Search Results - "Inamori, Kei‐Ichiro"

Dystroglycan Function Requires Xylosyl- and Glucuronyltransferase Activities of LARGE by Inamori, Kei-ichiro, Yoshida-Moriguchi, Takako, Hara, Yuji, Anderson, Mary E., Yu, Liping, Campbell, Kevin P.

“…Posttranslational modification of alpha-dystroglycan (α-DG) by the like-acetylglucosaminyltransferase (LARGE) is required for it to function as an…”
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Homeostatic and pathogenic roles of the GM3 ganglioside by Inokuchi, Jin‐ichi, Kanoh, Hirotaka, Inamori, Kei‐ichiro, Nagafuku, Masakazu, Nitta, Takahiro, Fukase, Koichi

“…Two decades ago, we achieved molecular cloning of ganglioside GM3 synthase (GM3S; ST3GAL5), the enzyme responsible for initiating biosynthesis of complex…”
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Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors by Takeda, Kazuya, Kaifu, Tomonori, Michihata, Ryunosuke, Kinugawa, Naotaka, Fujioka, Atushi, Tateno, Ayaka, Toshima, Kaoru, Kanoh, Hirotaka, Inamori, Kei‐Ichiro, Kamijo, Keiju, Himeda, Toshiki, Ohara, Yoshiro, Inokuchi, Jin‐Ichi, Nakamura, Akira

“…Theiler's murine encephalomyelitis virus (TMEV) causes a chronic demyelinating disease similar to multiple sclerosis in mice. Although sialic acids have been…”
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Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity by Kanoh, Hirotaka, Nitta, Takahiro, Go, Shinji, Inamori, Kei‐ichiro, Veillon, Lucas, Nihei, Wataru, Fujii, Mayu, Kabayama, Kazuya, Shimoyama, Atsushi, Fukase, Koichi, Ohto, Umeharu, Shimizu, Toshiyuki, Watanabe, Taku, Shindo, Hiroki, Aoki, Sorama, Sato, Kenichi, Nagasaki, Mika, Yatomi, Yutaka, Komura, Naoko, Ando, Hiromune, Ishida, Hideharu, Kiso, Makoto, Natori, Yoshihiro, Yoshimura, Yuichi, Zonca, Asia, Cattaneo, Anna, Letizia, Marilena, Ciampa, Maria, Mauri, Laura, Prinetti, Alessandro, Sonnino, Sandro, Suzuki, Akemi, Inokuchi, Jin‐ichi

“…Innate immune signaling via TLR4 plays critical roles in pathogenesis of metabolic disorders, but the contribution of different lipid species to metabolic…”
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Roles of Gangliosides in Hypothalamic Control of Energy Balance: New Insights by Inamori, Kei-Ichiro, Inokuchi, Jin-Ichi

“…Gangliosides are essential components of cell membranes and are involved in a variety of physiological processes, including cell growth, differentiation, and…”
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Mass Spectrometry of Neutral Glycosphingolipids by Suzuki, Akemi, Silsirivanit, Atit, Watanabe, Takashi, Matsuda, Junko, Inamori, Kei-Ichiro, Inokuchi, Jin-Ichi

“…This chapter describes the protocols for mass spectrometry (MS) applied to the structural characterization of neutral glycosphingolipids (GSLs) and the…”
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Sialyltransferase Activity Assay for Ganglioside GM3 Synthase by Inamori, Kei-Ichiro, Nitta, Takahiro, Shishido, Fumi, Watanabe, Soichiro, Ohno, Isao, Inokuchi, Jin-Ichi

“…GM3 synthase (GM3S) is a sialyltransferase that transfers sialic acid from CMP-sialic acid to lactosylceramide. This reaction results in formation of…”
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The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation by Willer, Tobias, Inamori, Kei-Ichiro, Venzke, David, Harvey, Corinne, Morgensen, Greg, Hara, Yuji, Beltrán Valero de Bernabé, Daniel, Yu, Liping, Wright, Kevin M, Campbell, Kevin P

“…Dystroglycan is a cell membrane receptor that organizes the basement membrane by binding ligands in the extracellular matrix. Proper glycosylation of the…”
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Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice by Inamori, Kei-ichiro, Ito, Hideki, Tamura, Yumi, Nitta, Takahiro, Yang, Xiaohua, Nihei, Wataru, Shishido, Fumi, Imazu, Susumu, Tsukita, Sohei, Yamada, Tetsuya, Katagiri, Hideki, Inokuchi, Jin-ichi

“…GM3, a precursor for synthesis of a- and b-series gangliosides, is elevated in adipocytes of obese model animals and in sera of obese human patients with type…”
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Functional validation of novel variants in B4GALNT1 associated with early‐onset complex hereditary spastic paraplegia with impaired ganglioside synthesis by Alecu, Julian Emanuel, Ohmi, Yuhsuke, Bhuiyan, Robiul H., Inamori, Kei‐ichiro, Nitta, Takahiro, Saffari, Afshin, Jumo, Hellen, Ziegler, Marvin, Gusmao, Claudio Melo, Sharma, Nutan, Ohno, Shiho, Manabe, Noriyoshi, Yamaguchi, Yoshiki, Kambe, Mariko, Furukawa, Keiko, Sahin, Mustafa, Inokuchi, Jin‐ichi, Furakawa, Koichi, Ebrahimi‐Fakhari, Darius

“…Childhood‐onset forms of hereditary spastic paraplegia are ultra‐rare diseases and often present with complex features. Next‐generation‐sequencing allows for…”
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NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains by Nihei, Wataru, Nagafuku, Masakazu, Hayamizu, Hirotaka, Odagiri, Yuta, Tamura, Yumi, Kikuchi, Yui, Veillon, Lucas, Kanoh, Hirotaka, Inamori, Kei-ichiro, Arai, Kenta, Kabayama, Kazuya, Fukase, Koichi, Inokuchi, Jin-ichi

“…Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to…”
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Neurological insights on two siblings with GM3 synthase deficiency due to novel compound heterozygous ST3GAL5 variants by Watanabe, Shiena, Lei, Ming, Nakagawa, Eiji, Takeshita, Eri, Inamori, Kei-Ichiro, Shishido, Fumi, Sasaki, Masayuki, Mitsuhashi, Satomi, Matsumoto, Naomichi, Kimura, Yuiko, Iwasaki, Masaki, Takahashi, Yuji, Mizusawa, Hidehiro, Migita, Ohsuke, Ohno, Isao, Inokuchi, Jin-ichi

“…ST3GAL5 encodes GM3 synthase (ST3 beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL5), which synthesizes GM3 by transferring sialic acid to…”
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Role of dystroglycan in limiting contraction-induced injury to the sarcomeric cytoskeleton of mature skeletal muscle by Rader, Erik P., Turk, Rolf, Willer, Tobias, Beltrán, Daniel, Inamori, Kei-ichiro, Peterson, Taylor A., Engle, Jeffrey, Prouty, Sally, Matsumura, Kiichiro, Saito, Fumiaki, Anderson, Mary E., Campbell, Kevin P.

“…Dystroglycan (DG) is a highly expressed extracellular matrix receptor that is linked to the cytoskeleton in skeletal muscle. DG is critical for the function of…”
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GM3 synthase deficiency increases brain glucose metabolism in mice by Bharathi, Sivakama S., Zhang, Bob B., Paul, Eli, Zhang, Yuxun, Schmidt, Alexandra V., Fowler, Benjamin, Wu, Yijen, Tiemeyer, Michael, Inamori, Kei-ichiro, Inokuchi, Jin-ichi, Goetzman, Eric S.

“…GM3 synthase (GM3S) deficiency is a rare neurodevelopmental disorder caused by an inability to synthesize gangliosides, for which there is currently no…”
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N-Acetylglucosaminyltransferase III Antagonizes the Effect of N-Acetylglucosaminyltransferase V on α3β1 Integrin-mediated Cell Migration by Zhao, Yanyang, Nakagawa, Takatoshi, Itoh, Satsuki, Inamori, Kei-ichiro, Isaji, Tomoya, Kariya, Yoshinobu, Kondo, Akihiro, Miyoshi, Eiji, Miyazaki, Kaoru, Kawasaki, Nana, Taniguchi, Naoyuki, Gu, Jianguo

“…N-Acetylglucosaminyltransferase V (GnT-V) catalyzes the addition of β1,6-GlcNAc branching of N-glycans, which contributes to metastasis…”
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N-Acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of α5β1 Integrin by Yamamoto, Eiko, Ino, Kazuhiko, Miyoshi, Eiji, Inamori, Kei-ichiro, Abe, Akihiro, Sumigama, Seiji, Iwase, Akira, Kajiyama, Hiroaki, Shibata, Kiyosumi, Nawa, Akihiro, Kikkawa, Fumitaka

“…For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential, and the regulation of this…”
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A Serine Protease Zymogen Functions as a Pattern-Recognition Receptor for Lipopolysaccharides by Ariki, Shigeru, Koori, Kumiko, Osaki, Tsukasa, Motoyama, Kiyohito, Inamori, Kei-ichiro, Kawabata, Shun-ichiro

“…Bacterial lipopolysaccharide (LPS)-induced exocytosis of granular hemocytes is a key component of the horseshoe crab's innate immunity to infectious…”
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A Toll-like receptor in horseshoe crabs by Inamori, Kei-ichiro, Ariki, Shigeru, Kawabata, Shun-ichiro

“…Non‐self‐recognition of invading microbes relies on the pattern‐recognition of pathogen‐associated molecular patterns (PAMPs) derived from microbial cell‐wall…”
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Ganglioside GM3 Synthase Deficiency in Mouse Models and Human Patients by Inamori, Kei-Ichiro, Inokuchi, Jin-Ichi

“…Gangliosides (glycosphingolipids containing one or more sialic acids) are highly expressed in neural tissues in vertebrates, and four species (GM1a, GD1a,…”
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LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans by Inamori, Kei-ichiro, Beedle, Aaron M., de Bernabé, Daniel Beltrán-Valero, Wright, Michael E., Campbell, Kevin P.

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