Search Results - "Inagaki, Akihito"

Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells by Soeda, Akio, Inagaki, Akihito, Oka, Naoki, Ikegame, Yuka, Aoki, Hitomi, Yoshimura, Shin-ichi, Nakashima, Shigeru, Kunisada, Takahiro, Iwama, Toru

“…A cancer stem cell population in malignant brain tumors takes an essential part in brain tumor initiation, growth, and recurrence. Growth factors, such as…”
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Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity by Hiraoka, Kei, Inagaki, Akihito, Kato, Yuki, Huang, Tiffany T, Mitchell, Leah A, Kamijima, Shuichi, Takahashi, Masamichi, Matsumoto, Hiroshi, Hacke, Katrin, Kruse, Carol A, Ostertag, Derek, Robbins, Joan M, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki

“…Prodrug-activator gene therapy with Toca 511, a tumor-selective retroviral replicating vector (RRV) encoding yeast cytosine deaminase, is being evaluated in…”
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Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer by Inoko, Kazuho, Hiraoka, Kei, Inagaki, Akihito, Takahashi, Mizuna, Kushibiki, Toshihiro, Hontani, Koji, Takano, Hironobu, Sato, Shoki, Takeuchi, Shintaro, Nakamura, Toru, Tsuchikawa, Takahiro, Shichinohe, Toshiaki, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki, Hirano, Satoshi

“…Toca 511, a retroviral replicating vector (RRV) encoding the yeast cytosine deaminase (yCD) prodrug activator gene, which mediates conversion of the prodrug…”
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Epithelial Membrane Protein-2 (EMP2) Activates Src Protein and Is a Novel Therapeutic Target for Glioblastoma by Qin, Yu, Fu, Maoyong, Takahashi, Masamichi, Iwanami, Akio, Kuga, Daisuke, Rao, Rajiv G., Sudhakar, Deepthi, Huang, Tiffany, Kiyohara, Meagan, Torres, Kathleen, Dillard, Christen, Inagaki, Akihito, Kasahara, Noriyuki, Goodglick, Lee, Braun, Jonathan, Mischel, Paul S., Gordon, Lynn K., Wadehra, Madhuri

“…Despite recent advances in molecular classification, surgery, radiotherapy, and targeted therapies, the clinical outcome of patients with malignant brain…”
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PET imaging for gene & cell therapy by Collins, Sara A, Hiraoka, Kei, Inagaki, Akihito, Kasahara, Noriyuki, Tangney, Mark

“…As the interest in gene therapy increases, the development of an efficient and reliable means to monitor gene delivery and expression in patients is becoming…”
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Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions by Inagaki, Akihito, Soeda, Akio, Oka, Naoki, Kitajima, Hideomi, Nakagawa, Jiro, Motohashi, Tsutomu, Kunisada, Takahiro, Iwama, Toru

“…There is increasing evidence for the presence of cancer stem-like progenitors in malignant brain tumors. This subpopulation of progenitor cells, the so-called…”
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EXTH-33. RETROVIRAL REPLICATING VECTORS PSEUDOTYPED WITH GIBBON APE LEUKEMIA VIRUS ENVELOPE FOR PRODRUG ACTIVATOR GENE THERAPY IN PRECLINICAL GLIOMA MODELS by Inagaki, Akihito, Collins, Sara, Freedman, Alicia, Montoya, Megan, Haddad, Alexander, Barcova, Maria, Kasahara, Noriyuki

“…Amphotropic retroviral replicating vector (RRV) Toca 511, expressing the yeast cytosine deaminase (CD) prodrug activator gene, showed promising evidence of…”
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Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model by Mitchell, Leah A, Lopez Espinoza, Fernando, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M

“…Toca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD…”
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EXTH-44. DEVELOPMENT OF RETROVIRAL REPLICATING VECTORS ENCODING SEQUENCE-OPTIMIZED NITROREDUCTASE FOR PRODRUG ACTIVATOR GENE THERAPY IN HUMAN GLIOMA MODELS by Collins, Sara, Inagaki, Akihito, Tai, Chien-Kuo, Logg, Christopher R, Searle, Peter, Tangney, Mark, Kasahara, Noriyuki

“…Early-phase clinical trials of Toca 511, a retroviral replicating vector (RRV) expressing an optimized form of yeast cytosine deaminase for prodrug activator…”
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IMMU-09. DISSECTING THE INTERPLAY BETWEEN THE ENDOGENOUS IMMUNE RESPONSE AND ONCOLYTIC VIRUS THERAPY IN PEDIATRIC BRAIN TUMORS by Hoare, Owen, Jung, Jangham, Inagaki, Akihito, Yu, Bohyeon, Collins, Sara, Chuntova, Polly, Barcova, Maria, Patel, Trishna, Kasahara, Noriyuki, Müller, Sabine, Diaz, Aaron

“…Oncolytic virus (OV) elicits an antitumor immune response in addition to tumor-cell killing. However, it is unknown if a pre-existing antitumor immune response…”
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Abstract B03: Development of retroviral replicating vectors expressing codon-optimized nitroreductase for prodrug activator gene therapy in human glioma models by Collins, Sara, Inagaki, Akihito, Tangney, Mark, Kasahara, Noriyuki

“…Our studies to date have demonstrated dramatic survival benefit when tumor-selective retroviral replicating vectors (RRV) are employed for gene therapy in a…”
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Abstract A43: Therapeutic efficacy of retroviral replicating vectors in orthotopic models of breast cancer metastasis to the brain by Inagaki, Akihito, Collins, Sara, Matsuura, Suzanne, Kasahara, Noriyuki

“…Our studies to date have demonstrated that retroviral replicating vectors (RRV) are capable of highly efficient replication in cancer cells in vitro and in…”
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Therapeutic activity of retroviral replicating vector-mediated gene therapy in combination with anti-PD-1 antibody in a murine pancreatic cancer model by Niwa, Hiroki, Nakamura, Toru, Kushiya, Hiroki, Kuraya, Tomotaka, Inoko, Kazuho, Inagaki, Akihito, Suzuki, Tomohiro, Sasaki, Katsunori, Tsuchikawa, Takahiro, Hiraoka, Kei, Shichinohe, Toshiaki, Hatanaka, Yutaka, Jolly, Douglas J., Kasahara, Noriyuki, Hirano, Satoshi

“…Toca 511, a tumor-selective retroviral replicating vector encoding the yeast cytosine deaminase (yCD) gene, exerts direct antitumor effects through…”
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THER-06. THERAPEUTIC EFFICACY OF RRV-MEDIATED PRODRUG ACTIVATOR GENE THERAPY IN CLINICAL TRIALS OF RECURRENT HIGH-GRADE GLIOMA AND IN MURINE ORTHOTOPIC MODELS OF INTRACEREBRAL GLIOMA AND INTRACEREBELLAR MEDULLOBLASTOMA by Richardson, Angela, Collins, Sara, Inagaki, Akihito, Armstrong, Valerie, Robbins, David, Ayad, Nagi, Gruber, Harry, Jolly, Douglas, Cloughesy, Timothy, Kasahara, Noriyuki

“…Toca 511, a clinical-stage tumor-selective retroviral replicating vector (RRV), encodes optimized yeast cytosine deaminase (CD), which converts the prodrug…”
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Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells by Kozlowska, Anna K., Tseng, Han-Ching, Kaur, Kawaljit, Topchyan, Paytsar, Inagaki, Akihito, Bui, Vickie T., Kasahara, Noriyuki, Cacalano, Nicholas, Jewett, Anahid

“…Natural killer (NK) cells are functionally suppressed in the glioblastoma multiforme (GBM) tumor microenvironment. We have recently shown that survival and…”
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EXTH-65. INSERTION OF MICRORNA TARGET SEQUENCES INTO RETROVIRAL REPLICATING VECTORS EFFECTIVELY RESTRICTS TRANSGENE EXPRESSION AND VIRAL REPLICATION IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS by Collins, Sara, Inagaki, Akihito, Barcova, Maria, Freedman, Alicia, Montoya, Megan, Haddad, Alexander, Hacke, Katrin, Matsuura, Suzanne, Timberlake, Nina, Lin, Amy, Jolly, Douglas, Kasahara, Noriyuki

“…Prodrug activator gene therapy with a retroviral replicating vector (RRV) has shown a highly favorable safety profile and long-term survival in early-phase…”
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Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression by Perez, Omar D, Logg, Christopher R, Hiraoka, Kei, Diago, Oscar, Burnett, Ryan, Inagaki, Akihito, Jolson, Dawn, Amundson, Karin, Buckley, Taylor, Lohse, Dan, Lin, Amy, Burrascano, Cindy, Ibanez, Carlos, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J

“…Retroviral replicating vectors (RRVs) are a nonlytic alternative to oncolytic replicating viruses as anticancer agents, being selective both for dividing cells…”
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Abstract A42: Alternate pseudotypes overcome receptor interference and enable combination suicide gene therapy with retroviral replicating vectors by Grosso, James, Collins, Sara, Inagaki, Akihito, Matsuura, Suzanne, Slomovitz, Brian, Ince, Tan, Kasahara, Noriyuki

“…Retroviral replicating vectors (RRVs) have been shown to achieve efficient tumor transduction and enhanced therapeutic benefit in a wide variety of cancer…”
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Retroviral Replicating Vector Toca 511 ( Vocimagene Amiretrorepvec ) for Prodrug Activator Gene Therapy of Lung Cancer by Kushiya, Hiroki, Hiraoka, Kei, Suzuki, Tomohiro, Inoko, Kazuho, Inagaki, Akihito, Niwa, Hiroki, Sasaki, Katsunori, Nakamura, Toru, Tsuchikawa, Takahiro, Shichinohe, Toshiaki, Jolly, Douglas J, Kasahara, Noriyuki, Hirano, Satoshi

“…Therapeutic efficacy of retroviral replicating vector (RRV)-mediated prodrug activator gene therapy has been demonstrated in a variety of tumor models, but…”
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STEM-24. THERAPEUTIC APPROACH OF STEM CELL CARRYING RETROVIRAL REPLICATING VECTORS IN HUMAN GLIOMA MODEL by Inagaki, Akihito, Takahashi, Masamichi, Kamijima, Shuichi, Hiraoka, Kei, Tam, Quincy, Faure-Kumar, Emmanuelle, Treger, Janet, Bogan, Brooke, Hacke, Katrin, Collins, Sara, Jolly, Douglas, Kasahara, Noriyuki

“…Abstract Toca 511, an improved retroviral replicating vectors (RRVs) expressing a codon-optimized cytosine deaminase, has shown highly promising evidence of…”
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