Search Results - "Ince, Francis"

From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis by SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G

“…Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described…”
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QSAR and the Rational Design of Long-Acting Dual D2-Receptor/β2-Adrenoceptor Agonists by Austin, Rupert P, Barton, Patrick, Bonnert, Roger V, Brown, Roger C, Cage, Peter A, Cheshire, David R, Davis, Andrew M, Dougall, Iain G, Ince, Francis, Pairaudeau, Garry, Young, Alan

“…This paper describes the development of a QSAR model for the rational control of functional duration of topical long-acting dual D2-receptor/β2-adrenoceptor…”
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From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis by Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.

“…Starting with ATP, the identification of novel P2Y 12 receptor antagonists are described. The leading compound, 17 (AZD6140), is currently in a phase III…”
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QSAR and the rational design of long-acting dual D2-receptor/beta 2-adrenoceptor agonists by Austin, Rupert P, Barton, Patrick, Bonnert, Roger V, Brown, Roger C, Cage, Peter A, Cheshire, David R, Davis, Andrew M, Dougall, Iain G, Ince, Francis, Pairaudeau, Garry, Young, Alan

“…This paper describes the development of a QSAR model for the rational control of functional duration of topical long-acting dual…”
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QSAR and the Rational Design of Long-Acting Dual D 2 -Receptor/β 2 -Adrenoceptor Agonists by Austin, Rupert P., Barton, Patrick, Bonnert, Roger V., Brown, Roger C., Cage, Peter A., Cheshire, David R., Davis, Andrew M., Dougall, Iain G., Ince, Francis, Pairaudeau, Garry, Young, Alan

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Dual D2-Receptor and β2-Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3H)-one Analogues by Bonnert, Roger V, Brown, Roger C, Chapman, David, Cheshire, David R, Dixon, John, Ince, Francis, Kinchin, Elizabeth C, Lyons, Amanda J, Davis, Andrew M, Hallam, Catherine, Harper, Stephen T, Unitt, John F, Dougall, Iain G, Jackson, Dale M, McKechnie, Kenneth, Young, Alan, Simpson, Wilfred T

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Novel cobalt complex inhibitors of mitochondrial calcium uptake by UNITT, J. F, BODEN, K. L, WALLACE, A. V, INGALL, A. H, COOMBS, M. E, INCE, F

“…Reperfusion of the ischaemic myocardium leads to intracellular calcium overload followed by mitochondrial dysfunction, resulting in insufficient energy supply…”
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Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogs: the first examples of a new class of calcium channel activator by Baxter, Andrew J. G, Dixon, John, Ince, Francis, Manners, Carol N, Teague, Simon J

“…Methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate, FPL 64176 (1), is the first example of a new class of calcium channel activator (CCA)…”
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Dual D 2 -Receptor and β 2 -Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3 H )-one Analogues by Bonnert, Roger V., Brown, Roger C., Chapman, David, Cheshire, David R., Dixon, John, Ince, Francis, Kinchin, Elizabeth C., Lyons, Amanda J., Davis, Andrew M., Hallam, Catherine, Harper, Stephen T., Unitt, John F., Dougall, Iain G., Jackson, Dale M., McKechnie, Kenneth, Young, Alan, Simpson, Wilfred T.

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The medicinal chemistry of the P2 receptor family by Guile, S D, Ince, F, Ingall, A H, Kindon, N D, Meghani, P, Mortimore, M P

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