey, Lluis, Ince, Tan A., Johnson, Michael, Slingerland, Joyce M.

“…In many cancers, a stem-like cell subpopulation mediates tumor initiation, dissemination and drug resistance. Here, we report that cancer stem cell (CSC)…”
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Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes by Ince, Tan A., Richardson, Andrea L., Bell, George W., Saitoh, Maki, Godar, Samuel, Karnoub, Antoine E., Iglehart, James D., Weinberg, Robert A.

“…We investigated the influence of normal cell phenotype on the neoplastic phenotype by comparing tumors derived from two different normal human mammary…”
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Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression by Godar, Samuel, Ince, Tan A., Bell, George W., Feldser, David, Donaher, Joana Liu, Bergh, Jonas, Liu, Anne, Miu, Kevin, Watnick, Randolph S., Reinhardt, Ferenc, McAllister, Sandra S., Jacks, Tyler, Weinberg, Robert A.

“…The p53 tumor suppressor is a key mediator of cellular responses to various stresses. Here, we show that under conditions of basal physiologic and cell-culture…”
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Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer by Jacks, Tyler, Dinulescu, Daniela M, Ince, Tan A, Quade, Bradley J, Shafer, Sarah A, Crowley, Denise

“…Epithelial ovarian tumors present a complex clinical, diagnostic and therapeutic challenge because of the difficulty of early detection, lack of known…”
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