Monocyte Chemoattractant Protein-1 (MCP-1) as a Potential Therapeutic Target and a Noninvasive Biomarker of Liver Fibrosis Associated With Transient Myeloproliferative Disorder in Down Syndrome

Liver fibrosis is one of the common complications of transient myeloproliferative disorder (TMD) in Down syndrome (DS), but the exact molecular pathogenesis is largely unknown. We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cy...

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Published in:	Journal of pediatric hematology/oncology Vol. 39; no. 5; pp. e285 - e289
Main Authors:	Kobayashi, Kenichiro, Yoshioka, Takako, Miyauchi, Jun, Nakazawa, Atsuko, Yamazaki, Shigeaki, Ono, Hiromi, Tatsuno, Michiko, Iijima, Kenta, Takahashi, Chiaki, Okada, Yoko, Teranishi, Kenji, Matsunaga, Takaaki, Matsushima, Chieko, Inagaki, Mayo, Suehiro, Minoru, Suehiro, Saori, Nishitani, Masahiko, Kubota, Hirohito, Iio, Jun, Nishida, Yoshinobu, Katayama, Tetsuo, Takada, Narito, Watanabe, Kentaro, Yamamoto, Tetsuro, Yasumizu, Ryoji, Matsuoka, Kentaro, Ohki, Kentaro, Kiyokawa, Nobutaka, Maihara, Toshiro, Usami, Ikuya
Format:	Journal Article
Language:	English
Published:	United States 01-07-2017
Subjects:	Biomarkers Chemokine CCL2 - analysis Cytokines - analysis Diagnosis, Differential Down Syndrome - complications Humans Infant, Newborn Leukemoid Reaction - complications Liver - chemistry Liver - pathology Liver Cirrhosis - diagnosis Liver Cirrhosis - etiology
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Summary:	Liver fibrosis is one of the common complications of transient myeloproliferative disorder (TMD) in Down syndrome (DS), but the exact molecular pathogenesis is largely unknown. We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cytokines analyses. We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. We also showed a prospective of the future anticytokine therapy with herbal medicine for the liver fibrosis associated with TMD in DS.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1077-4114 1536-3678
DOI:	10.1097/MPH.0000000000000809