Search Results - "Inagaki, Shinobu"

FOXO1 represses lymphatic valve formation and maintenance via PRDM1 by Niimi, Kenta, Nakae, Jun, Inagaki, Shinobu, Furuyama, Tatsuo

“…Intraluminal lymphatic valves (LVs) contribute to the prevention of lymph backflow and maintain circulatory homeostasis. Several reports have investigated the…”
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Ultrasonic Evaluation of the Heel Fat Pad Under Loading Conditions Using a Polymethylpentene Resin Plate: Part 2. Reliability and Agreement Study by Matsumoto, Masatomo, Maemichi, Toshihiro, Wada, Mitsunari, Niwa, Yuki, Inagaki, Shinobu, Taguchi, Atsuya, Okunuki, Takumi, Tanaka, Hirofumi, Kumai, Tsukasa

“…Previously, we developed an instrument to evaluate the heel fat pad (HFP) two-layer structure, under varying loading conditions, with ultrasonography from the…”
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Ultrasonic Evaluation of the Heel Fat Pad under Weight-Bearing Conditions Using a Polymethylpentene Resin Plate: Part 1 by Matsumoto, Masatomo, Maemichi, Toshihiro, Wada, Mitsunari, Niwa, Yuki, Inagaki, Shinobu, Okunuki, Takumi, Ichikawa, Shota, Kumai, Tsukasa

“…To evaluate the two-layer structure of the heel fat pad (HFP) from non-weight-bearing to full-weight-bearing conditions, we developed an instrument that…”
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Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina by Niimi, Kenta, Adachi, Yumi, Ishikawa, Hiroko, Yamaguchi, Wataru, Kubota, Yoshiaki, Inagaki, Shinobu, Furuyama, Tatsuo

“…Pericytes are mural cells that cover small blood vessels. While defects in pericyte coverage are known to be involved in various vessel related pathologies,…”
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FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis by Niimi, Kenta, Kohara, Misaki, Sedoh, Eriko, Fukumoto, Moe, Shibata, Satoshi, Sawano, Toshinori, Tashiro, Fumi, Miyazaki, Satsuki, Kubota, Yoshiaki, Miyazaki, Jun-Ichi, Inagaki, Shinobu, Furuyama, Tatsuo

“…Lymphangiogenesis plays important roles in normal fetal development and postnatal growth. However, its molecular regulation remains unclear. Here, we have…”
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Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas by Fukumoto, Moe, Kondo, Kanako, Uni, Kazumasa, Ishiguro, Tomoko, Hayashi, Mikiko, Ueda, Shinnosuke, Mori, Itsuki, Niimi, Kenta, Tashiro, Fumi, Miyazaki, Satsuki, Miyazaki, Jun-Ichi, Inagaki, Shinobu, Furuyama, Tatsuo

“…Forkhead box protein O1 (FoxO1) is a transcription factor and a critical regulator of angiogenesis. Various environmental stimuli, including growth factors,…”
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Effect of Sema4D on microglial function in middle cerebral artery occlusion mice by Sawano, Toshinori, Watanabe, Fumiya, Ishiguchi, Mitsuko, Doe, Nobutaka, Furuyama, Tatsuo, Inagaki, Shinobu

“…Cerebral ischemia evokes neuroinflammatory response. Inflammatory stimulation induces microglial activation, such as changes of their morphology from ramified…”
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Transcription factor FOXO1 promotes cell migration toward exogenous ATP via controlling P2Y1 receptor expression in lymphatic endothelial cells by Niimi, Kenta, Ueda, Mizuha, Fukumoto, Moe, Kohara, Misaki, Sawano, Toshinori, Tsuchihashi, Ryo, Shibata, Satoshi, Inagaki, Shinobu, Furuyama, Tatsuo

“…Sprouting migration of lymphatic endothelial cell (LEC) is a pivotal step in lymphangiogenic process. However, its molecular mechanism remains unclear…”
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Homology analysis detects topological changes of Iba1 localization accompanied by microglial activation by Sawano, Toshinori, Tsuchihashi, Ryo, Morii, Eiichi, Watanabe, Fumiya, Nakane, Kazuaki, Inagaki, Shinobu

“…Highlights • Microglial activation induces topological change of Iba1 localization. • Topological change of Iba1 is detectable by analysis based on homology…”
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Sema4D as an inhibitory regulator in oligodendrocyte development by Yamaguchi, Wataru, Tamai, Rie, Kageura, Miho, Furuyama, Tatsuo, Inagaki, Shinobu

“…The specific functions of intrinsic regulators of OL differentiation are poorly understood. Sema4D, originally found as a negative regulator of axon guidance,…”
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Detection of novel visible-light region absorbance peaks in the urine after alkalization in patients with alkaptonuria by Tokuhara, Yasunori, Shukuya, Kenichi, Tanaka, Masami, Mouri, Mariko, Ohkawa, Ryunosuke, Fujishiro, Midori, Takahashi, Tomoo, Okubo, Shigeo, Yokota, Hiromitsu, Kurano, Makoto, Ikeda, Hitoshi, Yamaguchi, Seiji, Inagaki, Shinobu, Ishige-Wada, Mika, Usui, Hiromi, Yatomi, Yutaka, Shimosawa, Tatsuo

“…Alkaptonuria, caused by a deficiency of homogentisate 1,2-dioxygenase, results in the accumulation of homogentisic acid (2,5-dihydroxyphenylacetic acid, HGA)…”
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Physical and Functional Interactions of the Lysophosphatidic Acid Receptors with PDZ Domain-containing Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by Yamada, Takeshi, Ohoka, Yoshiharu, Kogo, Mikihiko, Inagaki, Shinobu

“…Lysophosphatidic acid (LPA) is a serum-derived phospholipid that induces a variety of biological responses in various cells via heterotrimeric G…”
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Identification of a Negative Regulatory Region for the Exchange Activity and Characterization of T332I Mutant of Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10) by Chaya, Taro, Shibata, Satoshi, Tokuhara, Yasunori, Yamaguchi, Wataru, Matsumoto, Hiroshi, Kawahara, Ichiro, Kogo, Mikihiko, Ohoka, Yoshiharu, Inagaki, Shinobu

“…The T332I mutation in Rho guanine nucleotide exchange factor 10 (ARHGEF10) was previously found in persons with slowed nerve conduction velocities and thin…”
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Absence of Sema4D improves oligodendrocyte recovery after cerebral ischemia/reperfusion injury in mice by Wada, Takenobu, Sawano, Toshinori, Tanaka, Takashi, Furuyama, Tatsuo, Fukumoto, Moe, Yamaguchi, Wataru, Saino, Orie, Takeda, Yuichi, Kogo, Mikihiko, Matsuyama, Tomohiro, Inagaki, Shinobu

“…•The effect of Sema4D-deficiency on oligodendrocyte was studied in mice.•Direct ligation of the middle cerebral artery and reperfusion were employed.•The…”
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Sema4D deficiency results in an increase in the number of oligodendrocytes in healthy and injured mouse brains by Taniguchi, Yoshitaka, Amazaki, Mayumi, Furuyama, Tatsuo, Yamaguchi, Wataru, Takahara, Mizue, Saino, Orie, Wada, Takeshi, Niwa, Hitoshi, Tashiro, Fumi, Miyazaki, Jun-ichi, Kogo, Mikihiko, Matsuyama, Tomohiro, Inagaki, Shinobu

“…Semaphorins, a family of secreted and membrane‐bound proteins, are known to function as repulsive axon guidance molecules. Sema4D, a class 4 transmembrane‐type…”
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A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis by Korostylev, Alexander, Worzfeld, Thomas, Deng, Suhua, Friedel, Roland H, Swiercz, Jakub M, Vodrazka, Peter, Maier, Viola, Hirschberg, Alexandra, Ohoka, Yoshiharu, Inagaki, Shinobu, Offermanns, Stefan, Kuner, Rohini

“…Semaphorins and their receptors, plexins, carry out important functions during development and disease. In contrast to the well-characterized plexin A family,…”
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Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones by Masuda, Kenta, Furuyama, Tatsuo, Takahara, Mizue, Fujioka, Shiho, Kurinami, Hitomi, Inagaki, Shinobu

“…Several semaphorins are thought to function as potent inhibitors of axonal growth. We have found that Sema4D stimulates axonal outgrowth of embryonic dorsal…”
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Clinical Assessment of Mental Rotation in Hemiplegic Patients after Stroke by Tanaka, Takashi, Yamada, Minoru, Inagaki, Shinobu

“…[Purpose] In this study, we investigated the motor imagery ability of hemiplegic stroke patients. [Subjects] The subjects were 29 healthy individuals (average…”
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Requirement of the transmembrane semaphorin Sema4C for myogenic differentiation by Ko, Ji-Ae, Gondo, Toshikazu, Inagaki, Shinobu, Inui, Makoto

“…Semaphorins constitute a large family of signaling proteins that contribute to axonal guidance. Here we demonstrate that the transmembrane semaphorin Sema4C is…”
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Macrophages play a crucial role in vascular smooth muscle cell coverage by Niimi, Kenta, Nakae, Jun, Kubota, Yoshiaki, Inagaki, Shinobu, Furuyama, Tatsuo

“…The microvascular system consists of two cell types: endothelial and mural (pericytes and vascular smooth muscle cells; VSMCs) cells. Communication between…”
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