Search Results - "Inagaki, Hiroaki"

Two distinct EF-Tu epitopes induce immune responses in rice and Arabidopsis by Furukawa, Takehito, Inagaki, Hiroaki, Takai, Ryota, Hirai, Hiroyuki, Che, Fang-Sik

“…Plants sense potential pathogens by recognizing conserved pathogen-associated molecular patterns (PAMPs) that cause PAMP-triggered immunity (PTI). We…”
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Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones by Komoriya, Satoshi, Odagiri, Takashi, Inagaki, Hiroaki, Nagamochi, Masatoshi, Miyauchi, Rie, Yoshida, Ken-ichi, Kitamura, Takahiro, Takahashi, Hisashi

“…A series of 8-methoxy or 8-methylquinolones bearing novel 3-aminooctahydrocyclopenta[c]pyrrole derivatives at the C-7 position was synthesized, and the…”
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Novel Peptidomimetics of the Antifungal Cyclic Peptide Rhodopeptin:  Design of Mimetics Utilizing Scaffolding Methodology by Nakayama, Kiyoshi, Kawato, Haruko C, Inagaki, Hiroaki, Ohta, Toshiharu

“…Novel nonpeptide peptidomimetics of the antifungal cyclic peptide Rhodopeptin were designed utilizing hydantoin, benzimidazole, d-glucosamine, quinolone, and…”
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Design, Synthesis, and Biological Evaluation of Novel 7‑[(3aS,7aS)‑3a‑Aminohexahydropyrano[3,4‑c]pyrrol-2(3H)‑yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens by Odagiri, Takashi, Inagaki, Hiroaki, Nagamochi, Masatoshi, Kitamura, Takahiro, Komoriya, Satoshi, Takahashi, Hisashi

“…Novel 7-[(3aS,7aS)-3a-aminohexahydropyrano­[3,4-c]­pyrrol-2­(3H)-yl]-6-fluoro-1-[(1R,2S)-2-…”
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Practical Synthesis of DQ-113, a New Quinolone Antibacterial Agent, by Using the Intramolecular Horner-Wadsworth- Emmons Reaction by Inagaki, Hiroaki, Takeda, Toshiyuki, N. Miyauchi, Rie, Kawakami, Katsuhiro, Takahashi, Hisashi, Takemura, Makoto

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Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581 by Taniguchi, Toru, Yasumatsu, Isao, Inagaki, Hiroaki, Baba, Daichi, Toyota, Akiko, Kaneta, Yasuyuki, Odagiri, Takashi, Momose, Takayuki, Kawai, Junya, Imaoka, Tomoki, Nakayama, Kiyoshi

“…Previously, we reported the new pyrido-pyridazinone template as a feline sarcoma-related (FER) tyrosine kinase inhibitor. Representative compound 1…”
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Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor by McNamara, Blair, Harold, Justin, Manavella, Diego, Bellone, Stefania, Mutlu, Levent, Hartwich, Tobias Max Philipp, Zipponi, Margherita, Yang-Hartwich, Yang, Demirkiran, Cem, Verzosa, Miguel Skyler Z., Yang, Kevin, Choi, Jungmin, Dong, Weilai, Buza, Natalia, Hui, Pei, Altwerger, Gary, Huang, Gloria S., Andikyan, Vaagn, Clark, Mitchell, Ratner, Elena, Azodi, Masoud, Schwartz, Peter E., Burton, Elizabeth A., Inagaki, Hiroaki, Albers, Aaron, Zhang, Chao, Bollag, Gideon, Schlessinger, Joseph, Santin, Alessandro D.

“…Uterine leiomyosarcomas (uLMS) are rare, highly aggressive tumors. Up to 30% of uLMS may harbor gain of function (GOF) in the MAP2K4 gene, important for tumor…”
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Design, Synthesis, and Biological Evaluation of Novel 8-Methoxyquinolones Bearing Fused Pyrrolidinyl Moieties at the C-7 Position with Potent Antibacterial Activity Against Respiratory Pathogens by Odagiri, Takashi, Inagaki, Hiroaki, Kitamura, Takahiro, Komoriya, Satoshi, Takahashi, Hisashi

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Design, Synthesis, and Biological Evaluations of Novel 7‑[7-Amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens by Odagiri, Takashi, Inagaki, Hiroaki, Sugimoto, Yuichi, Nagamochi, Masatoshi, Miyauchi, Rie N, Kuroyanagi, Junichi, Kitamura, Takahiro, Komoriya, Satoshi, Takahashi, Hisashi

“…Novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]- 8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 2a and…”
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Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity by Taniguchi, Toru, Inagaki, Hiroaki, Baba, Daichi, Yasumatsu, Isao, Toyota, Akiko, Kaneta, Yasuyuki, Kiga, Masaki, Iimura, Shin, Odagiri, Takashi, Shibata, Yoshihiro, Ueda, Kiyono, Seo, Maki, Shimizu, Hiroki, Imaoka, Tomoki, Nakayama, Kiyoshi

“…To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1,…”
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Improved synthesis of DQ-113, a new quinolone antibacterial agent, utilizing the Reformatsky reaction by Inagaki, Hiroaki, Sugita, Kazuyuki, Miyauchi, Rie N., Miyauchi, Satoru, Takeda, Toshiyuki, Itoh, Masao, Takahashi, Hisashi, Takemura, Makoto

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Abstract B173: Preclinical characterization and antitumor efficacy of DS-5010, a highly potent and selective RET inhibitor by Kaneta, Yasuyuki, Komatsu, Takahiro, Miyamoto, Masashi, Goto, Megumi, Namiki, Hidenori, Shibata, Yoshihiro, Kageji, Hideaki, Inagaki, Hiroaki, Nakayama, Kiyoshi, Tominaga, Yuichi, Isoyama, Takeshi

“…Abstract Background: RET gene rearrangement has been detected in several cancers including 1-2% and 50% of non-small cell lung cancer (NSCLC) and papillary…”
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Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria by Miyauchi, Rie, Kawakami, Katsuhiro, Ito, Masao, Matsuhashi, Norikazu, Ohki, Hitoshi, Inagaki, Hiroaki, Takahashi, Hisashi, Takemura, Makoto

“…A series of novel 6-desfluoro [des-F(6)] and 6-fluoro-1-[(1 R,2 S)-2-fluorocyclopropan-1-yl]-8-methoxyquinolones bearing 3-(1-aminocycloalkyl)pyrrolidin-1-yl…”
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Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode by Inagaki, Hiroaki, Tsuruoka, Hiroyuki, Hornsby, Michael, Lesley, Scott A, Spraggon, Glen, Ellman, Jonathan A

“…The substrate activity screening (SAS) method, a substrate-based fragment identification and optimization method for the development of enzyme inhibitors, was…”
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Synthesis and Antifungal Activity of Rhodopeptin Analogues. 2. Modification of the West Amino Acid Moiety by Nakayama, Kiyoshi, Kawato, Haruko C, Inagaki, Hiroaki, Nakajima, Ryohei, Kitamura, Akihiro, Someya, Kazuhiko, Ohta, Toshiharu

“…Structure−activity relationships of the west amino acid modified analogues of rhodopeptins, novel antifungal tetrapeptide isolated from Rhodococcus species…”
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Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position by Inagaki, Hiroaki, Takahashi, Hisashi, Takemura, Makoto

“…New quinolone compounds were synthesized and evaluated their antibacterial activity and enzyme selectivity. A series of novel…”
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Synthesis and Structure−Activity Relationships of 5-Amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic Acid Antibacterials Having Fluorinated 7-[(3R)-3-(1-Aminocyclopropan-1-yl)pyrrolidin-1-yl] Substituents by Inagaki, Hiroaki, Miyauchi, Satoru, Miyauchi, Rie N, Kawato, Haruko C, Ohki, Hitoshi, Matsuhashi, Norikazu, Kawakami, Katsuhiro, Takahashi, Hisashi, Takemura, Makoto

“…A series of novel 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolones bearing fluorinated (3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl…”
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Novel Peptidomimetics of the Antifungal Cyclic Peptide Rhodopeptin:  Synthesis of Mimetics and Their Antifungal Activity by Kawato, Haruko C, Nakayama, Kiyoshi, Inagaki, Hiroaki, Ohta, Toshiharu

“…Novel peptidomimetics of the antifungal cyclic peptide Rhodopeptin were synthesized. As with the cyclic peptides, the presence of all three Rhodopeptin side…”
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Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R, 2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxyli c acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents by INAGAKI, Hiroaki, MIYAUCHI, Satoru, MIYAUCHI, Rie N, KAWATO, Haruko C, OHKI, Hitoshi, MATSUHASHI, Norikazu, KAWAKAMI, Katsuhiro, TAKAHASHI, Hisashi, TAKEMURA, Makoto

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Synthesis and Antifungal Activity of Rhodopeptin Analogues. 1. Modification of the East and South Amino Acid Moieties by Kawato, Haruko C, Nakayama, Kiyoshi, Inagaki, Hiroaki, Nakajima, Ryohei, Kitamura, Akihiro, Someya, Kazuhiko, Ohta, Toshiharu

“…Structure−activity relationships of the east and south amino acid modified analogues of rhodopeptins, novel antifungal cyclic tetrapeptides isolated from…”
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